The Analyst,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 20, 2024
This
study
reports
the
synthesis
of
a
carbon
nanofiber-supported
high-entropy
alloy
material
for
electrochemical
detection
nitrites,
exhibiting
an
excellent
linear
range
and
low
limit.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Acute
myocardial
infarction
(AMI)
is
a
leading
cause
of
death
and
disability
worldwide.
MicroRNA-133a
(miRNA-133a)
serves
as
valuable
biomarker
for
AMI,
offering
specificity
stability
an
early
diagnosis.
However,
existing
miRNA
biosensors
faced
challenges
in
detecting
low
concentrations,
ensuring
accuracy,
maintaining
immunity
to
interference.
This
study
presents
novel
1D/2D
bismuth
vanadium
oxide
(BiVO4)
copper-tetraphenylporphyrin
(Cu-TCPP)
metal-organic
framework
heterojunction,
constructed
via
simple
electrodeposition
method,
which
enabled
the
development
amplification-free
photoelectrochemical/electrochemical
(PEC-EC)
dual-mode
sensor.
The
S-type
heterojunction
formed
between
Cu-TCPP
BiVO4
significantly
improved
separation
efficiency
photogenerated
carriers.
Furthermore,
peroxidase-like
catalytic
activity
facilitated
signal
amplification
through
photonanozyme
mechanism.
Experimental
results
demonstrated
that
sensor
achieved
high
sensitivity
with
extremely
detection
limits
0.003
fM
PEC
0.02
EC,
along
excellent
selectivity,
stability,
reproducibility.
provides
efficient
platform
miRNA-133a,
highlighting
its
potential
diagnosis
monitoring
diseases
linked
biomarkers.
Chemosensors,
Journal Year:
2025,
Volume and Issue:
13(4), P. 146 - 146
Published: April 16, 2025
The
development
of
cost-effective,
rapid-response,
and
user-friendly
biosensing
platforms
has
become
paramount
importance
for
achieving
precise
biomarker
quantification
in
early
disease
detection.
Implementing
timely
diagnostic
interventions
through
accurate
analysis
not
only
significantly
improves
treatment
outcomes
but
also
enables
effective
management
strategies,
ultimately
leading
to
substantial
reductions
patient
mortality
rates.
These
clinical
imperatives
have
consequently
driven
the
innovation
portable
point-of-care
(POC)
systems.
Electrochemical
biosensors
are
attractive
diagnosis
diseases
due
their
low
cost,
simple
operation,
high
sensitivity.
This
review
examines
prevalent
material
innovations
electrode
functionalization
electrochemical
platforms,
with
specific
emphasis
on
translational
applications
early-stage
included
three
important
types:
proteins,
nucleic
acids,
small
molecule
metabolites.
Furthermore,
work
proposes
novel
research
trajectories
next-generation
biosensor
development,
advocating
synergistic
integration
artificial
intelligence-driven
analytics,
Internet
Medical
Things
(IoMT)-enabled
networks,
advanced
micro/nanofabrication
techniques.