Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 11, 2024
Lung squamous cell carcinoma is typically associated with a poor prognosis, highlighting the need for reliable prognostic marker. Given that long noncoding RNA TPT1-AS1 has demonstrated aberrant expression in numerous cancers, significance of LUSC was examined.
Language: Английский
Neuroscience, Journal Year: 2024, Volume and Issue: 553, P. 1 - 18
Published: June 27, 2024
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 471 - 471
Published: April 4, 2025
Noncoding RNAs (ncRNAs) are a heterogeneous group of RNA molecules whose classification is mainly based on arbitrary criteria such as the molecule length, secondary structures, and cellular functions. A large fraction these ncRNAs play regulatory role regarding messenger (mRNAs) or other ncRNAs, creating an intracellular network cross-interactions that allow fine complex regulation gene expression. Altering balance between interactions may be sufficient to cause transition from health disease vice versa. This leads possibility intervening in mechanisms re-establish patients. The associated with all cancer hallmarks, proliferation, apoptosis, invasion, metastasis, genomic instability. Based function performed carcinogenesis, behave either oncogenes tumor suppressors. However, this distinction not rigid; some can fall into both classes depending tissue considered target molecule. Furthermore, them also involved regulating response traditional cancer-therapeutic approaches. In general, molecular by very still largely unclear, but it has enormous potential for development new therapies, especially cases where methods fail, their use novel more efficient biomarkers. Overall, review will provide brief overview human biology, specific focus describing most recent ongoing clinical trials (CT) which have been tested therapeutic agents evaluated
Language: Английский
Citations
0
Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 891 - 908
Published: May 1, 2025
DDX11 antisense RNA 1 (DDX11-AS1) has been recognized for its strong correlation with hepatocellular carcinoma (HCC). Nevertheless, the exact biological functions and fundamental molecular processes of DDX11-AS1 in HCC require further in-depth investigation. A comprehensive bioinformatics analysis was carried out to explore expression clinical implication utilizing TCGA data. qRT-PCR employed validate tissues/cell lines. fluorescence situ hybridization (RNA-FISH) used observe subcellular localization cells. Loss-of-function experiments, both vitro vivo, were executed elucidate HCC. sequencing (RNA-seq) identify genes signaling pathways potentially regulated by DDX11-AS1. Rescue experiments conducted that carbonic anhydrase IX (CA9) mediates promoting progression. The influence nuclear respiratory factor (NRF1) on transcription investigated through dual-luciferase reporter assays ChIP-qPCR. increased is positively associated several aggressive characteristics (pathologic T stage, histologic grade, AFP level, vascular invasion), closely linked unfavorable outcomes patients, acting as a separate hazardous overall survival. predominantly situated nucleus knockdown impeded growth, migration, invasion capabilities cells vitro, reduced tumor enlargement subcutaneous mouse model. RNA-Seq unveiled silencing lessened CA9 suppressed activity MEK/ERK cascade uncovered acts downstream target facilitating cancer-causing roles Furthermore, revealed be transcriptionally NRF1. DDX11-AS1, NRF1-induced lncRNA, facilitates development upregulating activating cascade.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 13, 2025
Language: Английский
Citations
0
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155746 - 155746
Published: Nov. 28, 2024
Language: Английский
Citations
1
Medicine, Journal Year: 2024, Volume and Issue: 103(43), P. e40167 - e40167
Published: Oct. 25, 2024
Aggressive clear cell renal carcinoma (ccRCC) has a bad prognosis. We seek new ccRCC biomarkers for diagnosis and treatment. used exoRBase The Cancer Genome Atlas Database to compare DEmRNAs, DEmiRNAs, DElncRNAs, DEcircRNAs in normal tissues. CircRNAs circRNAs targeting microRNAs (miRNAs) were anticipated taken intersections, several databases assessed the targeted link between common miRNAs messenger RNAs (mRNAs). database was create predictive mRNA signature that validated E-MTAB-1980. Finally, we examined competing endogenous RNA network long noncoding using overall survival analysis. built first regulation of circRNA–lncRNA–miRNA–mRNA found it substantially correlates with unveiled ccRCC’s posttranscriptional mechanism greater detail. Our findings identified novel diagnosis, therapy,
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 11, 2024
Lung squamous cell carcinoma is typically associated with a poor prognosis, highlighting the need for reliable prognostic marker. Given that long noncoding RNA TPT1-AS1 has demonstrated aberrant expression in numerous cancers, significance of LUSC was examined.
Language: Английский
Citations
0