Evaluating the Wound Healing Potential of Characterized Bergenia ciliata–Loaded Salvia hispanica Hydrogel in Diabetic Mice

Microscopy Research and Technique, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

ABSTRACT The current study assessed the wound healing potential of Bergenia ciliata (BC) extract, BC‐loaded Salvia hispanica hydrogel (CH‐BC) and nanoparticles (NPs)–loaded (CH‐BC AgNPs/NPs‐loaded hydrogel) using in vitro vivo studies. prepared its components were analyzed UV–visible spectrophotometry (UV–vis), scanning electron microscopy (SEM), dynamic light scattering (DLS) analysis/particle size analyzer (PSA), zeta potential, fourier transform infrared spectrometry (FT‐IR), x‐ray diffraction (XRD). Peaks peak shifts at 450–460, 250–260, 270–280 nm UV–vis FT‐IR (500–4000 cm −1 ) confirmed extract loading various functional group presence. DLS nanometric BC AgNP while indicated slightly negative charge hydrogel. SEM average topography –mediated (BC AgNPs) AgNPs loaded AgNPs), XRD peaks 2ϴ (10–70) topographical crystalline porous nature materials. showed higher radical scavenging (74.19% ± 1.84%) iron chelation activity (93.70 2.20) 50 25 μL/mL, respectively, CH‐BC produced lowest (48.97% 3.0%) 75 μL/mL (54.35 3.24). Moreover, Chia (CH) synergistically enhanced (1.30%) DPPH scavenging. contraction percentage augmented as potent candidate for (14th day). These findings further supported by a significant ( p < 0.001) restoration MMP2 (184.6 11.7 pg/mL), TIMPs (184.8 15.7 GPx (153.4 11.5 IL‐6 (10 1 pg/mL) levels compared to those diabetic control. normal reepithelization, angiogenesis, maturation wounds treatment groups after histological analysis strengthened supposed rationale that CH, along with AgNPs, can act improve therapeutic results. Hence, appeared sustainable, biocompatible, nontoxic agent paved way futuristic biomedical investigations.

Language: Английский

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Enhancing Wound Healing with Nanohydrogel-Entrapped Plant Extracts and Nanosilver: An In Vitro Investigation

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5004 - 5004

Published: Oct. 22, 2024

Wound healing is a complex process that can be improved through advanced biomedical approaches. Incorporating nanopolymers and plant extracts into wound dressings offers favorable strategy for promoting tissue repair. Nanopolymers provide controlled environment sustained drug release while also protecting the from external contaminants. When combined with bioactive compounds extracts, which possess antioxidant, anti-inflammatory, antimicrobial properties, this hybrid approach accelerate healing, reduce infection, improve regeneration. Hence, in study, we have synthesized alginate/gelatin hydrogel blended only nanosilver (Alg/gel-Ag) like aloe vera, curcumin, plantain peel extract,

Language: Английский

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Phytofabrication of silver nanoparticles using Ehretia rigida leaf aqueous extract, their characterization, antioxidant and antimicrobial activities.

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: unknown, P. 101059 - 101059

Published: Dec. 1, 2024

Language: Английский

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Green Biosynthesis of Nanoparticles Using Plant Extracts: Mechanisms, Advances, Challenges, and Applications

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 13, 2025

Language: Английский

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Dual Biopolymer Layer Using Nanoparticles with Active Substance Enclosed in Microcapsules: Innovative Solution for Slow Release of Ginkgo biloba L. Extract for Potential Therapies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3066 - 3066

Published: March 27, 2025

The dynamic development of various branches medicine and pharmacy, along with the emergence new preventive alternative therapies for diseases, creates opportunities solutions utilizing carriers active substances. Their therapeutic effect may occur through direct contact skin lesions or indirectly, where medicinal substances penetrate capillary network in deeper layers reach bloodstream. aim research was to obtain a matrix consisting two renewable-source polymers (chitosan ethylcellulose) core material derived from Ginkgo biloba green leaf extract (GBE). obtained ethylcellulose microcapsules encapsulated chitosan nanoparticles {Et[Ch(GB)NP]} were characterized respect size, shape, surface morphology (SEM microscopy), substance release kinetics (UV-VIS mathematical models). analyzed using UV-VIS spectroscopy models. released components assessed microbiologically activity against six bacterial strains fungal strains, as well chromatographically HPLC-ESI-QTOF-MS/MS fingerprinting. dual polymer layer exhibited slow material, which demonstrated microbiological activity. strongest antimicrobial effects observed Klebsiella pneumoniae Salmonella enteritidis, minimum inhibitory concentration (MIC) 410 µg/mL. double-layer structures more efficient physiological saline environment, best fit following zero-order model (regression coefficient R2 = 0.9939). show great potential applications medical industry. controlled properties antibacterial effectiveness make them promising carrier modern therapies.

Language: Английский

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Recent progress of Ag-TiO ₂ nanomaterials by atmospheric pressure microplasma technique

Radiation effects and defects in solids, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: April 2, 2025

Language: Английский

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Advanced Bioinspired Silver Nanoparticles Integrated into Polyherbal Gel for Enhanced Diabetic Foot Ulcer Regeneration

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Language: Английский

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Harnessing the Therapeutic Potential of Metallic Bionanoparticles

Advances in chemical and materials engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 203 - 216

Published: Nov. 1, 2024

The integration of nanotechnology and biological systems has led to the emerging field nanobiotechnology, particularly in development nanomedicine. This chapter demonstrates that MNPs synthesized from plant extracts, such as silver, gold, copper, zinc oxide nanoparticles, have significant therapeutic potential. Their antioxidant properties are crucial mitigating oxidative stress-related diseases, while anticancer activities facilitate targeted drug delivery enhanced cytotoxic effects against cancer cells. Additionally, antimicrobial offer a promising alternative combat antibiotic-resistant pathogens. Overall, green synthesis represents advancement nanomedicine, combining traditional medicinal knowledge with modern nanotechnology. approach potential revolutionize systems, reduce side conventional therapies, contribute new, effective treatments for various diseases.

Language: Английский

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Responsive silver orthophosphate nanoparticles for antibacterial and antibiofilm activity against uropathogens

Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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