3 Biotech,
Journal Year:
2024,
Volume and Issue:
14(12)
Published: Nov. 28, 2024
Abstract
The
goal
of
the
research
was
to
develop
a
hydrophobic
octanoate
salt
chitosan
(CS–OA)
and
use
as
nanoparticle
platform
for
delivery
curcumin
(CUR)
into
prostate
cancer
cells.
nanoprecipitation
technique
used
prepare
nanoparticles,
which
were
measured
particle
size
encapsulation
efficacy
relative
CUR–CS
nanoparticles.
cytotoxicity
CUR–OA–CS
nanoparticles
evaluated
in
cancerous
cells
(PC3
DU145)
comparison
with
corresponding
blank
hydroalcoholic
CUR
solution.
PXRD,
SEM,
TEM
also
examine
CUR–CS–OA
average
diameters
268.90
±
3.77
nm
221.90
2.79
nm,
respectively,
efficiencies
61.37
1.70%
60.20
3.17%.
PXRD
SEM
suggested
amorphization
CS–OA
void
exhibited
concentration-dependent
antiproliferative
action,
attributed
cellular
uptake
CS.
loading
these
increased
their
even
more.
potential
special
system
additional
cytotoxic
drugs
different
malignant
can
be
further
explored.
Journal of Nanotheranostics,
Journal Year:
2025,
Volume and Issue:
6(2), P. 11 - 11
Published: April 9, 2025
Theranostic
nanoparticles
integrate
diagnostic
and
therapeutic
potential,
representing
a
promising
approach
in
precision
medicine.
Accordingly,
numerous
inventions
have
been
patented
to
protect
novel
formulations
methods.
This
review
examines
the
evolution
of
theranostic
nanoparticles,
focusing
on
organic
nanosystems,
particularly
polymeric
lipid
assess
their
development,
technological
advances,
patentability.
A
scoping
was
conducted
following
Preferred
Reporting
Items
for
Systematic
reviews
Meta-Analyses
(PRISMA)
guidelines
World
Intellectual
Property
Organization
(WIPO)
European
Patent
Office
(EPO)
database.
The
search
included
patents
filed
within
last
ten
years
(2014–2024)
that
specifically
claimed
and/or
hybrid
nanoparticles.
Data
extraction
focused
nanoparticle
composition,
synthesis
methods,
functionalization
strategies,
applications.
identified
130
patents,
which
13
met
inclusion
criteria.
These
were
primarily
by
inventors
from
United
States,
Canada,
Great
Britain,
Italy,
China.
Polymeric
frequently
engineered
targeted
drug
delivery
imaging,
utilizing
hyperbranched
polyesters,
sulfated
polymers,
or
chitosan-based
formulations.
Lipid
often
hybridized
with
inorganic
nanomaterials
magnetic
nanostructures
enhance
potential.
While
most
detailed
methods
physicochemical
characterizations,
only
few
provided
comprehensive
preclinical
validation,
limiting
demonstrated
efficacy.
analysis
recent
highlights
significant
advances
design
application
However,
notable
gap
remains
validating
these
nanosystems
clinical
translation.
Future
efforts
should
emphasize
robust
data,
including
vitro
vivo
assessments,
patent
quality
applicability
substantiate
capabilities.
Computer Methods in Biomechanics & Biomedical Engineering,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 25
Published: May 1, 2025
A
nano-blood
model
is
developed
to
study
the
flow
of
gold-
and
silver-infused
blood
through
a
porous,
stenotic
artery
under
Newtonian
assumptions.
Wall
curvature,
convective
heating,
wall
motion,
viscous
dissipation
are
considered.
Darcy's
simulates
porous
resistance,
Tiwari-Das
captures
nanoparticle
effects.
Governing
equations
reduced
via
similarity
transformations
solved
using
MATLAB's
bvp4c
solver.
Validation
against
existing
studies
provided.
Results
show
gold-blood
nanofluid
achieves
higher
velocities
than
silver-blood.
Increasing
Biot
number
enhances
cooling
at
arterial
wall.
