Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

The Journal of Physiological Sciences, Journal Year: 2017, Volume and Issue: 68(1), P. 19 - 31

Published: Sept. 30, 2017

A number of studies have reported that zinc plays a substantial role in the development metabolic syndrome, taking part regulation cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes scavenge reactive oxygen species, reducing oxidative stress. Zinc correct functioning lipid glucose metabolism, regulating forming expression insulin. In numerous studies, supplementation has been found improve blood pressure, glucose, LDL cholesterol serum level. Deeper knowledge zinc's properties may help treating thus protecting against stroke angina pectoris, ultimately death.

Language: Английский

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Microplastics in the environment: Interactions with microbes and chemical contaminants

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 743, P. 140518 - 140518

Published: July 1, 2020

Language: Английский

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A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models

Nutrients, Journal Year: 2020, Volume and Issue: 12(3), P. 762 - 762

Published: March 13, 2020

Zinc absorption in the small intestine is one of main mechanisms regulating systemic homeostasis this essential trace element. This review summarizes key aspects human zinc and distribution. In particular, current knowledge on intestinal influence diet-derived factors bioaccessibility bioavailability as well intrinsic luminal basolateral with an impact uptake are discussed. Their investigation increasingly performed using vitro cellular models, which continually being refined keep gaining importance for studying transport via epithelium. The vast majority these models based cell line Caco-2 combination other relevant components epithelium, such mucin-secreting goblet cells digestion applying improved compositions apical media to mimic vivo situation closely possible. Particular emphasis placed summarizing previous applications results comparing their data obtained humans, discussing advantages limitations.

Language: Английский

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Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(2), P. 476 - 476

Published: Feb. 6, 2018

Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the underlying molecular mechanisms remained unclear. The breakthrough discovery that common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into role of Our group others showed altered ZnT8 function be involved pathogenesis diabetes, indicating precise control homeostasis crucial maintaining health preventing various diseases, including lifestyle-associated diseases. Recently, ZIP13 regulation beige adipocyte biogenesis was clarified, which indicated as possible therapeutic target metabolic syndrome. Here we review advances pathophysiology propose inadequate distribution affect onset diseases by regulating critical biological events.

Language: Английский

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Zinc transporters and their functional integration in mammalian cells

Journal of Biological Chemistry, Journal Year: 2021, Volume and Issue: 296, P. 100320 - 100320

