Atomic force microscopy at the forefront: unveiling foodborne viruses with biophysical tools

npj Viruses, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 4, 2025

Foodborne viruses are significant public health threats, capable of causing life-threatening infections and posing major risks for future pandemics. However, the development vaccines treatments remains limited due to gaps in understanding their biophysical properties. Among these viruses, noroviruses currently leading cause viral gastroenteritis globally responsible numerous foodborne outbreaks. In this review, we explore use methods, with a focus on atomic force microscopy (AFM), study viruses. We demonstrate how AFM can provide crucial insights into virus-host interactions, transmission dynamics, environmental stability. also show that integration various approaches offers new opportunities advancing our ultimately guiding effective prevention strategies antiviral therapies.

Language: Английский

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Advances and Challenges in Antiviral Development for Respiratory Viruses

Pathogens, Journal Year: 2024, Volume and Issue: 14(1), P. 20 - 20

Published: Dec. 31, 2024

The development of antivirals for respiratory viruses has advanced markedly in response to the growing threat pathogens such as Influenzavirus (IAV), syncytial virus (RSV), and SARS-CoV-2. This article reviews advances challenges this field, highlighting therapeutic strategies that target critical stages viral replication cycle, including inhibitors entry, replication, assembly. In addition, innovative approaches inhibiting host cellular proteins reduce resistance repurposing existing drugs are explored, using bioinformatics tools optimize identification antiviral candidates. analysis also covers emerging technologies nanomedicine CRISPR gene editing, which promise improve stability efficacy treatments. While current offer valuable options, they face evolution need accessible treatments vulnerable populations. underscores importance continued innovation biotechnology overcome these limitations provide safe effective Combining traditional developing is essential order address diseases affect global health.

Language: Английский

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Antiviral Effects and Mechanisms of Active Ingredients in Tea

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5218 - 5218

Published: Nov. 4, 2024

Viruses play a significant role in human health, as they can cause wide range of diseases, from mild illnesses to severe and life-threatening conditions. Cellular animal experiments have demonstrated that the functional components tea, such catechins, theaflavins, theanine, caffeine, exhibit inhibitory effects on diverse array viruses, including influenza, rotavirus, hepatitis, HPV, additional types. The inhibition mechanisms may involve blocking virus-host recognition, interfering with viral replication, enhancing host immune responses, inhibiting enzyme activity. This article reviews research progress antiviral tea's their related mechanisms, hoping contribute future studies this field.

Language: Английский

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Pioneering use of human intestinal enteroids to prevent foodborne transmission of human norovirus

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104843 - 104843

Published: Dec. 1, 2024

Language: Английский

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