Oleuropein Protects against the Development of Kidneys Induced by Paracetamol in Albino Male Rats. DOI Creative Commons

Elham Ahmed Mejbel,

Saif Subhi Noori,

Adeeb Shakir Mahmood

et al.

HAYATI Journal of Biosciences, Journal Year: 2024, Volume and Issue: 32(1), P. 254 - 262

Published: Nov. 22, 2024

Paracetamol treatment is considered one of the treatments used to relieve pain and antipyretic. Therefore, excessive doses long-term use lead organ toxicity. The aim study was investigate protective effect Oleuropein extracted from olive leaves on physiological histological aspects induced by in a rat model. methods 25 albino Swiss rats randomly distributed into five groups with same number. unit control given normal saline. (750 mg/kg) injected group once. In (50 mg/kg, 100 150 mg/kg). Administration Paracetamol's result significantly increased blood urea, creatinine, sodium, potassium levels, their concentrations decreased (P 0.05). addition, relieved some symptoms, including acute vascular congestion caused dose Paracetamol. Compared paracetamol treatment, there an infiltration inflammatory cells severe nephrotoxicity tubules. According this study, can be prevent kidney damage, It not recommended give Paracetamol, which increases disorders.

Language: Английский

Computational Investigation of Graphyne Monolayer as a Promising Carrier for Anticancer Drug Delivery DOI
Ayman M. Al‐Qaaneh,

Munthar Kadhim Abosaoda,

Lalji Baldaniya

et al.

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: 115, P. 108369 - 108369

Published: Jan. 30, 2025

Language: Английский

Citations

0
Chlormethine drug adsorption on the zinc oxide nanotube surface for drug delivery system DOI
Mohamed J. Saadh, Mohammed Ahmed Mustafa, Shahad Mohammed Dhiaa

et al.

Adsorption, Journal Year: 2025, Volume and Issue: 31(3)

Published: Feb. 22, 2025

Language: Английский

Citations

0
The ability of ZnO and MgO nanocages for adsorption and sensing performance of anticancer drug detection DOI

Mohamed J. Saadh,

Ali B. M. Ali,

Zahraa A. Hanoon

et al.

Journal of Molecular Graphics and Modelling, Journal Year: 2025, Volume and Issue: 137, P. 109003 - 109003

Published: March 4, 2025

Language: Английский

Citations

0
DFT study of pure and Pt-decorated BN nanocone as a nanocarrier for nitrosourea anticancer drug DOI
Yousef A. Bin Jardan,

Fadhel F. Sead,

Dharmesh Sur

et al.

Journal of Molecular Graphics and Modelling, Journal Year: 2025, Volume and Issue: 137, P. 109018 - 109018

Published: March 14, 2025

Language: Английский

Citations

0
Anti-cancer chlorambucil drug delivery by Pt, Au, and Ir-decorated ZnO nanotubes DOI
Yousef A. Bin Jardan,

Abdulrahman T. Ahmed,

Mohammed Ahmed Mustafa

et al.

Solid State Communications, Journal Year: 2025, Volume and Issue: unknown, P. 115972 - 115972

Published: April 1, 2025

Language: Английский

Citations

0
EXOSOMES AS MEDIATORS OF NEUROINFLAMMATION IN PARKINSON'S DISEASE: A REVIEW DOI Open Access
Mujibullah Sheikh,

Arshiya Saiyyad,

Pranita Jirvankar

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 80 - 92

Published: May 7, 2025

Parkinson’s Disease (PD), a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, is closely associated with neuroinflammation mediated exosomes. This review discusses role exosomes in modulation neuroinflammatory processes PD. Small Extracellular Vesicles (EVs) are that communicate between cells transporting proteins, lipids, and RNAs affect neuronal health. We investigated how propagate misfolded α-synuclein proinflammatory mediators, leading to microglial activation neurodegeneration. The key questions addressed include following: (1) How do promote spread pathology? (2) What molecular pathways drive exosome-mediated PD? (3) Can serve as diagnostic biomarkers or therapeutic vehicles? By analyzing these mechanisms, this underscores dual exacerbating disease progression their potential for innovative treatments. finding highlights challenges current methodologies future prospects exosome-targeted therapy

Language: Английский

Citations

0
Oleuropein Protects against the Development of Kidneys Induced by Paracetamol in Albino Male Rats. DOI Creative Commons

Elham Ahmed Mejbel,

Saif Subhi Noori,

Adeeb Shakir Mahmood

et al.

HAYATI Journal of Biosciences, Journal Year: 2024, Volume and Issue: 32(1), P. 254 - 262

Published: Nov. 22, 2024

Paracetamol treatment is considered one of the treatments used to relieve pain and antipyretic. Therefore, excessive doses long-term use lead organ toxicity. The aim study was investigate protective effect Oleuropein extracted from olive leaves on physiological histological aspects induced by in a rat model. methods 25 albino Swiss rats randomly distributed into five groups with same number. unit control given normal saline. (750 mg/kg) injected group once. In (50 mg/kg, 100 150 mg/kg). Administration Paracetamol's result significantly increased blood urea, creatinine, sodium, potassium levels, their concentrations decreased (P 0.05). addition, relieved some symptoms, including acute vascular congestion caused dose Paracetamol. Compared paracetamol treatment, there an infiltration inflammatory cells severe nephrotoxicity tubules. According this study, can be prevent kidney damage, It not recommended give Paracetamol, which increases disorders.

Language: Английский

Citations

0