Exploring the Effects of Polyglutamylation of α-Tubulin C-terminal Regions Through All-Atom Molecular Dynamics DOI Open Access
Ekaterina G. Kholina, Nikita B. Gudimchuk

Mathematical Biology and Bioinformatics, Journal Year: 2024, Volume and Issue: 19(2), P. 418 - 426

Published: Dec. 4, 2024

The tubulin cytoskeleton, consisting of a network microtubules, is key intracellular system that supports the execution numerous vital cellular functions. Its operation regulated by post-translational modifications, which are introduced and edited enzymes, recognized regulatory proteins, or directly influence properties tubulins. One such modification polyglutamylation C-terminal regions tubulin. In this study, we investigated effect adding additional glutamate residues on dynamics α-tubulin their interactions with globular domains using all-atom molecular simulations. analysis simulation data totaling over three microseconds for both modified unmodified revealed decreases average distance between base tip unstructured region, increasing likelihood its contact domain protein, including polymerization interface. These findings suggest may act as factor influencing kinetics microtubule assembly.

Language: Английский

Piezoelectricity and flexoelectricity in biological cells: the role of cell structure and organelles DOI
Akepogu Venkateshwarlu,

AKSHAYVEER Akshayveer,

Sundeep Singh

et al.

Biomechanics and Modeling in Mechanobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Language: Английский

Citations

4
Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research DOI Creative Commons
Melika Mohammadkhah, Vukašin Slavković, Sandra Klinge

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(6), P. 579 - 579

Published: May 28, 2025

Flexoelectricity arises in materials under strain gradients, which can be particularly significant for situations the existence of other electromechanical properties is absent or generating large flexoelectric achievable. This effect has also been observed some biological materials, whose understanding hugely help to further enhance our vital processes like mechanotransduction, as well development applications regenerative medicine and drug delivery. While field flexoelectricity a relevant topic relatively new still developing, current study aims review available results on effects such cells cell membranes, hearing mechanisms, bone, their potential biomedical research. Therefore, we first provide brief background two main couplings (piezoelectricity flexoelectricity) further, how experimentally theoretically identified. We then different aim study. Within that, additional emphasis influence this bone remodeling. In particular, outlines limitations provides directions future work, emphasizing crucial role next-generation devices optimizing function area

Language: Английский

Citations

0
VII Congress of Russian Biophysicists—2023, Krasnodar, Russia DOI Open Access
Anastasia A. Anashkina, Andrey B. Rubin, Nikita B. Gudimchuk

et al.

Biophysical Reviews, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 13, 2023

Language: Английский

Citations

3
Tubulin Homologs in Bacteria and Archaea DOI
N. A. Rumyantseva,

D. M. Golofeeva,

A. A. Khasanova

et al.

Microbiology, Journal Year: 2024, Volume and Issue: 93(3), P. 243 - 258

Published: May 14, 2024

Language: Английский

Citations

0
Tubulin Homologs in Bacteria and Archaea DOI
N. A. Rumyantseva,

D. M. Golofeeva,

A. A. Khasanova

et al.

Микробиология, Journal Year: 2024, Volume and Issue: 93(3), P. 249 - 266

Published: Sept. 30, 2024

Language: Английский

Citations

0
Exploring the Effects of Polyglutamylation of α-Tubulin C-terminal Regions Through All-Atom Molecular Dynamics DOI Open Access
Ekaterina G. Kholina, Nikita B. Gudimchuk

Mathematical Biology and Bioinformatics, Journal Year: 2024, Volume and Issue: 19(2), P. 418 - 426

Published: Dec. 4, 2024

The tubulin cytoskeleton, consisting of a network microtubules, is key intracellular system that supports the execution numerous vital cellular functions. Its operation regulated by post-translational modifications, which are introduced and edited enzymes, recognized regulatory proteins, or directly influence properties tubulins. One such modification polyglutamylation C-terminal regions tubulin. In this study, we investigated effect adding additional glutamate residues on dynamics α-tubulin their interactions with globular domains using all-atom molecular simulations. analysis simulation data totaling over three microseconds for both modified unmodified revealed decreases average distance between base tip unstructured region, increasing likelihood its contact domain protein, including polymerization interface. These findings suggest may act as factor influencing kinetics microtubule assembly.

Language: Английский

Citations

0