Synthesis of new pyrrolo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives of piperazin-1-yl-1,3-oxazole-4-carbonitriles, prediction and evaluation of their ADMET properties DOI Creative Commons

Nadiya М. Shevchenko,

Oleksandr O. Severin, Maryna Kachaeva

et al.

Ukrainica Bioorganica Acta, Journal Year: 2024, Volume and Issue: 19(2), P. 21 - 32

Published: Dec. 30, 2024

The discovery of nucleoside antibiotics gave impetus to the development chemistry pyrrolo[2,3-d]pyrimidines and thieno[2,3-d]pyrimidines as biologically active compounds. This work describes a universal efficient approach synthesis new pyrrolo[2,3-d]pyrimidine thieno[2,3-d]pyrimidine derivatives piperazin-1-yl-1,3-oxazole-4-carbonitriles. Their potential compounds is considered ADMET-score predicted assess their further application pharmaceutical substances

Language: Английский

Synthesis of new pyrrolo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives of piperazin-1-yl-1,3-oxazole-4-carbonitriles, prediction and evaluation of their ADMET properties DOI Creative Commons

Nadiya М. Shevchenko,

Oleksandr O. Severin, Maryna Kachaeva

et al.

Ukrainica Bioorganica Acta, Journal Year: 2024, Volume and Issue: 19(2), P. 21 - 32

Published: Dec. 30, 2024

The discovery of nucleoside antibiotics gave impetus to the development chemistry pyrrolo[2,3-d]pyrimidines and thieno[2,3-d]pyrimidines as biologically active compounds. This work describes a universal efficient approach synthesis new pyrrolo[2,3-d]pyrimidine thieno[2,3-d]pyrimidine derivatives piperazin-1-yl-1,3-oxazole-4-carbonitriles. Their potential compounds is considered ADMET-score predicted assess their further application pharmaceutical substances

Language: Английский

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