Genetically engineered neural stem cells (NSCs) therapy for neurological diseases; state‐of‐the‐art DOI
Ghufran Lutfi Ismaeel,

Olfet Jabbar Makki AlHassani,

Reem S. Alazragi

et al.

Biotechnology Progress, Journal Year: 2023, Volume and Issue: 39(5)

Published: May 23, 2023

Abstract Neural stem cells (NSCs) are multipotent with remarkable self‐renewal potential and also unique competencies to differentiate into neurons, astrocytes, oligodendrocytes (ODCs) improve the cellular microenvironment. In addition, NSCs secret diversity of mediators, including neurotrophic factors (e.g., BDNF, NGF, GDNF, CNTF, NT‐3), pro‐angiogenic mediators FGF‐2 VEGF), anti‐inflammatory biomolecules. Thereby, transplantation has become a reasonable effective treatment for various neurodegenerative disorders by their capacity induce neurogenesis vasculogenesis dampen neuroinflammation oxidative stress. Nonetheless, drawbacks such as lower migration survival less differential particular cell lineage concerning disease pathogenesis hinder application. Thus, genetic engineering before is recently regarded an innovative strategy bypass these hurdles. Indeed, genetically modified could bring about more favored therapeutic influences post‐transplantation in vivo, making them excellent option neurological therapy. This review first time offers comprehensive capability rather than naïve beyond brain tumors sheds light on recent progress prospect this context.

Language: Английский

Leptin Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells through the Cooperative Action of MAPK/ERK1/2, JAK2/STAT3 and PI3K/AKT Signaling Pathways DOI Open Access

Ruolan Tan,

Xiaoxuan Hu, Xinyi Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15151 - 15151

Published: Oct. 13, 2023

The potential of neural stem cells (NSCs) for neurological disorders the treatment has relied in large part upon identifying NSCs fate decision. hormone leptin been reported to be a crucial regulator brain development, able influence glial and yet, underlying mechanism acting on NSCs' biological characteristics is still poorly understood. This study aims investigate role properties NSCs. In this study, we possibility that may regulate decision, which promote proliferation neuronal differentiation thus act positively disorders. from embryonic cerebral cortex were used study. We CCK-8 assay, ki67 immunostaining, FACS analysis confirm 25-100 ng/mL promotes concentration-dependent pattern. change was accompanied by upregulation p-AKT p-ERK1/2, are classical downstream signaling pathways receptors b (LepRb). Inhibition PI3K/AKT or MAPK/ERK both abolished effect leptin-induced proliferation. Moreover, also enhanced directed A blockade pathway reversed leptin-stimulated neurogenesis, while JAK2/STAT3 had no it. Taken together, our results support regulating promoting proliferation, could promising approach repair via

Language: Английский

Citations

10
A taurine-based hydrogel with the neuroprotective effect and the ability to promote neural stem cell proliferation DOI
Zhichao Wang,

Chuanzhen Huang,

Zhenyu Shi

et al.

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 161, P. 213895 - 213895

Published: May 21, 2024

Language: Английский

Citations

4
Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells DOI Creative Commons

Nana Tan,

Wenqiang Xin, Min Huang

et al.

Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 8, 2022

Stroke, a cerebrovascular accident, is prevalent and the second highest cause of death globally across patient populations; it as significant morbidity mortality. Mesenchymal stem cell (MSC) transplantation emerging promising treatment for alleviating neurological deficits, indicated by great number animal clinical studies. The potential regulating immune system currently being explored therapeutic target after ischemic stroke. This study will discuss recent evidence that MSCs can harness interacting with cells to boost neurologic recovery effectively. Moreover, notion be given participating in multiple pathological processes, such increasing survival angiogenesis suppressing apoptosis autophagy several phases stroke, consequently promoting function recovery. We conclude review highlighting opportunities reviewing safety, feasibility, efficacy therapy.

Language: Английский

Citations

15
Stem cells in central nervous system diseases: Promising therapeutic strategies DOI Creative Commons

Caidi Ying,

Jiahao Zhang, Haocheng Zhang

et al.

Experimental Neurology, Journal Year: 2023, Volume and Issue: 369, P. 114543 - 114543

Published: Sept. 23, 2023

Central nervous system (CNS) diseases are a leading cause of death and disability. Due to CNS neurons have no self-renewal regenerative ability as they mature, their loss after injury or disease is irreversible often leads functional impairments. Unfortunately, therapeutic options for still limited, effective treatments these notorious warranted be explored. At present, stem cell therapy has emerged potential strategy improving the prognosis diseases. Accumulating preclinical clinical evidences demonstrated that multiple molecular mechanisms, such replacement, immunoregulation neurotrophic effect, underlie use However, several issues yet addressed support its application. Thus, this review article aims summarize role underlying mechanisms in treating And it worthy further evaluation applications treatment disease.

