Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(24), P. 2030 - 2030
Published: Dec. 17, 2024
This
study
addresses
issues
in
developing
spatially
controlled
magnetic
fields
for
particle
guidance,
synthesizing
biocompatible
and
chemically
stable
MNPs
enhancing
their
specificity
to
pathological
cells
through
chemical
modifications,
personalized
adjustments,
highlighting
the
potential
of
tumor-on-a-chip
systems,
which
can
simulate
tissue
environments
assess
drug
efficacy
dosage
a
setting.
The
research
focused
on
two
MNP
types,
uncoated
magnetite
nanoparticles
(mMNPs)
carboxymethyl
dextran
coated
superparamagnetic
(CD-SPIONs),
evaluated
transport
properties
microfluidic
systems
porous
media.
original
mMNPs
bimodal
size
distribution
narrow
fractions
(23
nm
106
by
radii)
were
demonstrated
agglomerate
magnetically
driven
flow,
forming
stationary
web
consisting
fibers
within
30
min.
CD-SPIONs
migrate
agar
gel
with
mean
pore
equal
or
slightly
higher
than
size.
migration
velocity
was
inversely
proportional
particles.
No
compression
observed
under
field
gradient
40
T/m.
In
brain
tissue,
particles
sizes
220,
350,
820
not
penetrating
while
observed.
95
penetrated
at
edge
sample,
no
For
all
particles,
movement
capillary
vessels
Particle & Particle Systems Characterization,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
Abstract
The
synthesis
of
magnetite
nanoparticles
(Fe₃O₄
NPs)
has
gained
significant
interest
due
to
their
broad
applications,
particularly
in
biomedicine
and
environmental
purification.
In
this
study,
Fe₃O₄
NPs
are
synthesized
using
a
novel
chemical
co‐precipitation
method,
yielding
with
excellent
characteristics
such
as
saturation
magnetization
41.42
emu
g
−1
,
coercivity
less
than
4
Oe,
remanence
below
0.4
demonstrating
superparamagnetic‐like
properties.
particles
achieved
an
average
size
11
nm
displayed
robust
colloidal
stability
aqueous
suspension
for
≈30
days.
Additionally,
chitosan‐coated
(Fe₃O₄‐CS)
prepared,
which
maintained
similar
magnetic
properties
slightly
lower
38.35
the
nonmagnetic
CS
layer.
To
assess
biomedical
applicability
these
NPs,
effects
on
model
proteins
human
serum
albumin
lysozyme
examined.
Circular
dichroism
studies
revealed
only
slight
decreases
α‐helix
content
indicating
minimal
alterations
secondary
structure.
Moreover,
fluorescence
indicated
local
changes
protein
tertiary
structures
without
disruption.
This
research
highlights
potential
Fe₃O₄‐CS
applications
drug
delivery
controlled
release
systems
stability,
biocompatibility,
unique
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(33), P. 17239 - 17269
Published: Aug. 12, 2024
Nanotechnology
has
opened
new
doors
of
exploration,
particularly
in
materials
science
and
healthcare.
Magnetic
nanoparticles
(MNP),
the
tiny
magnets,
because
their
various
properties,
have
potential
to
bring
about
radical
changes
field
medicine.
The
distinctive
surface
chemistry,
nontoxicity,
biocompatibility,
and,
particular,
inducible
magnetic
moment
attracted
a
great
deal
interest
morphological
structures
from
variety
scientific
domains.
This
review
presents
concise
overview
MNPs
crucial
properties
synthesis
routes.
It
also
aims
highlight
continuous
methods
available
for
MNP
production.
In
recent
years,
use
computational
understanding
behavior
been
on
rise.
Thus,
we
discuss
numerical
models
developed
understand
how
can
be
used
hyperthermia
targeting
Circle
Wilis.
With
increasing
biomedical
applications,
it
becomes
necessary
mechanisms
toxicity,
which
are
elucidated
this
review.
focuses
applications
drug
delivery,
theranostics,
MRI
contrasting
agents.
We
anticipate
that
article
will
broaden
perspective
help
functionality
applicability
better.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 645 - 645
Published: May 10, 2024
In
recent
years,
nanotechnology
has
achieved
a
remarkable
status
in
shaping
the
future
of
biological
applications,
especially
combating
fungal
diseases.
Owing
to
excellence
nanotechnology,
iron
nanoparticles
(Fe
NPs)
have
gained
enormous
attention
years.
this
review,
we
provided
comprehensive
overview
Fe
NPs
covering
key
synthesis
approaches
and
underlying
working
principles,
factors
that
influence
their
properties,
essential
characterization
techniques,
optimization
antifungal
potential.
addition,
diverse
kinds
NP
delivery
platforms
command
highly
effective
release,
with
fewer
toxic
effects
on
patients,
are
great
significance
medical
field.
The
issues
biocompatibility,
toxicity
profiles,
applications
optimized
field
biomedicine
also
been
described
because
these
most
significant
determining
inclusion
clinical
use.
Besides
this,
difficulties
regulations
exist
transition
from
laboratory
experimental
studies
(toxicity,
specific
standards,
safety
concerns)
NPs-based
agents
summarized.
Magnetochemistry,
Journal Year:
2025,
Volume and Issue:
11(2), P. 9 - 9
Published: Jan. 26, 2025
The
synthesis
of
magnetic
nanoparticles
(MNPs)
via
the
chemical,
biological,
and
physical
routes
has
been
reported
on
along
with
advantages
attendant
limitations.
This
study
focuses
sensing
emerging
theragnostic
applications
this
category
(NPs)
in
clinical
sciences
by
unveiling
unique
performance
these
NPs
biological
bacteria
nucleotide
sequencing.
Also,
terms
medicine
science,
review
analyzes
drug
delivery,
bone
tissue
engineering,
deep
brain
stimulation,
therapeutic
hyperthermia,
tumor
detection,
imaging
cell
tracking,
lymph
node
visualization,
blood
purification,
COVID-19
detection.
presents
succinct
surface
functionalization
coating
techniques
to
confer
less
toxicity
biocompatibility
during
synthesis,
which
are
often
identified
as
limitations
medical
applications.
also
indicates
that
improvement
useful
for
refining
selective
activity
MNPs
their
use
sensors
biomarkers.
In
addition,
unveils
limitations,
especially
toxicological
impacts
biomolecules,
suggests
future
research
should
pay
attention
mitigation
biotoxicity
MNPs.
Thus,
a
proficient
approach
high-performance
fit
detection
microorganisms,
better
diagnosis,
treatment
medicine.
