Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review

Zeitschrift für Naturforschung C, Journal Year: 2024, Volume and Issue: 79(5-6), P. 107 - 124

Published: May 1, 2024

Chitosan (CT), a natural, cationic, chemically stable molecule, biocompatible, biodegradable, nontoxic, polysaccharide derived from the deacetylation of chitin, has very uniquely surfaced as material promise for drug delivery and biomedical applications. For oral, ocular, cutaneous, pulmonary, nose-to-brain routes, CT-coated nanoparticles (CTCNPs) have numerous advantages, consisting improved controlled release, physicochemical stability, cell tissue interactions, increased bioavailability efficacy active ingredient. CTCNPs broad range therapeutic properties including anticancer, antiviral, antifungal, anti-inflammatory, antibacterial properties, treating neurological disorders, other diseases. This led to substantial research into many potential uses CT vehicle. also been employed in wide processes, bone cartilage regeneration, ocular periodontal heart wound healing. Additionally, used cosmeceutical, bioimaging, immunization, gene transfer exhibits number biological activities, which are basis its remarkable use vehicle, these activities covered detail this article. The alterations applied obtain necessary described.

Language: Английский

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Structural characterization and immunomodulatory activity of an exopolysaccharide isolated from Bifidobacterium adolescentis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140747 - 140747

Published: Feb. 6, 2025

Language: Английский

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Advanced Optimization of Bioprocess Parameters for Exopolysaccharides Synthesis in Extremophiles

Processes, Journal Year: 2025, Volume and Issue: 13(3), P. 822 - 822

Published: March 11, 2025

Exopolysaccharides (EPSs) represent versatile biopolymers finding diverse applications in food, pharmaceuticals, and bioremediation industries. Extremophiles, thriving under extreme environmental conditions, have emerged as a promising source of novel EPSs with better stability bioactivity. The present work reviews the complex influence various abiotic factors bioprocess parameters such temperature, pH, carbon nitrogen sources, C/N ratios, oxygen transfer dynamics on production from extremophilic microorganisms. Results underline important role temperature for structural functional properties EPSs, synthesis cryoprotective polymers psychrophiles to thermostable thermophiles cold stress. pH has an extensive effect enzymatic activities: optimal neutral slightly acidic conditions exist most strains. Carbon sources determine not only yield but also its features, while ratios regulate balance between biomass polymer biosynthesis. Besides that, limitations—which may happen particularly viscous or saline media—are overtaken by optimized bioreactor configuration stirring strategies. These findings are highly relevant development tailored cultivation enabling maximization EPS yields adaptation comply industrial requirements. This study provides framework enhancing leveraging adaptive traits extremophiles. approach supports sustainable use biopolymers, advances fermentation processes, helps uncover underlying mechanisms involved.

Language: Английский

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From Gut to Glory: Unveiling the Microbiome’s Impact on Human Health

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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