Innovative Nano Delivery Systems for Astaxanthin: Enhancing Stability, Bioavailability, and Targeted Therapeutic Applications

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(6), P. 3286 - 3304

Published: Jan. 31, 2025

Astaxanthin (AST), as a natural antioxidant, has broad application prospects in medicine and health products. However, its highly unsaturated structure significant lipophilic characteristics limit dispersibility bioavailability, thereby restricting food, medicines, nutraceuticals. To overcome these limitations, researchers have proposed the use of nano delivery systems. This review summarizes various nanocarriers, including liposomes, nanostructured lipid carriers, nanoparticles, others, analyzes their advantages enhancing solubility, stability, bioavailability AST. Furthermore, study focuses on targeted systems achieved through biomolecular modifications, which enable precise AST to specific cells or tissues, therapeutic effects. Additionally, smart-responsive systems, such pH-responsive light-sensitive are also discussed, showing immense potential release therapy. These findings provide new perspectives for nutrition clinical applications Future research should further optimize design nanocarriers broader applications.

Language: Английский

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Terpene-based novel invasomes: pioneering cancer treatment strategies in traditional medicine

Journal of Complementary and Integrative Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: July 11, 2024

Abstract Health care workers have faced a significant challenge because of the rise in cancer incidence around world during past 10 years. Among various forms malignancy skin is most common, so there need for creation an efficient and safe treatment that may offer targeted site-specific tumor penetration, reduce unintended systemic toxicity. Nanocarriers thus been employed to get issues with traditional anti-cancer drug delivery methods. Invasomes are lipid-based nanovesicles having small amounts terpenes ethanol or mixture penetrate more effectively. Compared other lipid nanocarriers, invasomes at substantially faster rate. possess number advantages, including improved effectiveness, higher compliance, patient convenience, advanced design, multifunctionality, enhanced targeting capabilities, non-invasive methods, potential combination therapies, ability overcome biological barriers,. These attributes position as promising innovative platform future treatment. The current review provides insights into invasomes, fresh organizational scheme incorporates recent research, their composition, historical development methods preparation, penetration mechanism involving effect formulation variables analysis anticancer application invasomes.

Language: Английский

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Fe3+-DOX-Mediated Self-Assembled Nanolipids for Tumor Microenvironment Activated Synergistic Ferroptotic-Chemo Therapy Assisted with MR-imaging

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 415, P. 136039 - 136039

Published: May 26, 2024

Language: Английский

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Idarubicin-loaded chitosan nanobubbles to improve survival and decrease drug side effects in hepatocellular carcinoma

Nanomedicine, Journal Year: 2025, Volume and Issue: 20(3), P. 255 - 270

Published: Jan. 15, 2025

Drug delivery strategies using chitosan nanobubbles (CS-NBs) could be used to reduce drug side effects and improve outcomes in hepatocellular carcinoma (HCC) treatment. To enhance their action, a targeting agent, such as the humanized anti-GPC3 antibody GC33 (condrituzumab), attached surface. Here, we investigated use of idarubicin-loaded CS-NBs for HCC treatment GC33-derived minibody (that named 4A1) CS-NB delivery. Various formulations were prepared with or without 4A1 conjugation idarubicin loading. had positive charge diameter about 360 nm. In in-vitro experiments HCC-like HUH7 cell line, showed cytotoxic effect once loaded idarubicin. In-vivo biodistribution tumor-bearing xenograft mice demonstrated that can accumulate tumor mass. This was enhanced by (p = 0.0317). mice, conjugated not both able slow growth, increase mouse survival time compared free 0.00044 0.0018, respectively) well effects. useful strategy

Language: Английский

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Surface-functionalized pullulan-based polymeric nanoparticles containing resveratrol: a green approach for lung cancer targeted delivery

Particulate Science And Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 13, 2025

Pullulan, a natural polysaccharide with unique biocompatibility and biodegradability, has gained prominence in nanomedicine. The demand for the development of environmentally sustainable, low-cost, controlled-release drug delivery systems cancer treatment is emerging. Resveratrol compound that anticancer properties. Targeted direct therapeutic agents specifically to cells or tumor microenvironment, minimizing off-target effects improving efficacy. polymeric nanoparticles specific properties functionalities, researchers can achieve precise, efficient, controlled delivery, make them versatile tool site-specific therapy various diseases. This study focuses on developing accessing surface-functionalized designed targeted an agent, resveratrol. comprise pullulan polymer are ligand n-acetyl glucosamine enhance targeting specificity. Various parameters including particle size, zeta potential, differential scanning calorimetry (DSC), FTIR, field emission electron microscopy (FESEM), transmission (TEM), x-ray diffraction (XRD), entrapment efficiency (EE), loading analyzed characterize comprehensively. In vitro evaluation conducted using A549 cell line, cellular uptake, apoptosis, cytotoxicity evaluated via MTT assay determine efficacy delivering resveratrol cells. Additionally, vivo utilizing rat model pulmonary route performed evaluate pharmacokinetics biodistribution nanoparticles. this lie their ability combine biocompatibility, release, multifunctional applications, making promising platform Overall, research provides sustainable offering potential advancements therapy.

Language: Английский

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pH-responsive drug-targeted delivery system: Dual-drug loading hollow mesoporous silica for synergistic therapy bacterial enteritis of Micropterus salmoides

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163819 - 163819

Published: May 1, 2025

Language: Английский

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Green Synthesis and Anti‐Inflammatory Activity of Silver Nanoparticles Based on Leaves Extract of Aphania senegalensis

Biochemistry Research International, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

This study focuses on the synthesis of silver nanoparticles (AgNPs) using extract Aphania senegalensis leaves. The extraction was done maceration at room temperature in water for 48 h. synthesized were characterized by IR, XRD, TEM, and SEM. thermal stability these studied TGA. zeta potential used to define size, charge distribution, nanoparticles. Optimization reactions carried out based reaction time, pH, temperature. obtained from optimal conditions evaluated induced inflammation. determination average diameters geometry XRD calculating lattice constants, they are between 18.11 50 nm. evaluation anti‐inflammatory activity showed that 10 times more active than Minimum doses mg/kg orally 3 plant extract, respectively. These results promising possibility AgNPs be treatment

Language: Английский

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Electrospun lignin-loaded artificial periosteum for bone regeneration and elimination of bacteria

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137149 - 137149

Published: Nov. 5, 2024

Language: Английский

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