Dietary supplements in polycystic ovary syndrome–current evidence DOI Creative Commons
Yaling Han, Ye Hou,

Qimao Han

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 27, 2024

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age, and presents a significant challenge to global population. This review provides comprehensive evidence interventions, including food dietary supplements, aimed at reversing PCOS improving fertility outcomes. Various supplements are known cause metabolic changes hormonal regulation have potential impact on increasing pregnancy rates. Although some biochemical alterations been observed, these do not directly reverse disorder. Moreover, lack sufficient does convince clinicians standardize as alternatives medical or pharmacological interventions. calls for study with taking supplements. In addition, unbiased studies combinations treatment options large cohort clinical trials, will lead evidence-based medicine.

Language: Английский

Synergistic Interactions Between Probiotics and Anticancer Drugs: Mechanisms, Benefits, and Challenges DOI
Babak Pezeshki, Hussein T. Abdulabbas, Asma M. Alturki

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

1
Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012–2023) DOI Creative Commons
Ruishan Wu, Zhensheng Mai, Xiao‐Yan Song

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Polycystic ovary syndrome (PCOS) is a common gynecological condition affecting individuals of reproductive age and linked to the gut microbiome. This study aimed identify hotspots research trends within domain microbiome in PCOS through bibliometric analysis. Utilizing techniques, we examined literature on from Web Science Core Collection spanning period 2012 2023. Analytical tools such as CiteSpace, VOSviewer, Bibliometric R packages were employed evaluate various metrics, including countries/regions, institutions, authors, co-cited authors' H-index, journals, co-references, keywords. A total 191 publications identified field PCOS, with an increase annual 2018 People's Republic China was most productive country, followed by United States America (USA), India. Shanghai Jiao Tong University, Fudan Beijing University Chinese Medicine top three institutions. Thackray VG prolific author, holding highest while Liu received number citations. The journal "Frontiers Endocrinology" published articles this domain. frequently reference authored Qi XY. analysis keyword burst detection "bile acids" (2021-2023) leading frontier keyword. Additionally, "gut dysbiosis," "phenotypes," "adolescents," "metabolomics," "metabolites," "fecal microbiota transplantation," "IL-22" have emerged primary keywords reflecting recent trends. explores how influences endocrine metabolic disorders related emphasizing its role development treatments targeting findings serve valuable resource for researchers, enabling them critical emerging areas investigation field.

Language: Английский

Citations

0
Rubia cordifolia Linn.: Isolation, Molecular Docking and BRAC1/PKD1 Gene Targeting for Polycystic Ovary Syndrome in Rats DOI
D. S. Bhatia, Diksha Sharma, Kamal Shah

et al.

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104532 - 104532

Published: April 1, 2025

Language: Английский

Citations

0
PCOS and genetics: Exploring the heterogeneous role of potential genes in ovarian dysfunction, a hallmark of PCOS – A review DOI

Vidhya Dharani,

Susmita Das Nishu,

Hariprasath Lakshmanan

et al.

Reproductive Biology, Journal Year: 2025, Volume and Issue: 25(2), P. 101017 - 101017

Published: April 12, 2025

Language: Английский

Citations

0
Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics DOI Creative Commons
Meina Yang, Hongxia Deng, Siyu Zhou

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Introduction Folliculogenesis and oligo/anovulation are common pathophysiological characteristics in polycystic ovary syndrome (PCOS) patients, it is also accompanied by gut microbiota dysbiosis. It known that physical activity has beneficial effects on improving metabolism promoting ovulation menstrual cycle disorder PCOS can modulate the gastrointestinal human beings. However, mechanism remains vague. Irisin, a novel myokine, plays positive role mediating of activity. Methods Mice were randomly divided into control group, group PCOS+irisin group. model was induced dehydroepiandrosterone (DHEA) high-fat diet (HFD). The given irisin 400μg/kg intraperitoneal injection every other day for 21 days. serum sex hormones measured radioimmunoassay. Hematoxylin Eosin (H&E) Staining immunohistochemistry (IHC) conducted ovarian tissue. feces metabolomic collected 16S rRNA gene sequencing liquid chromatography-mass spectrometry (LC–MS). Results In this study, we demonstrated supplementation alleviated reproductive endocrine disorders mice, including estrous disturbance, degeneration, hyperandrogenemia. Irisin improved follicles dysplasia disorders, while had no significant effect quality oocytes. Moreover, could mitigate decreased bacteria Odoribacter increased Eisenbergiella Dubosiella mice model. alleviate fecal metabolites: Methallenestril PS (22:5(4Z,7Z,10Z,13Z,16Z)/ LTE4). Conclusion These results suggest may status modulating androgen-induced dysbiosis metabolites. Hence, our study provided evidence be considered as promising strategy treatment PCOS.

