Administration of Spermidine and Eugenol Demonstrates Anti-Tumorigenic Efficacy on Metastatic SW620 and Primary Caco-2 Colorectal Cancer Spheroids DOI Open Access

Silvia Dilloo,

Anne Whittaker,

Xinyue Chang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13362 - 13362

Published: Dec. 13, 2024

The anti-cancer potential of eugenol (EUG) is well recognized, whereas that spermidine (SPD) subject to dispute and requires further research. anti-tumorigenic wheat germ SPD (150 µM) clove EUG (100 µM), alone, in combination as SPD+EUG (50 µM + 100 and, a supplement (SUPPL; 0.6 50 EUG), was investigated on both metastatic SW620 primary Caco-2 colorectal cancer (CRC) spheroids. Compared untreated controls, all treatments significantly reduced the vitality spheroid area, increased necrotic induced apoptosis cell-type spheroids after 96 h, with migration evident 2D (two-dimensional) cultures 48 h. comparable anti-CRC effects SUPPL reflected wide-range dose efficacy EUG. It note synergistic effect caspase-3 expression percentage SW620. In more physiologically relevant intestinal equivalents (healthy enterocytes [NCM460], fibroblasts [L929], monocytes [U937]) containing embedded SW620/Caco-2 spheroids, administration CEA marker proliferation, whilst simultaneously increasing occludin, autophagy LC3-II expression, monocyte differentiation, compared control models. Exogenous SPD, alone EUG, displayed an tumor growth metastasis, warrants investigation.

Language: Английский

Plant-Derived Molecules Modulate Multidrug Resistance in Gastrointestinal Cancers: A Comprehensive Review DOI Creative Commons
Gloria Perazzoli, Cristina Mesas, Francisco Quiñonero

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 1125 - 1125

Published: Jan. 23, 2025

Multidrug resistance (MDR) development against cytotoxic drugs by tumor cells is one of the main causes treatment failure in gastrointestinal cancers, a group cancers great relevance due to their prevalence and/or mortality. This phenomenon mediated diverse mechanisms, including overexpression members superfamily membrane transporters ATP-binding cassette (ABC). Most these molecules, P-glycoprotein (P-gp or MDR1/ABCB), MDR-associated protein 1 (MRP1/ABCC1), MRP2, and breast cancer (BCRP/ABCG2), are integrated cell membrane, acting as drug efflux pumps. Despite use various MDR modulators adjuvants improve chemotherapy response, results have not been satisfactory. Natural products from plants, such flavonoids, alkaloids, terpenoids, coumarins, capable modifying resistance, suggesting an improvement antitumoral effect current treatments without generating side effects. review aims provide overview most recent studies relation plant-derived molecules extracts that modulate antitumor could be applied future clinical practice patients with cancer.

Language: Английский

Citations

0
Advancing Mental Health through Culturally Sensitive Early Psychosis Intervention DOI
Ali Fakhrudin, Donal Donal,

Siska Mardes

et al.

Asian Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 106, P. 104412 - 104412

Published: Feb. 24, 2025

Language: Английский

Citations

0
Host genetics-associated mechanisms in colorectal cancer DOI
Adriana González, Asier Fullaondo,

Adrián Odriozola

et al.

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 122

Published: Jan. 1, 2024

Language: Английский

Citations

0
Epigenetic modulation of autophagy pathway by small molecules in colorectal cancer: a systematic review DOI Creative Commons
Mozhdeh Zamani, Farima Safari, Morvarid Siri

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(10)

Published: Oct. 23, 2024

Colorectal cancer (CRC) remains a global health challenge with limited treatment success due to drug resistance. Recent research highlights the potential of small molecules modulate CRC by targeting epigenetics or autophagy pathways. This systematic review explores epigenetic effect on in CRC, aiming identify novel therapeutic strategies. Following PRISMA guidelines, we systematically reviewed 508 studies from PubMed, Scopus, and Web Science databases until August 13, 2023. Eight met inclusion criteria, examining role as modulators (Histone acetylation/deacetylation, DNA methylation/demethylation gene expression regulation miRNAs) influencing pathway CRC. The encompassed vitro animal model vivo studies. Small exhibited diverse effects For instance, panobinostat promoted leading cell death, while aspirin inhibited flux, reducing aspirin-mediated death. modulation various differently affects their anticancer effect, which underscores complexity interventions. Understanding intricate dynamics among molecules, modifications, is crucial for developing targeted Considering dual tumorigenesis tumor suppression, administration these may affect fate response resistance based pathway. Therefore, recognition mechanism contribute deciding how prescribe them better treatment.

Language: Английский

Citations

0
Administration of Spermidine and Eugenol Demonstrates Anti-Tumorigenic Efficacy on Metastatic SW620 and Primary Caco-2 Colorectal Cancer Spheroids DOI Open Access

Silvia Dilloo,

Anne Whittaker,

Xinyue Chang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13362 - 13362

Published: Dec. 13, 2024

The anti-cancer potential of eugenol (EUG) is well recognized, whereas that spermidine (SPD) subject to dispute and requires further research. anti-tumorigenic wheat germ SPD (150 µM) clove EUG (100 µM), alone, in combination as SPD+EUG (50 µM + 100 and, a supplement (SUPPL; 0.6 50 EUG), was investigated on both metastatic SW620 primary Caco-2 colorectal cancer (CRC) spheroids. Compared untreated controls, all treatments significantly reduced the vitality spheroid area, increased necrotic induced apoptosis cell-type spheroids after 96 h, with migration evident 2D (two-dimensional) cultures 48 h. comparable anti-CRC effects SUPPL reflected wide-range dose efficacy EUG. It note synergistic effect caspase-3 expression percentage SW620. In more physiologically relevant intestinal equivalents (healthy enterocytes [NCM460], fibroblasts [L929], monocytes [U937]) containing embedded SW620/Caco-2 spheroids, administration CEA marker proliferation, whilst simultaneously increasing occludin, autophagy LC3-II expression, monocyte differentiation, compared control models. Exogenous SPD, alone EUG, displayed an tumor growth metastasis, warrants investigation.

Language: Английский

Citations

0