Defining the transcriptional routes controlling lncRNA NEAT1 expression: implications in cellular stress response, inflammation, and differentiation DOI Creative Commons
Sara De Domenico, Veronica La Banca, Silvia D’Amico

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 14, 2025

NEAT1 (Nuclear Enriched Abundant Transcript 1) is a long non-coding RNA playing critical role in both physiological and pathological settings by directly modulating variety of biological events, including transcriptional regulation, processing, chromatin remodeling. Multiple evidence demonstrated that different transcription factors signaling pathways modulate processes tightly regulating expression. These regulatory mechanisms act at levels, allowing cells to rapidly expression dynamically respond sudden changes cellular conditions. In this review, we summarize discuss the routes controlling expression, emphasizing recent showing pivotal important processes, such as stress response, inflammation, cell differentiation.

Language: Английский

Insights into the molecular and genetic role of obesity in breast cancer pathogenesis DOI Creative Commons
Sandeep Mallya,

V. Gangadhar,

Sophia Evangeline Aldrin

et al.

Cancer Biology & Therapy, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 12, 2025

The epidemic of obesity is a growing concern and one the major risk factors for several chronic diseases, including types cancers. correlation breast cancer with has been extensively studied involves an interplay hormonal, metabolic, genetic explored in this review. Inflammation hormone dysregulation play important role promoting protumorigenic environment through adipose tissue, which involved energy storage functions as endocrine organ. As result, various cytokines, primarily proinflammatory nature, are released, resulting low-grade inflammation tumor growth. Additionally, obese conditions also induce imbalances hormones, particularly estrogen insulin, both drive carcinogenesis. Genetic components such single nucleotide polymorphisms critical roles modulating between cancer. This review provides comprehensive overview mechanisms underlying incidence progression.

Language: Английский

Citations

0
Defining the transcriptional routes controlling lncRNA NEAT1 expression: implications in cellular stress response, inflammation, and differentiation DOI Creative Commons
Sara De Domenico, Veronica La Banca, Silvia D’Amico

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 14, 2025

NEAT1 (Nuclear Enriched Abundant Transcript 1) is a long non-coding RNA playing critical role in both physiological and pathological settings by directly modulating variety of biological events, including transcriptional regulation, processing, chromatin remodeling. Multiple evidence demonstrated that different transcription factors signaling pathways modulate processes tightly regulating expression. These regulatory mechanisms act at levels, allowing cells to rapidly expression dynamically respond sudden changes cellular conditions. In this review, we summarize discuss the routes controlling expression, emphasizing recent showing pivotal important processes, such as stress response, inflammation, cell differentiation.

Language: Английский

Citations

0