Association of intrinsic capacity with functional decline and mortality in older adults: a systematic review and meta-analysis of longitudinal studies

The Lancet Healthy Longevity, Journal Year: 2024, Volume and Issue: 5(7), P. e480 - e492

Published: June 27, 2024

Language: Английский

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Intrinsic capacity and recent falls in adults 80 years and older living in the community: results from the ilSIRENTE Study

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Aug. 10, 2024

Abstract Background Falls in older adults significantly impact overall health and healthcare costs. Intrinsic capacity (IC) reflects functional reserve is an indicator of healthy aging. Aims To explore the association between IC recent falls (≤ 90 days) community-dwelling octogenarians from Aging Longevity Sirente geographic area (IlSIRENTE) study. Methods The Minimum Data Set for Home Care (MDS−HC) supplementary questionnaires tests were used to assess five domains: locomotion, cognition, vitality, psychology, sensory. Scores each domain rescaled using percent maximum possible score method averaged obtain (range 0−100). Results study included 319 participants (mean age 85.5 ± 4.8 years, 67.1% women). Mean was 80.5 14.2. optimal cut-off predicting two-year risk incident loss at least one activity daily living (ADL) determined validated a subset 240 individuals without ADL disability baseline 84.7 4.4 Participants then stratified into low (< 77.6) high (≥ categories. Those with (63.9%) younger, more often males, had lower prevalence falls, disability, multimorbidity, polypharmacy. Logistic regression models including as continuous variable revealed significant higher odds falls. This unadjusted (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.94–0.98, p < 0.001), age- sex-adjusted (OR CI fully adjusted 0.93–0.99, = 0.003). When considering categorical variable, logistic showed strong 0.31, 0.16–0.60, 0.001). remained both 0.30, 0.15–0.59, 0.001) 0.33, 0.16–0.82, 0.007). locomotion independently associated 0.98, 0.97–0.99, 0.97, 0.96–0.99, model Discussion first MDS−HC-derived instrument IC. Individuals less likely report being domain. Conclusions Lower linked increased Interventions maintain improve IC, especially domain, may reduce fall octogenarians.

Language: Английский

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Cognition Assessment with ICOPE-Monitor: Identifying Candidates for Novel Therapies

Journal of the American Medical Directors Association, Journal Year: 2025, Volume and Issue: 26(4), P. 105483 - 105483

Published: Feb. 10, 2025

Language: Английский

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Development and evaluation of a Physiotherapy-led, WHO-ICOPE-Based, Person-Centered Integrated Care Program (PTICOPE) module to enhance intrinsic capacity in older adults: Protocol for a randomized controlled trial

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318513 - e0318513

Published: March 19, 2025

Background Declining intrinsic capacity (IC), encompassing domains such as locomotion, cognitive function, vitality, vision, hearing, and psychological well-being, is prevalent among older adults, impacting independence quality of life (QoL). This study aims to develop evaluate the Physiotherapy-led Person-Centered Integrated Care for Older People (PTICOPE) based on WHO-ICOPE framework enhance IC adults in Malaysia. Methods a 12-week, multicenter, randomized controlled trial involving 70 community-dwelling aged 60–75, recruited from three Pusat Aktiviti Warga Emas (PAWE) (Activity Center Adults) Northern region Participants will be either intervention group, receiving PTICOPE module workbook guided use, or control general information, healthcare education, self-care management. The recruitment participants this has not yet commenced. Recruitment expected start after completing validation module, however, it anticipated that date February 2025 end August 2025. Primary outcomes, including locomotor, psychological, cognitive, visual, hearing functions using validated scales, collected at baseline, 4 th , 8 12 week period. Secondary outcomes QoL, activities daily living, urogenital health, oral health baseline week. normality data checked. independent t-tests, Chi-square tests, paired Repeated measures ANOVA used analysis, with significant level p < 0.05. Discussion test its efficacy population residing community. findings hold potential establish an evidence-based approach enhancing adults. Trials registration Thai Clinical (Number: TCTR20241029007).

Language: Английский

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Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: May 12, 2025

Introduction Frailty is characterized by a decline in multiple physiological systems, increasing vulnerability to stressors such as surgery and anesthesia. A intrinsic capacity common among elderly populations has been demonstrated be predictor of frailty community-dwelling seniors. However, the relationship between preoperative postoperative surgical patients remains unclear. Methods This study single-center, prospective, cohort study. The will recruit participants aged 60 years above who are scheduled undergo elective colorectal surgery. Participants classified into an exposed group (intrinsic score ≤ 8) non-exposed ≥ 9) according their assessment. primary outcome risk with impaired within one year following secondary outcomes include pain scores, sleep quality, recovery grip strength, fall risk, activities daily living, onset time moderately frailty, incidence adverse events. All assessments conducted at predetermined intervals through face-to-face interviews during hospitalization via telephone follow-up post-discharge. Discussion aims clarify older capacity. seeks enable early identification capacity, allowing for implementation targeted interventions reduce frailty.

Language: Английский

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Reference centiles for intrinsic capacity to monitor clinical health outcomes in real-world primary care cohorts

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Language: Английский

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The development of intrinsic capacity measures for longitudinal research: The Longitudinal Aging Study Amsterdam

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 197, P. 112599 - 112599

Published: Oct. 9, 2024

The World Health Organization has introduced the construct of intrinsic capacity (IC) as an important component healthy ageing and overall well-being in older adults present study aimed to develop domain-specific composite IC scores validate these by examining their longitudinal relation with functioning.

Language: Английский

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Intrinsic Capacity Impairments (ICOPE Step 1 and Step 2), Cardiometabolic Risk and Immune Resilience: An Exploratory Analysis from the Gan-Dau Healthy Longevity Plan

The Journal of Frailty & Aging, Journal Year: 2024, Volume and Issue: 13(4), P. 541 - 551

Published: Aug. 29, 2024

Intrinsic capacity (IC), defined by the World Health Organization's Integrated Care for Older People (ICOPE) framework, is crucial promoting healthy aging. Understanding associations between IC impairments and age-related biomarkers can provide insights into underlying pathophysiological mechanisms potential interventions.

Language: Английский

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The Challenge of Measuring Intrinsic Capacity

The journal of nutrition health & aging, Journal Year: 2023, Volume and Issue: 27(10), P. 806 - 807

Published: Sept. 1, 2023

Language: Английский

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