Impact of time‐of‐day atezolizumab plus bevacizumab combination therapy infusion for unresectable hepatocellular carcinoma: A retrospective multicenter study
Hepatology Research,
Journal Year:
2025,
Volume and Issue:
55(5), P. 741 - 751
Published: Feb. 9, 2025
Abstract
Aim
This
study
aimed
to
evaluate
the
impact
of
infusion
timing
time‐of‐day
on
clinical
outcomes
in
patients
with
unresectable
hepatocellular
carcinoma
(HCC)
treated
atezolizumab
plus
bevacizumab
combination
therapy.
Methods
A
retrospective
analysis
was
conducted
using
data
from
751
HCC
between
September
2020
and
April
2024.
Patients
were
categorized
into
morning
(AM;
n
=
351)
afternoon
(PM;
400)
groups
based
time‐of‐day.
Outcomes,
including
progression‐free
survival
(PFS),
overall
survival,
objective
response
rate,
disease
control
assessed
Kaplan–Meier
Cox
regression
analysis.
Results
The
PFS
significantly
longer
AM
group
(8.6
months,
95%
CI
7.6–10.5)
compared
PM
(6.0
5.4–7.0;
p
0.006).
In
contrast,
similar
(AM:
24.7
months
vs.
PM:
21.4
months;
0.99).
revealed
that
an
independent
favorable
predictor
(HR
1.23,
1.04–1.45).
Additionally,
demonstrated
superior
rate
group,
suggesting
better
tumor
control.
Conclusion
Morning
is
associated
improved
rates
patients,
highlighting
potential
for
optimizing
treatment
through
circadian
timing.
Language: Английский
Rhythms in Remodeling: Posttranslational Regulation of Bone by the Circadian Clock
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 705 - 705
Published: March 13, 2025
The
circadian
clock
is
a
fundamental
timekeeping
system
that
regulates
rhythmic
biological
processes
in
response
to
environmental
light–dark
cycles.
In
mammals,
core
genes
(CLOCK,
BMAL1,
PER,
and
CRY)
orchestrate
these
rhythms
through
transcriptional–translational
feedback
loops,
influencing
various
physiological
functions,
including
bone
remodeling.
Bone
homeostasis
relies
on
the
coordinated
activities
of
osteoblasts,
osteoclasts,
osteocytes,
with
increasing
evidence
highlighting
role
regulation
maintaining
skeletal
integrity.
Disruptions
are
linked
disorders
such
as
osteoporosis.
Posttranslational
modifications
(PTMs),
phosphorylation,
acetylation,
ubiquitination,
serve
crucial
regulators
both
mechanisms
metabolism.
However,
specific
PTMs
integrating
timing
remodeling
remains
underexplored.
This
review
examines
intersection
biology,
elucidating
their
impact
cell
function
homeostasis.
Understanding
interactions
may
uncover
novel
therapeutic
targets
for
diseases
associated
disruptions.
Language: Английский