Light Irradiation of N‐Doped Graphene Acid: Metal‐Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action

EcoMat, Journal Year: 2025, Volume and Issue: 7(4)

Published: March 26, 2025

ABSTRACT The increasing emergence of antimicrobial resistance and the development new infective viral strains represent a constantly growing threat. Metal‐based nanomaterials have emerged as promising tools in fight against bacterial infections; however, release metal nanoparticles/ions clinical applications may cause undesired side effects (allergies, systemic toxicity), reducing their practical use treatment. Moreover, metal‐based nanoparticles possess predominantly antibacterial effects, while antiviral efficiency remains controversial. Thus, metal‐free strategies enabling combined antibacterial/antiviral properties is significant challenge. Here, we report strategy based on light irradiation nitrogen‐doped graphene acid (NGA) possessing dual photothermal photodynamic modes action. activity activated through clinically approved near‐infrared (NIR) source, both spreading can be hampered coating scale minutes (5 to 10 min). developed reduced 90.9% 99.99% for S. aureus P. aeruginosa , respectively, well 99.97% murine hepatitis virus. Importantly, this research represents advancement safe, metal‐free, effective treatments. NGA coatings are safe skin, showing no sensitization or irritation, offer potential advanced

Language: Английский

Bile salt-enriched vs. non-enriched nanoparticles: comparison of their physicochemical characteristics and release pattern

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: 29(3), P. 187 - 211

Published: Feb. 19, 2024

Bile salts were first used in the preparation of nanoparticles due to their stabilizing effects. As time went by, they attracted much attention and increasingly employed fabricating nanoparticles. It is well accepted that physicochemical properties are influential factors permeation, distribution, elimination degree effectiveness as toxicity. The review articles shows use bile structure nanocarriers may cause significant changes properties. Hence, having information about effect on could be valuable design optimal carriers. Herein, we studies which preparing liposomes, niosomes other nanocarriers. Furthermore, effects entrapment efficiency, particle size, polydispersity index, zeta potential, release profile stability pointed out. Finally, debate how take advantage potential for desirable

Language: Английский