Long Non-Coding TP73-AS1: A Potential Biomarker and Therapeutic Target in Cancer DOI Open Access
Kejing Li, Dapeng Zhao, Xuena Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3886 - 3886

Published: April 20, 2025

Tumor protein 73 antisense RNA 1 (TP73-AS1), a newly discovered long non-coding (lncRNA), the dysregulated expression of which is closely related to occurrence, drug resistance, and prognosis various cancers. Exploring regulatory mechanism TP73-AS1 provides new research direction for cancer diagnosis treatment. On this basis, we briefly review molecular structural dual roles in cancer. In addition, outline its three mechanisms cancer: binding proteins, regulating signaling pathways, serving as sponges. Subsequently, introduce role common malignant tumors such gastric (GC), lung cancer, colorectal (CRC), etc. Last, emphasis given potential clinical value TP73-AS1, especially single nucleotide polymorphisms lncRNA are associated with risk GC CRC. Therefore, highlights significance novel biomarker therapeutic target.

Language: Английский

Long Non-Coding TP73-AS1: A Potential Biomarker and Therapeutic Target in Cancer DOI Open Access
Kejing Li, Dapeng Zhao, Xuena Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3886 - 3886

Published: April 20, 2025

Tumor protein 73 antisense RNA 1 (TP73-AS1), a newly discovered long non-coding (lncRNA), the dysregulated expression of which is closely related to occurrence, drug resistance, and prognosis various cancers. Exploring regulatory mechanism TP73-AS1 provides new research direction for cancer diagnosis treatment. On this basis, we briefly review molecular structural dual roles in cancer. In addition, outline its three mechanisms cancer: binding proteins, regulating signaling pathways, serving as sponges. Subsequently, introduce role common malignant tumors such gastric (GC), lung cancer, colorectal (CRC), etc. Last, emphasis given potential clinical value TP73-AS1, especially single nucleotide polymorphisms lncRNA are associated with risk GC CRC. Therefore, highlights significance novel biomarker therapeutic target.

Language: Английский

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