Therapeutic Potential of Saffron Extract in Mild Depression: A Study of Its Role on Anhedonia in Rats and Humans DOI Creative Commons
Eleonora Corridori, Sara Salviati, Maria Graziella De Montis

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

ABSTRACT Drugs generally used in major depressive disorder are considered inappropriate for the more common milder forms. The efficacy of saffron extracts has been demonstrated mild to moderate depression and preclinical models depression. However, evidence activity on reduced hedonic responsiveness motivational anhedonia is limited. Since dopamine transmission dysfunctions crucially involved seems positively modulate release, we studied potential antidepressant anti‐anhedonic effects a standardized formulation extract anhedonia‐like behaviors, patients diagnosed with unipolar or bipolar We tested rat model stress‐induced using sucrose self‐administration protocols investigated molecular underpinnings this effect focusing DARPP‐32 phosphorylation pattern response reinforcer BDNF–TrkB signaling, nucleus accumbens medial prefrontal cortex. In parallel, pilot double‐blind placebo‐controlled study whether add‐on therapy symptoms anhedonia, measured by Montgomery–Åsberg Depression Rating Scale. Repeated administration restored motivation reactivity reward‐associated cues anhedonic rats, likely modulating dopaminergic signaling. depressed patients, an 8‐week induced global improvement significant reduction anhedonia. supports pro‐motivational suggests potentially useful saffron‐based augmentation strategy albeit limitations due small sample size short trial duration.

Language: Английский

Therapeutic Potential of Saffron Extract in Mild Depression: A Study of Its Role on Anhedonia in Rats and Humans DOI Creative Commons
Eleonora Corridori, Sara Salviati, Maria Graziella De Montis

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

ABSTRACT Drugs generally used in major depressive disorder are considered inappropriate for the more common milder forms. The efficacy of saffron extracts has been demonstrated mild to moderate depression and preclinical models depression. However, evidence activity on reduced hedonic responsiveness motivational anhedonia is limited. Since dopamine transmission dysfunctions crucially involved seems positively modulate release, we studied potential antidepressant anti‐anhedonic effects a standardized formulation extract anhedonia‐like behaviors, patients diagnosed with unipolar or bipolar We tested rat model stress‐induced using sucrose self‐administration protocols investigated molecular underpinnings this effect focusing DARPP‐32 phosphorylation pattern response reinforcer BDNF–TrkB signaling, nucleus accumbens medial prefrontal cortex. In parallel, pilot double‐blind placebo‐controlled study whether add‐on therapy symptoms anhedonia, measured by Montgomery–Åsberg Depression Rating Scale. Repeated administration restored motivation reactivity reward‐associated cues anhedonic rats, likely modulating dopaminergic signaling. depressed patients, an 8‐week induced global improvement significant reduction anhedonia. supports pro‐motivational suggests potentially useful saffron‐based augmentation strategy albeit limitations due small sample size short trial duration.

Language: Английский

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