Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II – applications and preclinical advancements DOI
Faezeh Fathi, Tatiane de Oliveira Xavier Machado,

Helena A. C. Kodel

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, antiviral properties, particularly in vitro or silico; however, their vivo applications are hindered by inadequate absorption distribution the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) nanostructured carriers (NLC) has significant advancements represents a viable approach to improve bioavailability through different administration routes.

Language: Английский

Synthesis and Characterization of Albumin Nanoparticles Loaded by Ellagic Acid and Chitosan and Investigation of Its Anticancer Activity Against Liver Cancer Cells DOI

Anežka Hashim,

Mohadese Alirezaei, Mozhgan Soltani

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 25, 2025

Language: Английский

Citations

1
Leveraging nanostructured lipid carriers to enhance targeted delivery and efficacy in breast cancer therapy: a comprehensive review DOI

Nazish Naseem,

Poonam Kushwaha,

Faheem Haider

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 449 - 468

Published: Aug. 28, 2024

Language: Английский

Citations

4
Eco-friendly biosynthesis of silver nanoparticles using marine-derived Fusarium exquisite: optimization, characterization, and evaluation of antimicrobial, antioxidant, and cytotoxic activities DOI Creative Commons
Sally A. Ali, Mohamed Osman, Eslam Mohamed

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(5)

Published: May 1, 2025

Abstract Fungi serve as efficient biocatalysts for the eco-friendly synthesis of metal nanoparticles, yielding stable and bioactive nanomaterials. In this study, silver nanoparticles were synthesized (AgNPs) using marine-derived fungus Fusarium equiseti characterized them with various analytical methods. UV–Vis spectroscopy detected a surface plasmon resonance peak at 420 nm, confirming AgNP formation, while X-ray diffraction (XRD) verified their crystalline structure. Scanning electron microscopy (SEM) transmission (TEM) revealed spherical averaging 50 nm. FTIR analysis confirmed that fungal metabolites cap stabilize AgNPs. We optimized extracellular biosynthesis 30°C, pH 8, 2 mM AgNO₃ over 72 h. The marine-adapted F. was selected its robust metabolic capacity enzyme secretion, enhancing nanoparticle stability bioactivity. Biological assessments showed these AgNPs outperformed in antimicrobial activity, minimum inhibitory concentrations (MICs) 6.5 µg/mL against Staphylococcus aureus 7.5 Escherichia coli , plus antifungal effects on Candida albicans solani . They also displayed strong antioxidant activity (IC₅₀ = 56.98 µg/mL) cytotoxicity MCF-7 breast cancer cells 24.38 µg/mL). These enhanced likely stem from acting natural capping agents, minimizing aggregation boosting bioavailability biological interactions. Molecular docking studies reinforced results, revealing binding to microbial cell wall proteins, human apoptotic regulator Bcl-2 (an anticancer target), peroxiredoxin-5 (PRDX5). This green method provides sustainable, non-toxic alternative conventional chemical approaches, avoiding hazardous reagents delivering stable, multifunctional Future vivo validation biocompatibility are planned explore clinical pharmaceutical potential -derived Graphical

Language: Английский

Citations

0
Multivariate Optimization of Carbamazepine-Loaded Nanostructured Lipid Carriers for Brain Targeting and Epilepsy Management DOI
Priya Patel,

Rachana Vaidya,

Yashwini Kansara

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 28, 2024

Language: Английский

Citations

2
The effect of ginger extract on expression of Gli1 and Patched-1 genes involved in breast cancer signaling pathway under in vitro condition DOI Creative Commons

Seyedeh Mahsa Torabi,

Mahdi Rahaie, Asa Ebrahimi

et al.

Biomedicine, Journal Year: 2024, Volume and Issue: 44(1), P. 107 - 113

Published: March 25, 2024

Introduction and Aim: Breast cancer ranks among the leading causes of death in women worldwide. Ginger has shown potential efficacy against certain types, surpassing conventional therapies such as chemotherapy radiation. However, its molecular mechanisms remain less understood. Materials Methods: In this study, MCF-7 cells were cultured treated with various concentrations aqueous ginger extract (20, 30, 45, 65 microgram/mL) for 12, 48, 72 hours. The effects assessed through gene expression analysis cell vitality assays (MTT). Results: test revealed a direct correlation between cytotoxicity concentration. Concentrations exceeding 30 microgram/mL exhibited significant (IC50 104.03 microgram/mL). Gene demonstrated an increase Patched-1 decrease Gli1 rising concentrations. maximum occurred at after (oncogene) (tumor suppressor) are pivotal genes hedgehog (Hh) signalling pathway associated breast cancer. Conclusion: It appears that compounds play substantial role regulating progression by influencing key components pathway.

Language: Английский

Citations

1
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II – applications and preclinical advancements DOI
Faezeh Fathi, Tatiane de Oliveira Xavier Machado,

Helena A. C. Kodel

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, antiviral properties, particularly in vitro or silico; however, their vivo applications are hindered by inadequate absorption distribution the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) nanostructured carriers (NLC) has significant advancements represents a viable approach to improve bioavailability through different administration routes.

Language: Английский

Citations

1