Synergistic combinatorial delivery system based on nanoliposome encapsulating doxorubicin and sorafenib for broad-spectrum cancer treatment DOI
Farwa Nurjis, Usama Sarwar, Joham Sarfraz Ali

et al.

Journal of Microencapsulation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 24, 2025

A novel combination delivery approach entrapping Sorafenib inside a nanoliposome bilayer and Doxorubicin within the aqueous core to achieve broad-spectrum synergistic chemotherapeutic effect. DOX-SOR liposomes were synthesized by thin film hydration characterized using UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy, Dynamic Light Scattering, Fluorescence, Scanning Electron Microscopy, followed cytotoxicity assessments. Nanoliposomes demonstrated effective loading encapsulation of (10.23% ± 0.65 89.65% 0.52) (10.42% 0.50 85.35% 0.72) with 165 nm 1.34 mean diameter, -15.2 1.78 zeta potential, 75% 1.92 cumulative release. In vitro analysis nanoliposomes biocompatibility up 250 µg/mL concentration (p < 0.05), enhanced intracellular localization in Hep2c cell lines, 91% 1.72 cytotoxic effects 0.0001) IC50 127µg/mL, 21% 0.89 viability 85% apoptosis flow cytometer. This study presents promising treatment multidrug-loaded for chemotherapy.

Language: Английский

Synergistic combinatorial delivery system based on nanoliposome encapsulating doxorubicin and sorafenib for broad-spectrum cancer treatment DOI
Farwa Nurjis, Usama Sarwar, Joham Sarfraz Ali

et al.

Journal of Microencapsulation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 24, 2025

A novel combination delivery approach entrapping Sorafenib inside a nanoliposome bilayer and Doxorubicin within the aqueous core to achieve broad-spectrum synergistic chemotherapeutic effect. DOX-SOR liposomes were synthesized by thin film hydration characterized using UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy, Dynamic Light Scattering, Fluorescence, Scanning Electron Microscopy, followed cytotoxicity assessments. Nanoliposomes demonstrated effective loading encapsulation of (10.23% ± 0.65 89.65% 0.52) (10.42% 0.50 85.35% 0.72) with 165 nm 1.34 mean diameter, -15.2 1.78 zeta potential, 75% 1.92 cumulative release. In vitro analysis nanoliposomes biocompatibility up 250 µg/mL concentration (p < 0.05), enhanced intracellular localization in Hep2c cell lines, 91% 1.72 cytotoxic effects 0.0001) IC50 127µg/mL, 21% 0.89 viability 85% apoptosis flow cytometer. This study presents promising treatment multidrug-loaded for chemotherapy.

Language: Английский

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