Published: Jan. 1, 2021

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc dynamics cells provide crucial cellular signaling opportunities, but also challenges for intracellular homeostasis with broad disease implications. transporters play central role regulating balance and subcellular distributions. discoveries of two complementary families mammalian (ZnTs ZIPs) the mid-1990s spurred much speculation on their selectivity functions. After decades research, we have arrived at biochemical description transport. However, vitro functions are fundamentally different from those cells, where directed to specific locations, engaged dedicated macromolecular machineries, connected diverse processes. Hence, molecular individual reshaped deeply integrated promote utilization chemistry perform enzymatic reactions, tune responsiveness pathophysiologic signals, safeguard homeostasis. At present, underlying mechanisms driving functional integration largely unknown. This knowledge gap has motivated shift research focus studies purified cell context locations protein interactions. In this review, will outline how been accumulated in-test-tube in-cell studies, highlighting new insights paradigm shifts our understanding basis transporter defining feature eukaryotic proteomes, populating zinc-binding proteins that encoded by ∼10% human genome (1Rosenzweig A.C. Metallochaperones: Bind deliver.Chem. Biol. 2002; 9: 673-677Abstract Full Text PDF PubMed Scopus (165) Google Scholar, 2Andreini C. Banci L. Bertini I. Rosato A. Counting zinc-proteins genome.J. Proteome Res. 2006; 5: 196-201Crossref (592) Scholar). While fundamental biology, it later addition proteomes after advent geochemical an ancient high-sulfide ocean modern oxidizing, sulfate-rich one (3Bekker Holland H.D. Wang P.L. Rumble 3rd, D. Stein H.J. Hannah J.L. Coetzee L.L. Beukes N.J. Dating rise atmospheric oxygen.Nature. 2004; 427: 117-120Crossref (922) 4Arnold G.L. Anbar A.D. Barling J. Lyons T.W. Molybdenum isotope evidence widespread anoxia mid-Proterozoic oceans.Science. 304: 87-90Crossref (447) release sulfide-bound provided bioavailability prompt burst innovation structures such as fingers consequences quickening diversification eukaryotes evolution (5Dupont C.L. Butcher Valas R.E. Bourne P.E. Caetano-Anolles G. History inferred through phylogenomic analysis structures.Proc. Natl. Acad. Sci. U. S. 2010; 107: 10567-10572Crossref (197) came expense increasing risk interference preexisting machineries evolved earlier. Accordingly, body harnesses potentially toxic spatially confined manner avoid cytotoxicity. organ level, highly enriched hippocampus neocortex region brain, prostate gland, islets Langerhans pancreas (6Kambe T. Matsunaga M. Takeda T.A. Understanding contribution function early secretory pathway.Int. Mol. 2017; 18 (2179)Crossref (26) These tissues accumulate abundant into pathways stored demand. total content submillimolar uneven distributions ranging picomolar range free cytosolic over 20 mM specialized vesicles (7Eide D.J. trafficking zinc.Biochim. Biophys. Acta. 1763: 711-722Crossref (582) 8Vinkenborg Nicolson T.J. Bellomo E.A. Koay M.S. Rutter G.A. Merkx Genetically FRET sensors monitor Zn2+ homeostasis.Nat. Methods. 2009; 6: 737-740Crossref (311) 9Bozym R.A. Thompson R.B. Stoddard A.K. Fierke C.A. Measuring exchangeable PC-12 using ratiometric fluorescence biosensor.ACS Chem. 1: 103-111Crossref (201) 10Dunn M.F. Zinc-ligand interactions modulate assembly stability insulin hexamer -- review.Biometals. 2005; 18: 295-303Crossref (196) 11Dodson Steiner insulin's biosynthesis.Curr. Opin. Struct. 1998; 8: 189-194Crossref (401) For example, pancreatic β-cells packaging, epithelial citrate production, mammary lactation (12Kelleher S.L. McCormick N.H. Velasquez V. Lopez tissues: Roles pancreas, prostate, gland.Adv. Nutr. 2011; 2: 101-111Crossref (187) selectively capture transport ions across membrane barriers control gradients various membranes. Mammalian belong (13Kambe Yamaguchi-Iwai Y. Sasaki R. Nagao Overview transporters.Cell Life 61: 49-68Crossref (320) Scholar): Transporter (ZnT) (14Palmiter R.D. Huang Efflux compartmentalization members SLC30 family solute carriers.Pflugers Arch. 447: 744-751Crossref (316) Scholar) Zrt, Irt-like Protein (ZIP) (15Jeong Eide SLC39 transporters.Mol. Aspects Med. 2013; 34: 612-619Crossref (236) Ten ZnT 14 ZIP homologs SLC30A1-10 SLC39A1-14 genes humans, respectively Common ability