Language: Английский

Citations

3
Polycystic Ovary Syndrome and Reproductive Health: A Comprehensive Review DOI Creative Commons
Ramadan Hussein, Salman Bin Dayel, Othman Abahussein

et al.

Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 51(12)

Published: Dec. 18, 2024

Objectives: Polycystic ovary syndrome (PCOS) is a prevalent and intricate endocrine disorder that impacts women of reproductive age. It marked by various symptoms, including menstrual irregularities, hyperandrogenism, metabolic dysfunctions, with significant implications for overall health. This review aims to provide comprehensive analysis the impact PCOS on health, highlighting underlying pathophysiology, clinical manifestations, emerging therapeutic approaches. Mechanism: The current literature was detailed, focusing hormonal imbalances associated PCOS, androgen excess, insulin resistance, dysregulation hypothalamic-pituitary-ovarian (HPO) axis. also explored genetic environmental factors contributing described characteristic ovarian morphology. Findings in Brief: findings reveal not only leading cause infertility but contributes spectrum psychological issues. Recent research highlights role inflammation, gut microbiome, novel therapies managing PCOS. Despite advances, gaps understanding long-term health remain. Conclusions: underscores need individualized holistic treatment strategies integrating mental support. Continued vital improving patient outcomes advancing management this multifaceted condition.

Language: Английский

Citations

3
The Association Between Periodontal Disease and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis DOI Creative Commons

Vincenzo Bitonti,

Tiziana Perri,

Lorenzo Cigni

et al.

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(5), P. 188 - 188

Published: April 25, 2025

Background: Periodontal disease (PD) and polycystic ovary syndrome (PCOS) are two prevalent conditions that have been independently associated with systemic inflammation hormonal dysregulation. Emerging evidence suggests a potential bidirectional relationship between these conditions, but the nature strength of this association remain unclear. Objective: This systematic review aimed to evaluate synthesize existing on periodontal syndrome, following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Methods: A comprehensive literature search was conducted in multiple databases, including PubMed, Scopus, Web Science, from 1990 2025. Studies investigating PD PCOS terms prevalence, severity, shared pathophysiological mechanisms were included. Two independent reviewers screened studies eligibility, extracted data, assessed methodological quality using validated tools. Discrepancies resolved through consensus. Meta-analysis where appropriate. Results: total nine Most reported higher prevalence severity among women compared controls. Shared mechanisms, inflammation, insulin resistance, dysregulation, frequently proposed as underlying factors. However, heterogeneity study designs, diagnostic criteria, confounding adjustments limited comparability findings. Conclusions: supports likely mediated by common inflammatory metabolic pathways. is biases. Further well-designed longitudinal needed clarify causal relationships explore clinical implications integrating health management into care.

Language: Английский

Citations

0
Decoding the Lipid-POI Connection: The Mediating Role of Inflammatory Factors DOI

Tingyu Lang,

Shaoqi Hua,

Xiaolei Liang

et al.

Chemistry and Physics of Lipids, Journal Year: 2025, Volume and Issue: unknown, P. 105495 - 105495

Published: May 1, 2025

Language: Английский

Citations

0
The impact of combined use of probiotics and metformin on metabolic parameters in patients with polycystic ovary syndrome DOI Creative Commons
Xia Li, Xuan Peng

Gynecological Endocrinology, Journal Year: 2025, Volume and Issue: 41(1)

Published: May 26, 2025

This study amed to investigate the combined use of probiotics and metformin on metabolic parameters in patients with polycystic ovary syndrome (PCOS). 138 PCOS were retrospectively included from January December 2023 divided into (n = 70) probiotics-metformin combination 68) groups based their clinical treatment regimens. After three-month intervention, group showed significantly greater improvements compared high-density lipoprotein cholesterol levels (p < 0.001), insulin adiponectin 0.033). The also exhibited more significant reductions weight 0.006), waist circumference 0.037), hip 0.044), waist-hip ratio 0.031). No differences observed between changes other parameters, hormonal profiles, inflammatory markers, or quality life assessments > 0.05). retrospective pilot suggests that addition therapy may improve HDL levels, sensitivity, anthropometric measurements, alone PCOS.

Language: Английский

Citations

0
Dietary supplements in polycystic ovary syndrome–current evidence DOI Creative Commons
Yaling Han, Ye Hou,

Qimao Han

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 27, 2024

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age, and presents a significant challenge to global population. This review provides comprehensive evidence interventions, including food dietary supplements, aimed at reversing PCOS improving fertility outcomes. Various supplements are known cause metabolic changes hormonal regulation have potential impact on increasing pregnancy rates. Although some biochemical alterations been observed, these do not directly reverse disorder. Moreover, lack sufficient does convince clinicians standardize as alternatives medical or pharmacological interventions. calls for study with taking supplements. In addition, unbiased studies combinations treatment options large cohort clinical trials, will lead evidence-based medicine.

Language: Английский

Citations

2