Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
16
Published: June 2, 2025
Introduction
This
study
examined
the
effects
of
probiotic
supplementation
alone
or
combined
with
aerobic
exercise
on
antioxidant
capacity
and
oxidative
stress
after
high-intensity
interval
(HIIE)
in
college
students.
Methods
Thirty
male
students
were
divided
into
three
groups:
control
(C),
(P),
(PE).
The
6-week
intervention
involved
moderate-intensity
cycling
times
a
week.
All
participants
underwent
single
session
HIIE
protocol.
tests
for
maximal
oxygen
uptake
(VO
2
max),
elimination
rate
lactic
acid
(ER),
blood
markers,
rheology
performed.
Results
A
decrease
superoxide
dismutase
(SOD)
activity
was
observed
at
baseline
P
PE
groups
(
<
0.01),
while
significantly
increased
glutathione
peroxidase
(GSH-Px)
reduced
catalase
found
group
0.05).
In
groups,
SOD
0.01)
total
(T-AOC)
level
elevated
HIIE.
T-AOC
from
0.47
±
0.03
umol
Trolox/mL
to
0.78
0.07
0.56
0.04
0.82
0.05
group.
8-OHdG
both
C
0.05),
but
remained
unchanged
intervention.
High
shear
whole
viscosity
decreased
Additionally,
notable
decline
plasma
After
intervention,
medium
high
levels
0.05)
lower
than
group,
dropped
by
28.64%
Following
significant
elevation
VO
max
only
38.14
3.11
44.5
2.94
mL/kg/min
subsequent
increase
ER
detected
Discussion
These
findings
indicate
that
combining
probiotics
enhances
more
effectively
alone.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 270 - 270
Published: Feb. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Foods,
Journal Year:
2025,
Volume and Issue:
14(9), P. 1559 - 1559
Published: April 29, 2025
Neurodegenerative
disorders
such
as
Alzheimer's
disease
(AD),
the
most
common
form
of
dementia,
represent
a
growing
global
health
crisis,
yet
current
treatment
strategies
remain
primarily
palliative.
Recent
studies
have
shown
that
neurodegeneration
through
complex
interactions
within
gut-brain
axis
largely
depends
on
gut
microbiota
and
its
metabolites.
This
review
explores
intricate
molecular
mechanisms
linking
dysbiosis
to
cognitive
decline,
emphasizing
impact
microbial
metabolites,
including
short-chain
fatty
acids
(SCFAs),
bile
acids,
tryptophan
neuroinflammation,
blood-brain
barrier
(BBB)
integrity,
amyloid-β
tau
pathology.
The
paper
highlights
major
microbiome
signatures
associated
with
disease,
detailing
their
metabolic
pathways
inflammatory
crosstalk.
Dietary
interventions
promise
in
modulating
composition,
potentially
mitigating
neurodegenerative
processes.
critically
examines
influence
dietary
patterns,
Mediterranean
Western
diets,
microbiota-mediated
neuroprotection.
Bioactive
compounds
like
prebiotics,
omega-3
polyphenols
exhibit
neuroprotective
effects
by
reducing
neuroinflammation.
Furthermore,
it
discusses
emerging
microbiome-based
therapeutic
strategies,
probiotics,
postbiotics,
fecal
transplantation
(FMT),
potential
for
slowing
progression.
Despite
these
advances,
several
knowledge
gaps
remain,
interindividual
variability
responses
need
large-scale,
longitudinal
studies.
study
proposes
an
integrative,
precision
medicine
approach,
incorporating
science
into
paradigms.
Ultimately,
cognizance
at
mechanistic
level
could
unlock
novel
avenues,
offering
non-invasive,
diet-based
strategy
managing
improving
health.
Future Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: April 14, 2025
In
recent
years,
the
study
of
probiotics
has
advanced
significantly,
driven
by
growing
interest
in
their
potential
health
benefits
and
applications
food
pharmaceutical
industries.
Probiotics
are
claimed
to
enhance
gut
health,
modulate
immune
responses,
improve
digestion,
synthesize
beneficial
compounds
for
host,
even
impact
mental
through
gut-brain
axis.
However,
traditional
vitro
methods
identifying
have
limitations,
such
as
low
reproducibility
phenotypic
screening,
limited
capacity
discover
new
strains,
restricted
evaluation
safety,
inefficiencies
fully
understanding
biological
properties
responsible
health-promoting
effects.
Advancements
genomic
analysis
technology
provided
a
cost-effective
approach
further
explore
probiotic
strains
molecular
mechanisms
driving
effects
hosts.
Here,
we
describe
comprehensive
workflow
probiogenomic
aimed
at
establishing
gold-standard
pipeline
screening
based
on
genome
sequencing.
This
encompasses
steps
from
acquiring
genomes
safety-related
features,
plasticity,
markers
whole-genome
addition,
this
outlines
respective
methodological
approaches
provides
most
database
documented
date,
comprising
243
genes
potentially
associated
with
function.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
With
growing
recognition
of
the
pivotal
role
gut
microbiota
in
human
health,
probiotics
have
gained
widespread
attention
for
their
potential
to
restore
microbial
homeostasis.
However,
a
critical
challenge
persists:
limited
colonization
efficiency
among
most
probiotic
strains
compromises
therapeutic
efficacy.
This
overview
synthesizes
ecological
principles
with
cutting-edge
microbiome
research
elucidate
dynamic
interplay
between
dietary
components
and
within
intestinal
niche.
systematically
analyzes:
(1)
stage-specific
mechanisms
spanning
introduction,
establishment,
proliferation;
(2)
nutrient-driven
modulation
composition
function;
(3)
dual
common
patterns
as
both
facilitators
disruptors
persistence.
Notably,
this
identifies
key
strategies,
including
precision
delivery
prebiotic
fibers
polyphenol-microbiota
crosstalk,
that
enhance
niche
adaptation
through
pH
optimization,
adhesion
potentiation,
competitive
exclusion
pathogens.
Furthermore,
critically
evaluates
current
limitations
research,
particularly
strain-specific
variability
methodological
constraints
simulating
host-microbe-diet
tripartite
interactions.
To
bridge
these
gaps,
proposes
an
interdisciplinary
framework
integrating
omics-driven
strain
selection,
engineered
systems,
personalized
nutrition
models.
Collectively,
work
advances
mechanistic
understanding
diet-microbiota
interactions
while
providing
actionable
insights
developing
targeted
therapies
evidence-based
interventions
optimize
ecosystem
resilience.
