Ethyl-Cellulose Nanosponges for Topical Delivery of Simvastatin with Preferential Skin Retention for Wound Healing in a Full-Thickness Wound Rat Model DOI Creative Commons

Samar Aboelazayem,

Maha M. A. Nasra, Heba M. K. Ebada

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: May 6, 2025

Abstract Novel topical nanosponges were implemented to improve the skin availability of simvastatin (SV) for treating full-thickness wounds while controlling scarring process. SV exhibits great potential in various diseases owing its antibacterial, antioxidant, anti-inflammatory, and immunomodulatory properties. However, poor oral bioavailability systemic side effects have hindered clinical application dermatology. For first time, utilized target injured skin, creating an reservoir within wound bed enhance therapeutic efficacy minimizing adverse effects. Herein, SV-loaded ethyl-cellulose (SV-NS) prepared using emulsion solvent evaporation technique, optimizing organic solvents, concentration, stabilizer concentration. The selected SV-NS (20 mg SV) exhibited nanoporous particles (786.2 ± 50 nm), a specific surface area 10.3 m 2 /g, total pore volume 0.016 cm 3 offering sustained release enhanced retention capacity. In vivo studies on rat confirmed that (5 SV, applied every 5 days) significantly accelerated closure ( P < 0.0001), achieving 76.23 3.20% by day 8, 47% improvement over free SV. Consequently, facilitated exceeding 90% 11, whereas required 16 days attain comparable level, representing 31.2% faster healing rate. Histological analysis further revealed promoted optimal epidermal layer formation well-organized collagen deposition, with expression 0.0001) reaching 59.85 3.17% 16. Conclusively, enhances SV’s dermal availability, improving effects, demonstrating promising approach restoration. Graphical

Language: Английский

Ethyl-Cellulose Nanosponges for Topical Delivery of Simvastatin with Preferential Skin Retention for Wound Healing in a Full-Thickness Wound Rat Model DOI Creative Commons

Samar Aboelazayem,

Maha M. A. Nasra, Heba M. K. Ebada

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: May 6, 2025

Abstract Novel topical nanosponges were implemented to improve the skin availability of simvastatin (SV) for treating full-thickness wounds while controlling scarring process. SV exhibits great potential in various diseases owing its antibacterial, antioxidant, anti-inflammatory, and immunomodulatory properties. However, poor oral bioavailability systemic side effects have hindered clinical application dermatology. For first time, utilized target injured skin, creating an reservoir within wound bed enhance therapeutic efficacy minimizing adverse effects. Herein, SV-loaded ethyl-cellulose (SV-NS) prepared using emulsion solvent evaporation technique, optimizing organic solvents, concentration, stabilizer concentration. The selected SV-NS (20 mg SV) exhibited nanoporous particles (786.2 ± 50 nm), a specific surface area 10.3 m 2 /g, total pore volume 0.016 cm 3 offering sustained release enhanced retention capacity. In vivo studies on rat confirmed that (5 SV, applied every 5 days) significantly accelerated closure ( P < 0.0001), achieving 76.23 3.20% by day 8, 47% improvement over free SV. Consequently, facilitated exceeding 90% 11, whereas required 16 days attain comparable level, representing 31.2% faster healing rate. Histological analysis further revealed promoted optimal epidermal layer formation well-organized collagen deposition, with expression 0.0001) reaching 59.85 3.17% 16. Conclusively, enhances SV’s dermal availability, improving effects, demonstrating promising approach restoration. Graphical

Language: Английский

Citations

0