Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: June 17, 2024

Abstract Background Gangba sheep as a famous breed of Tibetan sheep, its wool color is mainly white and black. economically important high-quality raw material for blankets serge. However, relatively few studies have been conducted on the sheep. Results To fill this research gap, study an in-depth analysis two populations (black color) using whole genome resequencing to identify genetic variation associated with color. Utilizing PCA, Genetic Admixture, N-J Tree analyses, present revealed consistent relationship structure between black colored populations, which their history. Analysis selection signatures multiple methods (F ST , π ratio, Tajima's D), 370 candidate genes were screened in group (GBB vs GBW); among them, MC1R, MLPH, SPIRE2, RAB17, SMARCA4, IRF4, CAV1, USP7, TP53, MYO6, MITF, MC2R, TET2, NF1, JAK1, GABRR1 are melanin synthesis, delivery, distribution. The enrichment results identified 35 GO entries 19 KEGG pathways formation phenotype. 311 (GBW GBB); REST, POU2F1, ADCY10, CCNB1, EP300, BRD4, GLI3 SDHA interfering differentiation neural crest cells into melanocytes, affecting proliferation inhibiting synthesis. 31 22 Conclusions This provides information understanding mechanism Gangba, knowledge improving optimizing improvement selective breeding produce specific colors can meet demand diversity products textile market.

Language: Английский

Genomic insight into X chromosome dynamics in high altitude adaptation of trans-Himalayan yaks

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

This study delves into the genomic foundations of high-altitude adaptation in Indian yaks, with a specific emphasis on X chromosome and its role traits related to production, reproduction, immunity. Utilizing whole-genome resequencing, we identified 319,015 high-quality chromosomal SNPs from 30 unrelated yaks 8 Jinchuan yaks. These were analyzed through various statistical methodologies, including composite likelihood ratio (CLR) statistics, Tajima’s D, iHS, F_ST, XP-EHH. Our findings highlight several genes associated adaptation, such as AIFM1, APOOL, ATRX, CHST7, DACH2, DGAT2L6, DIAPH2, EIF2S3B, CLR approaches. Additionally, GPR119, HS6ST2, MAGED1, MOSPD1, PQBP1, SLC25A14, SLC35A2, TIMM17B, WDR44 exhibited common selection signatures across F_ST XP-EHH methods. Unique loci each yak population uncovered chromosome, which are critical for adaptability, immunity, production traits. Notably, our regions containing RLIM gene Himachali is crucial Dosage Compensation chromosome. research offers new insights X-linked different populations, enhancing understanding mechanisms underlying adaptation.

Language: Английский

Detecting Selection Signatures on the X Chromosome in the Brazilian Nelore Through Whole-Genome Sequencing

Published: Jan. 1, 2024

Language: Английский