Recent Progress in Multifunctional Stimuli-Responsive Combinational Drug Delivery Systems for the Treatment of Biofilm-Forming Bacterial Infections

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 976 - 976

Published: July 24, 2024

Drug-resistant infectious diseases pose a substantial challenge and threat to medical regimens. While adaptive laboratory evolution provides foresight for encountering such situations, it has inherent limitations. Novel drug delivery systems (DDSs) have garnered attention overcoming these hurdles. Multi-stimuli responsive DDSs are particularly effective due their reduced background leakage targeted specific host sites pathogen elimination. Bacterial infections create an acidic state in the microenvironment (pH: 5.0-5.5), which differs from normal physiological conditions 7.4). Infected areas characterized by overexpression of hyaluronidase, gelatinase, phospholipase, other virulence factors. Consequently, several stimuli-responsive been developed target bacterial pathogens. Additionally, biofilms, structured communities bacteria encased self-produced polymeric matrix, significant conferring resistance conventional antimicrobial treatments. Recent advancements nano-drug (nDDSs) show promise enhancing efficacy improving absorption targeting within biofilm matrix. nDDSs can deliver antimicrobials directly biofilm, facilitating more eradication resilient communities. Herein, this review examines challenges DDS development, focusing on antibacterial activity eradicating biofilms without adverse effects. Furthermore, advances immune system modulation photothermal therapy discussed as future directions treatment diseases.

Language: Английский

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Targeting Spore-Forming Bacteria: A Review on the Antimicrobial Potential of Selenium Nanoparticles

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4026 - 4026

Published: Dec. 12, 2024

Spore-forming bacterial species pose a serious threat to food plants and healthcare facilities that use high-temperature processing sterilizing techniques sanitize medical equipment items. These severe conditions trigger sporulation, which is the process by spore-forming bacteria, such as those of Bacillus Clostridium species, begin produce spores, are extremely resilient entities capable withstanding adverse environmental circumstances. Additionally, these spores resistant wide range disinfectants antibacterial therapies, hydrolytic enzymes, radiation, chemicals, antibiotics. Because their ability combat bacteria through several biological pathways, selenium nanoparticles (SeNPs) have emerged an effective method for either eliminating or preventing formation bacteria. This review aims investigate every potential pathway entry mechanism SeNPs impact spores. SeNPs' efficacy against infections reviewed. To precisely explain various factors can affect effectiveness, more research necessary.

Language: Английский

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Phytofabrication of Selenium-Silver Bimetallic Nanoparticles Using Echinacea purpurea Extract: Characterization and Antioxidant Activity

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, Journal Year: 2024, Volume and Issue: 15(2), P. 198 - 208

Published: Aug. 23, 2024

The phytofabrication of selenium-silver bimetallic nanoparticles (Se-Ag BNPs) utilizing Echinacea purpurea aqueous extract is investigated in this study. synthesis process characterized by a visible color change to dark reddish brown, sign indicating successful nanoparticle formation. UV-visible spectrum analysis confirms the presence SeNPs and AgNPs with absorption maxima at 268 nm 325 nm, respectively. X-ray diffraction (XRD) patterns reveal crystalline structure synthesized Se-Ag BNPs, exhibiting characteristic peaks consistent metallic silver selenium nanoparticles. Transmission electron microscopy (TEM) showcases diverse morphological structures predominantly spherical but also featuring hexagonal oval shapes. average particle size determined be 33.38 uniformity stability. Furthermore, antioxidant properties BNPs are evaluated through DPPH ABTS radical scavenging assays, demonstrating dose-dependent capabilities IC50 values 264.78 µg/mL 344.19 µg/mL, These findings underscore potential as effective antioxidants, offering promising applications various fields such biomedicine environmental remediation. Comparisons previous studies highlight efficacy biosynthesis method using producing superior activity.

Language: Английский

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