Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma DOI Creative Commons

Pengxiang Gao,

Qiuping Liu,

Zuojie Luo

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

Introduction Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) resulting from chronic hepatitis B virus (HBV) infection are major health concerns. Identifying critical biomarkers molecular targets is needed for early diagnosis, prognosis, therapy of these diseases. Methods In this study, we explored the gene expression metabolism in liver tissues LC, HCC, healthy controls, to analyse identify potential disease progression. Mass spectrometry imaging was used evaluate spatial distribution key metabolites. Results discussion The results revealed significant changes metabolic pathways along with upregulated genes were associated extracellular matrix remodeling cancer pathways, including LAMC1-3, COL9A2, COL1A1, MYL9, MYH11, KAT2A. downregulated linked immune response fatty acid metabolism. Metabolomic analysis showed lipid choline Consistent specific metabolites correlated clinical data. Notably, such as L-acetylcarnitine, histamine, 4-trimethylammoniobutanoic demonstrated high accuracy (AUC > 0.85) distinguishing between healthy, HCC groups. This study identifies metabolite HBV related LC highlighting involved Biomarkers like L-acetylcarnitine KAT2A show promise diagnosis potentially improving outcomes patients.

Language: Английский

The impact of metabolic syndrome on hepatocellular carcinoma: a mendelian randomization study DOI Creative Commons

Chendong Yuan,

Xufeng Shu,

Xiaoqiang Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 14, 2025

Traditional epidemiological studies are susceptible to confounding factors. To clarify the impact of metabolic syndrome and its diagnostic components on hepatocellular carcinoma, we conducted a preliminary mendelian randomization analysis with as exposures carcinoma outcome. Another set genetic data related was used validation cohort, repeating combining two groups for meta-analysis. Preliminary showed that (P-value = 0.002) waist circumference 0.026) significantly positively correlated an increased risk carcinoma. After multiple testing corrections, (PFDR-value 0.013) remained significant, although association between 0.079) considered suggestive, meta-analysis further confirmed 0.0002) 0.0038) in increasing adjusting predictive effects all exposures, found be key factor influencing relationship In summary, our study indicates increases particularly among individuals larger circumference.

Language: Английский

Citations

0
Lipid Metabolism and Immune Response in Hepatocellular Carcinoma: Interplay Driving Tumor Progression DOI Creative Commons
Tiffany Ching-Yun Yu, Yu‐Man Tsui, Xin Zhang

et al.

Published: April 4, 2025

With the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), it has become a significant risk factor for hepatocellular carcinoma (HCC). This review focuses on roles lipid metabolism aberrations and reprogramming in HCC development. We begin with brief overview relevant lipids to HCC, including fatty acyls, glycerolipids, glycerophospholipids sterol lipids, discuss particularly how associated its promotes chemoresistance HCC. then explore heterogeneity distribution across different stages includes intra-tissue spatial histological structure zonated regions liver, interpatient tumor at various degrees resolutions, from single cell bulk tissue levels. Next, we describe plasticity MASLD advent immunotherapy also examine relationship between anti-tumor immunity Finally, address challenges future perspectives targeting as dual approach improve treatment.

Language: Английский

Citations

0
Association between insulin glargine and risk of cancer: an updated and comprehensive systematic review and meta-analysis of observational studies DOI

Diar Zooravar,

Haleh Chehrehgosha,

Pedram Soltani

et al.

International Journal of Diabetes in Developing Countries, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Language: Английский

Citations

0
Hepatocyte nuclear factor 1 alpha variants as risk factor for hepatocellular carcinoma development with and without diabetes mellitus DOI

Isis Samy Bedira,

Ibrahim El Tantawy El Sayed,

Olfat Hendy

et al.

Gene Reports, Journal Year: 2024, Volume and Issue: 37, P. 102078 - 102078

Published: Nov. 1, 2024

Language: Английский

Citations

0
Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma DOI Creative Commons

Pengxiang Gao,

Qiuping Liu,

Zuojie Luo

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

Introduction Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) resulting from chronic hepatitis B virus (HBV) infection are major health concerns. Identifying critical biomarkers molecular targets is needed for early diagnosis, prognosis, therapy of these diseases. Methods In this study, we explored the gene expression metabolism in liver tissues LC, HCC, healthy controls, to analyse identify potential disease progression. Mass spectrometry imaging was used evaluate spatial distribution key metabolites. Results discussion The results revealed significant changes metabolic pathways along with upregulated genes were associated extracellular matrix remodeling cancer pathways, including LAMC1-3, COL9A2, COL1A1, MYL9, MYH11, KAT2A. downregulated linked immune response fatty acid metabolism. Metabolomic analysis showed lipid choline Consistent specific metabolites correlated clinical data. Notably, such as L-acetylcarnitine, histamine, 4-trimethylammoniobutanoic demonstrated high accuracy (AUC > 0.85) distinguishing between healthy, HCC groups. This study identifies metabolite HBV related LC highlighting involved Biomarkers like L-acetylcarnitine KAT2A show promise diagnosis potentially improving outcomes patients.

Language: Английский

Citations

0