Detailed
graphs
3D
contour
plots
illustrate
effects
on
temperature,
velocity,
skin
friction,
Nusselt
number.
Medicina,
Journal Year:
2024,
Volume and Issue:
60(9), P. 1384 - 1384
Published: Aug. 24, 2024
Nanomedicine
is
a
newer,
promising
approach
to
promote
neuroprotection,
neuroregeneration,
and
modulation
of
the
blood–brain
barrier.
This
review
includes
integration
various
nanomaterials
in
neurological
disorders.
In
addition,
gelatin-based
hydrogels,
which
have
huge
potential
due
biocompatibility,
maintenance
porosity,
enhanced
neural
process
outgrowth,
are
reviewed.
Chemical
modification
these
especially
with
guanidine
moieties,
has
shown
improved
neuron
viability
underscores
tailored
biomaterial
design
applications.
further
discusses
strategies
modulate
barrier—a
factor
critically
associated
effective
delivery
drugs
central
nervous
system.
These
advances
bring
supportive
solutions
solving
conditions
innovative
therapies
for
their
treatment.
Nanomedicine,
as
applied
neuroscience,
presents
significant
leap
forward
new
therapeutic
that
might
help
raise
treatment
management
disorders
much
better
levels.
Our
aim
was
summarize
current
state-of-knowledge
this
field.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(17), P. 7718 - 7718
Published: Sept. 1, 2024
The
purpose
of
this
study
was
to
evaluate
the
properties
and
pharmacokinetics
liposomal
vitamin
C
in
powder
form
obtained
by
a
method
devoid
organic
solvents.
liposome
morphology
were
analyzed
using
scanning
electron
microscopy
(SEM)
cryogenic
transmission
(cryo-TEM),
respectively.
Additionally,
carrier
particle
size,
size
distribution
(STEP-Technology®;
L.U.M.
GmbH,
Berlin,
Germany),
zeta
potential
value
determined.
pharmacokinetic
parameters
non-liposomal
(AUC,
Cmax,
C10h,
C24h)
compared
randomized,
single-dose,
double-blind,
cross-over
trial
(ClinicalTrials.gov
ID:
NCT05843617)
involving
healthy
adult
volunteers
(n
=
10,
1000
mg
dose).
process
spray
drying
used
transform
liquid
suspensions
liposomes
into
did
not
adversely
affect
quality
particles
obtained.
Compared
non-encapsulated
C,
oral
administration
formulation
resulted
significantly
better
absorption
ascorbic
acid
bloodstream,
which
equated
higher
bioavailability
product
(30%
increase
AUC,
p
<
0.05).
duration
elevated
blood
levels
also
longer
(C24h
30%,
Although
results
are
promising
suggest
for
limited
sample
necessitates
further
research
with
larger
cohort
confirm
these
findings.
3 Biotech,
Journal Year:
2024,
Volume and Issue:
14(12)
Published: Nov. 28, 2024
Abstract
The
goal
of
the
research
was
to
develop
a
hydrophobic
octanoate
salt
chitosan
(CS–OA)
and
use
as
nanoparticle
platform
for
delivery
curcumin
(CUR)
into
prostate
cancer
cells.
nanoprecipitation
technique
used
prepare
nanoparticles,
which
were
measured
particle
size
encapsulation
efficacy
relative
CUR–CS
nanoparticles.
cytotoxicity
CUR–OA–CS
nanoparticles
evaluated
in
cancerous
cells
(PC3
DU145)
comparison
with
corresponding
blank
hydroalcoholic
CUR
solution.
PXRD,
SEM,
TEM
also
examine
CUR–CS–OA
average
diameters
268.90
±
3.77
nm
221.90
2.79
nm,
respectively,
efficiencies
61.37
1.70%
60.20
3.17%.
PXRD
SEM
suggested
amorphization
CS–OA
void
exhibited
concentration-dependent
antiproliferative
action,
attributed
cellular
uptake
CS.
loading
these
increased
their
even
more.
potential
special
system
additional
cytotoxic
drugs
different
malignant
can
be
further
explored.
