The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS DOI Creative Commons

Linlin Yang,

Jianhua Chen, Hui Miao

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315750 - e0315750

Published: Dec. 13, 2024

Polycystic ovary syndrome (PCOS) is a prevalent yet complex reproductive endocrine disorder affecting 11–13% of women worldwide. Its main symptoms include elevated androgen levels, irregular menstrual cycles, and long-term metabolic offspring health implications. Despite the disease’s multifaceted nature involving genetic, epigenetic, environmental factors, role alternative splicing in ovarian granulosa cells remains relatively unexplored. This study aims to investigate transcriptional characteristics PCOS patients elucidate potential functional consequences these changes. Analysis previous published transcriptome sequencing data identified 491 upregulated 401 downregulated genes patients, significantly involved immune-related processes. Additionally, 1250 differential events, predominantly exon skipping 947 genes, were detected. These with patterns found be enriched endoplasmic reticulum stress protein post-translational modification processes, suggesting their pathology. Moreover, highlighted that utilization different splice isoforms YAP1 gene may impact its interaction Hippo signaling pathway, influencing pathogenesis PCOS. findings underscore substantial alterations providing novel viewpoint for comprehending molecular underpinnings avenues therapeutic intervention.

Language: Английский

Artificial intelligence in ovarian cancer drug resistance advanced 3PM approach: subtype classification and prognostic modeling DOI
Cong Zhang,

Jinxiang Yang,

Siyu Chen

et al.

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(3), P. 525 - 544

Published: July 13, 2024

Language: Английский

Citations

6
The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS DOI Creative Commons

Linlin Yang,

Jianhua Chen, Hui Miao

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315750 - e0315750

Published: Dec. 13, 2024

Polycystic ovary syndrome (PCOS) is a prevalent yet complex reproductive endocrine disorder affecting 11–13% of women worldwide. Its main symptoms include elevated androgen levels, irregular menstrual cycles, and long-term metabolic offspring health implications. Despite the disease’s multifaceted nature involving genetic, epigenetic, environmental factors, role alternative splicing in ovarian granulosa cells remains relatively unexplored. This study aims to investigate transcriptional characteristics PCOS patients elucidate potential functional consequences these changes. Analysis previous published transcriptome sequencing data identified 491 upregulated 401 downregulated genes patients, significantly involved immune-related processes. Additionally, 1250 differential events, predominantly exon skipping 947 genes, were detected. These with patterns found be enriched endoplasmic reticulum stress protein post-translational modification processes, suggesting their pathology. Moreover, highlighted that utilization different splice isoforms YAP1 gene may impact its interaction Hippo signaling pathway, influencing pathogenesis PCOS. findings underscore substantial alterations providing novel viewpoint for comprehending molecular underpinnings avenues therapeutic intervention.

Language: Английский

Citations

0