Bioactive and degradable collagen-based three-dimensional scaffold encapsulated with adipose mesenchymal stem cells-derived exosomes improved diabetic wound healing

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 28, P. 606 - 618

Published: Feb. 20, 2025

Language: Английский

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Exosomes derived from human adipose mesenchymal stem cells loaded bioengineered three-dimensional amniotic membrane-scaffold-accelerated diabetic wound healing

Archives of Dermatological Research, Journal Year: 2023, Volume and Issue: 315(10), P. 2853 - 2870

Published: Aug. 30, 2023

Language: Английский

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Nanopore/Nanocavity-Based Structures as Surface-Enhanced Raman Spectroscopy (SERS) Platforms

Plasmonics, Journal Year: 2024, Volume and Issue: unknown

Published: June 12, 2024

Language: Английский

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Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury

Regenerative Therapy, Journal Year: 2023, Volume and Issue: 24, P. 407 - 416

Published: Sept. 13, 2023

Spinal cord ischemia-reperfusion injury (IR) is a terrible non-traumatic that occurs after abdominal aortic occlusion and causes serious damage to neurological function. Several treatment strategies have been suggested for IR, but they were not unable effectively improve these conditions. Herein we investigated whether exosomes derived from human placental mesenchymal stem cells (hpMSCs-Exos) in combination with hyperbaric oxygen (HBO) could alleviate promote recovery IR rats. Eighty male Sprague-Dawley rats randomly allocated into five equal groups. In addition the control group only underwent laparotomy, animals planned four groups as follows: group; IR-Exos IR-HBO + HBO group. Neurological function evaluated before, 6 h, 12 24 48 h injury. After last evaluation, tissue samples obtained stereological, biochemical, molecular assessments. Our results indicated scores (MDI), numerical density of neurons, levels antioxidative factors (GSH, SOD, CAT), anti-inflammatory cytokine (IL-10) considerably greater than group, changes more obvious ones. This while glial cells, an oxidative factor (MDA) inflammatory cytokines (IL-1β, TNF-α, IL-18), well expression apoptotic protein (caspase-3) meaningfully decreased groups, especially compared Generally, it was found co-administration hpMSCs-Exos has synergistic neuroprotective effects undergoing IR.

Language: Английский

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Human amniotic membrane hydrogel loaded with exosomes derived from human placental mesenchymal stem cells accelerate diabetic wound healing

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102590 - 102590

Published: Oct. 21, 2024

Language: Английский

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Suppression of glomerular damage, inflammation, apoptosis, and oxidative stress of acute kidney injury induced by cyclophosphamide toxicity using resveratrol in rat models

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102548 - 102548

Published: Aug. 30, 2024

Language: Английский

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Resveratrol attenuates cyclophosphamide-induced hepatic apoptosis in association with the inhibition of oxidative stress and inflammation in a rat model of acute liver injury

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102728 - 102728

Published: Jan. 7, 2025

Language: Английский

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Stem Cell-Derived Extracellular Vesicle-Mediated Therapeutic Signaling in Spinal Cord Injury

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 723 - 723

Published: Jan. 16, 2025

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising therapeutic strategy for spinal cord injury (SCI). These nanosized possess unique properties such low immunogenicity and the ability to cross biological barriers, making them ideal carriers delivering bioactive molecules injured tissues. MSC-EVs been demonstrated exert multiple beneficial effects in SCI, including reducing inflammation, promoting neuroprotection, enhancing axonal regeneration. Recent studies delved into molecular mechanisms underlying MSC-EV-mediated effects. Exosomal microRNAs (miRNAs) identified key regulators of various cellular processes involved SCI pathogenesis repair. miRNAs can influence oxidative stress, apoptosis by modulating gene expression. This review summarized current state MSC-EV-based therapies highlighting potential clinical applications. We discussed challenges limitations translating these practice, inconsistent EV production, complex cargo composition, need targeted delivery strategies. Future research should focus on optimizing production characterization, identifying miRNAs, developing innovative systems maximize SCI.

Language: Английский

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Stem cell-derived exosome treatment for acute spinal cord injury: a systematic review and meta-analysis based on preclinical evidence

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Background The study aims were to systematically review and analyze preclinical research on the efficacy of exosomes derived from various mesenchymal stem cell sources (MSC-exos) for treatment spinal cord contusion injury (SCI) in small animal models. Methods We conducted a systematic search PubMed, Embase Google Scholar databases their inception through February 29, 2024, identify eligible English-language studies based predefined inclusion exclusion criteria. Two independent investigators performed literature screening, data extraction bias assessment. Results A total 235 rats used assess locomotor recovery at initial assessment, exhibited significant improvement hind limb movement those treated with exosomes, as indicated by statistically increase Basso-Beattie-Bresnahan (BBB) scores (MD: 1.26, 95% CI: 1.14–1.38, p < 0.01) compared controls. This trend persisted final assessment across 21 studies, pooled analysis confirming similar results 1.56, 1.43–1.68, 0.01). Funnel plot asymmetry BBB both baseline endpoint assessments, suggesting potential publication bias. Exosomes bone marrow, adipose tissue, umbilical or human placental MSCs. Meta-analysis showed no differences therapeutic among these MSC-exos time points. Conclusion demonstrated considerable promise improving motor function SCI-affected rats, marrow MSC-derived having particularly notable effectiveness.

Language: Английский

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Harnessing stem cell-derived exosomes: a promising cell-free approach for spinal cord injury

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 17, 2025

Abstract Spinal cord injury (SCI) is a severe to the central nervous system that often results in permanent neurological dysfunction. Current treatments have limited efficacy and face challenges restoring function after injury. Recently, stem cell-derived exosomes gained attention as an experimental treatment for SCI due their unique properties, including superior biocompatibility, minimal immunogenicity non-tumorigenicity. With potential cell-free therapy, promote repair by enhancing nerve regeneration, reducing inflammation stabilizing blood-spinal barrier. This review summarizes advances exosome research over past years, focusing on mechanisms future prospects. Despite promising therapeutic potential, clinical translation remains challenging standardization of isolation protocols, compositional consistency long-term safety profiles require further investigation.

Language: Английский

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