Isolation, Characterization, Chemical Profiling and Evaluation of Antidiabetic and Antioxidant Potential of Innula cappa (Buch.-Ham. ex D. Don) DC Leaves in Alloxan-Induced Type 2 Diabetic Mice DOI Creative Commons
Shahid Rahman, Gul Jan,

Farzana Gul Jan

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(12)

Published: Dec. 1, 2024

Background Innula cappa (Buch.-Ham. ex D. Don) DC (Compositae) is used in folkloric medicine to treat diabetes and other ailments. The current study aimed assess the anti-hyperglycemic antioxidant effects of methanolic extract solvent fractions I. leaves as well bioassay guided isolation active compounds from extract. Method α-amylase α-glucosidase inhibition extracts was evaluated by colorimetric assays, anti-diabetic activity tested on alloxan-induced diabetic mice model. Moreover, flame emission atomic absorption spectrometry techniques were employed analyze chemical composition plant. Compounds identified isolated leaf latex using FTIR, GCMS, silica gel column chromatography, their structures determined 1 H-NMR, 13 C-NMR, ESI-MS spectral data. Results results showed that ME significant α-amylase, inhibitory hyperglycemic activities, significantly improving body weight, glucose tolerance, lipid profiles, hematological markers. UV-FTIR spectra revealed diagnostic peaks corresponding several functional groups whereas GC-MS analysis 35 phytochemical components with different retention times cappa. Spectroscopic led 5 including ursolic acid, benzoic 2-hydroxybenzoic stigmasterol β -sitosterol. Conclusion exert antihyperglycemic demonstrating medicinal value emphasize its significance unexplored natural reservoirs phytogenic chemicals require further investigation cutting-edge analytical techniques.

Language: Английский

Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant DOI Creative Commons
Yingshuai Wang, Lihua Shi, Jiachen Lu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 30, 2025

Language: Английский

Citations

1
Drying Kinetics of Deglet Enour Date Seeds, Antioxidant, Antibacterial, Antidiabetic and Bio-preservative Potencies DOI

Amal Dbeibia,

Ramla Khiari, Daoued Mihoubi

et al.

Waste and Biomass Valorization, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Rutin Isolated from Acalypha indica L.: A Comprehensive Analysis of Its Antibacterial and Anticancer Activities DOI

Sudhakar Chekuri,

Sanjeeva Reddy Sirigiripeta,

Sreenu Thupakula

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 765, P. 151833 - 151833

Published: April 16, 2025

Language: Английский

Citations

0
Utilizing HPLC-DAD, multivariate analysis, molecular docking, and in vitro validation methods to investigate phenolic compounds with potential antidiabetic properties in Fraxinus mandshurica DOI
Jianjin Guo, Chi‐Tang Ho, Naisheng Bai

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111771 - 111771

Published: Sept. 1, 2024

Language: Английский

Citations

1
Isolation, Characterization, Chemical Profiling and Evaluation of Antidiabetic and Antioxidant Potential of Innula cappa (Buch.-Ham. ex D. Don) DC Leaves in Alloxan-Induced Type 2 Diabetic Mice DOI Creative Commons
Shahid Rahman, Gul Jan,

Farzana Gul Jan

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(12)

Published: Dec. 1, 2024

Background Innula cappa (Buch.-Ham. ex D. Don) DC (Compositae) is used in folkloric medicine to treat diabetes and other ailments. The current study aimed assess the anti-hyperglycemic antioxidant effects of methanolic extract solvent fractions I. leaves as well bioassay guided isolation active compounds from extract. Method α-amylase α-glucosidase inhibition extracts was evaluated by colorimetric assays, anti-diabetic activity tested on alloxan-induced diabetic mice model. Moreover, flame emission atomic absorption spectrometry techniques were employed analyze chemical composition plant. Compounds identified isolated leaf latex using FTIR, GCMS, silica gel column chromatography, their structures determined 1 H-NMR, 13 C-NMR, ESI-MS spectral data. Results results showed that ME significant α-amylase, inhibitory hyperglycemic activities, significantly improving body weight, glucose tolerance, lipid profiles, hematological markers. UV-FTIR spectra revealed diagnostic peaks corresponding several functional groups whereas GC-MS analysis 35 phytochemical components with different retention times cappa. Spectroscopic led 5 including ursolic acid, benzoic 2-hydroxybenzoic stigmasterol β -sitosterol. Conclusion exert antihyperglycemic demonstrating medicinal value emphasize its significance unexplored natural reservoirs phytogenic chemicals require further investigation cutting-edge analytical techniques.

Language: Английский

Citations

0