selective binding, bound ZnTs ZIPs transported opposite directions. efflux responsible removing excess cytoplasm, whereas uptake replenish (Fig. 1, A–C). stabilize concentration around homeostatic setpoint while enriching lumen compartments support zinc-dependent multisite localizations increase number protein–protein drive cross talks between array performing processes beyond organized hierarchy scales—from complexes up constitute physiology cells. review begin isolated illuminate coordination geometric arrangements binding residues confer bindings structural move or down membrane. In-cell further showcase distinct response environmental stimuli. next level integrations takes place which coordinate networks involved signaling, endoplasmic reticulum (ER) unfolded response, activation ectoenzymes pathway. involvement provides global pathophysiology. Finally, summarize existing loss-of-function (LOF) mutations polymorphisms clinical manifestations major diseases. Cells acquire variety transition elements including iron, zinc, copper, manganese, cobalt, nickel, molybdenum, tungsten, chromium, vanadium. metals may exist tightly forms metal-bound cofactors nucleic-acid-bound species, loosely association heterogeneous buffer. Biomolecules milieu extraordinary chelation capacity, probably containing high-affinity sites relative (16Finney L.A. O'Halloran T.V. Transition speciation cell: Insights ion receptors.Science. 2003; 300: 931-936Crossref (861) According Irving–Williams series divalent (17Irving H. Williams R.J.P. complexes.J. Soc. 1953; 637: 3192-3210Crossref (0) Scholar), copper would form most stable complexes, preferentially accumulating biomolecules if presented equal amounts test tube. organisms, acquired override intrinsic thermodynamic propensity selection enable metal-specific As such, essential aspect composition metallome safeguarding fidelity delivery right amount. directions mechanisms, common these overall zinc. raises question exploit select against other similar ions. unusual electron configuration [Ar]3d10. completely filled d-orbital renders redox-inert, its ionic fixed valence state +2. considered borderline soft-hard metal, being coordinated both sulfur atom cysteine nitrogen histidine (soft base ligands) carboxylate oxygen atoms aspartate glutamate (hard (18Vahrenkamp Why does nature use zinc--a personal view.Dalton Trans. 2007; : 4751-4759Crossref (106) Often, water molecules participate ligation particular conformations. some cases, molecule positively charged center reduces pKa 15.7 ∼7, generating hydroxide catalytically active species (19Baird Jr., T.T. Waheed Okuyama Sly W.S. Catalysis inhibition carbonic anhydrase IV.Biochemistry. 1997; 36: 2669-2678Crossref A d subshell marked preference tetrahedral geometry (20Laitaoja Valjakka Janis spheres structures.Inorg. 52: 10983-10991Crossref (117) dictated 18-electron rule (21Langmuir Types valence.Science. 1921; 54: 59-67Crossref (145) addition, penta- hexa-coordinated Zn(II) frequently found metalloenzymes inhibitors solvent each site broadly categorized (N) bond angles (N = 4), trigonal bipyramidal 5), octahedral geometries 6). Despite variability environments, affinity toward usually high μM pM metalloproteins (22Maret W. New perspectives environments proteins.J. Inorg. Biochem. 2012; 111: 110-116Crossref (122) 23Maret Li Coordination proteins.Chem. Rev. 109: 4682-4707Crossref (419) vectorial movements barrier. two-step process, chemical properties dictate metal-binding immediate surroundings afford selectivity. bacteria, archaea, 24Paulsen Saier M.J. novel heavy Membr. 156: 99-103Crossref 25Eide transporters.Pflugers 796-800Crossref (284) bacterial transporters, YiiP ZIPB, representative crystal determined and/or isomorphous Cd(II) 2, B). selectivities ZIPB explicitly determined, providing experimental correlating geometry. integral cytoplasmic Escherichia coli (26Grass Fan B. Rosen B.P. Franke Nies D.H. Rensing ZitB (YbgR), member cation diffusion facilitator family, additional coli.J. Bacteriol. 2001; 183: 4664-4667Crossref (119) It belongs (CDF) (27Montanini Blaudez Jeandroz Sanders Chalot Phylogenetic Cation Diffusion Facilitator family: Improved signature prediction substrate specificity.BMC Genomics. 107Crossref (226) was initially thought be ferrous iron based effects deletion trans-expression growth survival (28Grass Otto Fricke Haney C.J. Munkelt FieF (YiiP) mediates decreased accumulation relieves stress.Arch. Microbiol. 