Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application DOI Creative Commons
Lin Su, Jiawen Bu, Jiahui Yu

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(11)

Published: Oct. 27, 2024

Abstract Hepatocellular carcinoma (HCC) is a primary malignant tumour, ranking second in global mortality rates and posing significant health threats. Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis progression. However, comprehensive analysis of the methylation mechanism driving progression its potential therapeutic biomarker remains lacking. This review attempts to comprehensively summarise various aspects such mechanism, detection methods biomarkers aiding treatment prognostic assessment HCC. It also explores role regulating HCC's sorafenib resistance, alongside elaborating effects methyltransferase inhibitors on A detailed examination these underscores research tumour cells elucidate mechanisms, identify diagnostic markers develop new tumour‐specific for Key points summary diagnosis treatment. The hepatocellular carcinoma's inhibitors. Deep critical discovering novel

Language: Английский

Mechanisms and technologies in cancer epigenetics DOI Creative Commons
Zaki A. Sherif, Olorunseun O. Ogunwobi, Habtom W. Ressom

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 7, 2025

Cancer's epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review discusses the intricate mechanisms underlying cancer epigenetics, unraveling complex interplay between DNA methylation, histone chromatin remodeling, non-coding RNAs. We navigate through tumultuous seas dysregulation, exploring how these processes conspire to silence tumor suppressors unleash oncogenic potential. The narrative pivots cutting-edge technologies, revolutionizing our ability decode epigenome. From granular insights single-cell epigenomics holistic view offered by multi-omics approaches, we examine tools are reshaping understanding heterogeneity evolution. also highlights emerging techniques, such as spatial long-read sequencing, which promise unveil hidden dimensions regulation. Finally, probed transformative potential CRISPR-based epigenome editing computational analysis transmute raw data into biological insights. study seeks synthesize comprehensive yet nuanced contemporary landscape future directions research.

Language: Английский

Citations

0
Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application DOI Creative Commons
Lin Su, Jiawen Bu, Jiahui Yu

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(11)

Published: Oct. 27, 2024

Abstract Hepatocellular carcinoma (HCC) is a primary malignant tumour, ranking second in global mortality rates and posing significant health threats. Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis progression. However, comprehensive analysis of the methylation mechanism driving progression its potential therapeutic biomarker remains lacking. This review attempts to comprehensively summarise various aspects such mechanism, detection methods biomarkers aiding treatment prognostic assessment HCC. It also explores role regulating HCC's sorafenib resistance, alongside elaborating effects methyltransferase inhibitors on A detailed examination these underscores research tumour cells elucidate mechanisms, identify diagnostic markers develop new tumour‐specific for Key points summary diagnosis treatment. The hepatocellular carcinoma's inhibitors. Deep critical discovering novel

Language: Английский

Citations

3