Language: Английский

Citations

9
Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke DOI Creative Commons
Jiangjun Zhang, Zhong Chen, Qi Chen

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1848 - 1848

Published: April 18, 2024

In recent years, the frequency of strokes has been on rise year by and become second leading cause death around world, which is characterized a high mortality rate, recurrence disability rate. Ischemic account for large percentage strokes. A reperfusion injury in ischemic complex cascade oxidative stress, neuroinflammation, immune infiltration, mitochondrial damage. Conventional treatments are ineffective, presence blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers turning their attention nano-drug systems. Functionalized systems have widely studied applied study cerebral diseases due favorable biocompatibility, efficiency, strong specificity, specific targeting ability. this paper, we briefly describe pathological process injuries focus therapeutic research progress strokes, aiming provide certain references understand (NDDSs).

Language: Английский

Citations

3
A review: Carrier-based hydrogels containing bioactive molecules and stem cells for ischemic stroke therapy DOI

Wenzhe Yin,

Yankai Jiang,

Guangrui Ma

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 39 - 62

Published: March 5, 2025

Language: Английский

Citations

0
Neurovascular unit in ischemic stroke in older adults: a narrative review DOI
Chengyuan Wang, Yi Yang, Tianqing Xiong

et al.

Aging advances., Journal Year: 2025, Volume and Issue: 2(1), P. 29 - 39

Published: Feb. 6, 2025

There is a significant global death and disability rate associated with ischemic stroke, making it one of the most prevalent disorders. With increasing worldwide aging population, prevalence stroke has notably increased emerged as pivotal issue in public health. The neurovascular unit primarily consists neurons, astrocytes, microglia, brain microvascular endothelial cells. These cells are structurally tightly connected; together, they maintain balance function crucial for cerebral damage. Emerging studies recent years have demonstrated development associations between vascular neural units. characterizes whole-tissue response to encompassing interrelationship reciprocal impact glial cells, microvessels. results compromised integrity microvasculature blood–brain barrier, neuronal cell death, response, inflammatory immune infiltration, all which strongly course stroke. This narrative review explores complex relationship context an population. aging, undergoes structural functional changes that predispose elderly higher risks complicate recovery post-stroke. We explore on unit, focusing how age-related alterations contribute susceptibility influence repair mechanisms highlights blood-brain barriers, heightened reactions, infiltration critical progression By examining latest research, we aim provide comprehensive understanding unit’s role within population discuss regenerative medicine offers novel strategies treatment, emphasizing neuroprotection, neuroregeneration, neurorepair. aspects paramount importance clinical interventions tailored elderly, who often present unique challenges management. underscores considering factor research cellular interactions form system significantly influenced by process. connections cannot be overlooked quest effective therapies. presents new perspectives particularly where traditional therapies may less or carry risks. aims bridge gap knowledge regarding providing foundation targeted can improve outcomes this vulnerable

Language: Английский

Citations

0
Bibliometric Analysis and Visualized Study of Research on Mesenchymal Stem Cells in Ischemic Stroke DOI Creative Commons

F. Bu,

Xinmei Yuan,

Xiao Cui

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

One of the major global causes death and disability is ischemic stroke (IS). Mesenchymal stem cells (MSCs) emerge as a cell-based therapy for numerous diseases. Recently, research on role MSCs in has developed rapidly worldwide. Bibliometric analysis IS not yet been published, though. Through bibliometric analysis, aim this study was to assess current state field worldwide identify important results, areas, emerging trends. Publications related from January 1, 2002, December 31, 2022, were obtained Web Science Core Collection (WoSCC). We used HistCite, VOSViewer, CiteSpace, Bibliometrix visualization. employed Total Global Citation Score (TGCS) impact publications. The included total 2,048 1,386 papers authored by 200 individuals across organizations 72 countries, published 202 journals. Cesar V Borlongan most documents among high-productivity authors. Michael Chopp author with highest average number citations per paper, an paper citation time 118.54. found that starting 2008. Neurosciences productive journals, Chinese researchers have produced subject. cited article "Systemic administration exosomes released mesenchymal stromal promotes functional recovery neurovascular plasticity after rats". This uses both numbers descriptions thoroughly review IS. information provides valuable experience carry out MSCs' work

Language: Английский

Citations

0
Cell membrane-coated nanoparticles: a biomimetic strategy for effective treatment of ischemic stroke DOI
M. Qi, Yanping Sun,

Zirui Zhao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106966 - 106966

Published: April 1, 2025

Language: Английский

Citations

0
The association of HIF1A gene polymorphism and its expression with ischemic stroke DOI Creative Commons
Fengjiao Yang, Yun Gu,

Ya Yan

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 26, 2025

Hypoxia-inducible factor 1 A (HIF1A) is considered as a potential marker gene for ischemic stroke (IS), its polymorphism may affect IS risk and be related to the pathological process. In this study, total of 159 patients 141 healthy controls were enrolled by case-control study method. HIF1A three single nucleotide polymorphisms (SNPs: rs10873142, rs11549465, rs11549467) genotyped SNaPshot method protein levels was detected enzyme-linked immunosorbent assay (ELISA), then correlation between HIF-1 SNPs analyzed statistical analysis The genotype can expression clinical laboratory parameters in patients, such high-density lipoproteincholesterol (HDL-C), apolipoprotein A1, reactive oxygen species (ROS). TCG haplotype protective IS, CCG IS. However, association rs11549467 genotypes not statistically significant. ELISA showed that higher than controls. Therefore, process, but relationship still needs further study.

Language: Английский

Citations

0