9-18Crossref (151) presence redundant systems compensatory controls could lead misinformation more rigorous determination developed direct measurements proteoliposomes mediated reconstituted proteins. spectrum substrates profiled inductively coupled plasma–mass spectrometry (ICP-MS), showing Cd(II), rejected fourth period (29Hoch E. Lin Chai Hershfinkel Fu Sekler Histidine pairing Cd2+ selectivity.Proc. 7202-7207Crossref (85) profile tube identical single-cysteine mutant native plasma (30Wei Selective membrane-embedded (FieF).J. 280: 33716-33724Abstract (70) genomic target selected large collection microbial homologs. bronchiseptica, thereby termed (31Lin Love electrodiffusion Zrt-, protein, ZIPB.J. 285: 39013-39020Abstract (66) ICP-MS transports rejects Fe(II), Cu(II), Co(II), Mn(II), Ni(II) Thus, shares YiiP. cadmium group-12 d-block fifth period, respectively. They outer configurations vary radii. appears features exploited Zn(II)/Cd(II) On hand, accommodation sizes 0.74 Å 0.97 demonstrates considerable fluidity size selection, making critical distinction size-based mechanism used channels discriminate s-block metals, potassium sodium (32Doyle D.A. Morais Cabral Pfuetzner Kuo Gulbis J.M. Cohen Chait B.T. MacKinnon structure channel: Molecular K+ conduction selectivity.Science. 69-77Crossref (5443) revealed Y-shaped dimeric architecture arranged twofold axis-oriented perpendicular plane (33Lu Structure YiiP.Science. 317: 1746-1748Crossref (268) 34Lu Structural autoregulation YiiP.Nat. 16: 1063-1067Crossref (162) 2A). cryo-EM oneidensis inward-facing conformation lipid environment (35Coudray N. Valvo Hu Lasala Kim Vink Zhou Provasi Filizola Tao Fang Penczek P.A. Ubarretxena-Belandia Stokes D.L. Inward-facing cryoelectron microscopy.Proc. 110: 2140-2145Crossref (64) 36Lopez-Redondo M.L. Coudray Zhang Z. Alexopoulos alternating access YiiP.Proc. 2018; 115: 3042-3047Crossref (25) 2C). Each protomer comprises N-terminal transmembrane domain (TMD) followed C-terminal (CTD) protrudes cytoplasm. Three were protomer. intramembranous site, known localized hydrophobic core TMD Side chains four conserved (D49, D53, H153, D157) projected antiparallel helices (TM2 TM5) classic Zn(II)/Cd(II)-binding Metal-binding isothermal titration calorimetry sub-μM 37Chao Thermodynamic YiiP.J. 279: 17173-17180Abstract (76) reaction 1.23 proton upon suggesting 1:1 Cd(II)-for-proton exchange (37Chao H153 sole proton-titratable residue under physiological pH range. act donor acceptor depending coordination. showed monomeric unit consisting eight (TMs) forming single helix bundle first TMs (TM1 TM4) approximately related last (TM5–TM8) (38Zhang Liu Fellner Sui Crystal reveal binuclear pathway.Sci. Adv. 3e1700344Crossref (51) 2B). intertwine embrace within inner four-helix stabilized peripheral fill inter-TM gaps. situated core, likely cocrystallized solved without back soaking partially replace yielding conformations occupied either trapped M1 M2, bridged (E181 E181 + E211) bidentate penta-coordinated M2 hexa-coordinated. Their primarily ligands located hexapeptides: "177HNhPEG182" "207QD/NhPEG212" (h refers residue) TM4 TM5, kinked P180 P210 properly multiple ligating residues. nested neighboring TMs, M99 TM2 E239 TM6, sphere. Of note, can closely associated 4.5-Å low-dielectric-constant show richly classical complex numbers 4 6. Carboxylate anions predominantly employed 1C). offers alternative modes monodentate bonds separate bridging residue. group rearrange coordinating gives flexibility sphere maintaining constant (39Sousa S.F. Fernandes Ramos enzymes: computational study.J. Am. 129: 1378-1385Crossref (120) accommodated virtue shared geometries, despite difference Although enzymes (40Vallee B.L. Auld D.S. coordination, function, proteins.Biochemistry. 1990; 29: 5647-5659Crossref (1452) occurs less sites. Nevertheless, plays proton-coupled pH-dependent acceptor. Cysteine another prevalent many (41Barber-Zucker Shaanan Zarivach correlation classification family.Sci. Rep. 7: 16381Crossref (39) Scholar); however, conspicuously missing ZIPB. Structure-guided discovery roles conserved, alanine substitutions quartets resulted loss activity 42Ohana Hoch Keasar Kambe Yifrach O. Identification mode operation transporter.J. 284: 17677-17686Abstract (129) functionally important. Moreover, DDHD quartet transporting HDHD only. H-to-D substitution raised barrier giving refined

Language: Английский

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Zinc and COVID-19: Basis of Current Clinical Trials

Biological Trace Element Research, Journal Year: 2020, Volume and Issue: 199(8), P. 2882 - 2892

Published: Oct. 22, 2020

Language: Английский

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Role of zinc in health and disease

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 17, 2024

Abstract This review provides a concise overview of the cellular and clinical aspects role zinc, an essential micronutrient, in human physiology discusses zinc-related pathological states. Zinc cannot be stored significant amounts, so regular dietary intake is essential. ZIP4 and/or ZnT5B transport zinc ions from duodenum into enterocyte, ZnT1 transports enterocyte circulation, (bidirectional transporter) facilitates endogenous secretion intestinal lumen. Putative promoters absorption that increase its bioavailability include amino acids released protein digestion citrate, whereas phytates, casein calcium can reduce bioavailability. In 70% bound to albumin, majority body found skeletal muscle bone. excretion via faeces (predominantly), urine, sweat, menstrual flow semen. Excessive inhibit copper iron, leading deficiency anaemia, respectively. toxicity adversely affect lipid profile immune system, treatment depends on mode acquisition. Acquired usually presents later life alongside risk factors like malabsorption syndromes, but medications diuretics angiotensin-receptor blockers also cause deficiency. Inherited condition acrodermatitis enteropathica, which occurs due mutation SLC39A4 gene (encoding ZIP4), birth. Treatment involves supplementation gluconate, sulphate or chloride. Notably, oral may decrease drugs ciprofloxacin, doxycycline risedronate.

Language: Английский

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Relative Bioavailability of Trace Minerals in Production Animal Nutrition: A Review

Animals, Journal Year: 2022, Volume and Issue: 12(15), P. 1981 - 1981

Published: Aug. 4, 2022

The importance of dietary supplementation animal feeds with trace minerals is irrefutable, various forms both organic and inorganic products commercially available. With advances in research techniques, data obtained from in-vitro in-vivo studies recent years, differences between have become more apparent. Furthermore, specific mineral types can now be identified. Adhering to PRISMA guidelines for systematic reviews, we carried out an extensive literature search on previously published detailing performance responses minerals, addition their corresponding relative bioavailability values. This review covers four the main included feed: copper, iron, manganese zinc, encompasses different Their impact environmental, economic, nutritional perspectives are discussed, along biological availability production animals. Species-specific sections cover ruminants, poultry, swine. Extensive tables values all available, including those not reviewed earlier studies, thereby providing a comprehensive industry reference guide. Additionally, examine reasons variance reported values, emphasis accounting misinterpretation.

Language: Английский

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Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

Biomolecules, Journal Year: 2023, Volume and Issue: 13(2), P. 194 - 194

Published: Jan. 18, 2023

Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via mitochondrial pathway or death receptor pathway. The process apoptosis highly regulated through membrane channels apoptogenic proteins. maintains cellular balance within human body cell cycle progression. Loss control prolongs cancer survival allows accumulation mutations that can promote angiogenesis, proliferation, disrupt differentiation, increase invasiveness during tumor apoptotic has been extensively studied as a potential drug target in treatment. However, off-target activities drugs negative implications have matter concern over years. Phytochemicals (PCs) for their efficacy various lines individually synergistically. development nanoparticles (NPs) green synthesis added new dimension to advancement plant-based nanomaterials effective This review provides detailed insight into fundamental molecular pathways programmed highlights role PCs along with existing NPs treating by targeting its (PCD) network.

Language: Английский

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Biodegradable PLA-ZnO nanocomposite biomaterials with antibacterial properties, tissue engineering viability, and enhanced biocompatibility

Smart Materials in Manufacturing, Journal Year: 2022, Volume and Issue: 1, P. 100004 - 100004

Published: June 3, 2022

Polylactic acid (PLA) is a well-known biomaterial on account of its biocompatibility and biodegradability. Zinc oxide (ZnO) nanofillers may endow PLA with advantageous antibacterial tissue regenerative properties, but also compromise the PLA. Several strategies have been developed to improve biomedical practicality such composites. The importance surface properties amplifying therapeutic safety material enables two potential strategies: (i) modification ZnO nanoparticles, (ii) engineering PLA/ZnO Moreover, controllable biodegradation allows third possible strategy: (iii) biodegradation-controlled release ZnO. first part this review introduces degradation mechanisms cytotoxicity Following this, paper highlights current research trends regarding application PLA-based nanocomposites. final section discusses use in tuning rate PLA, possibility manipulating nanoparticles composites order optimize safe usage field.

Language: Английский

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