Assessing metal-induced glycation in French fries DOI Creative Commons

Seth Nobert,

Haley Wolgien-Lowe,

Timothy J. Davis

et al.

Metallomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 30, 2024

Non-enzymatic glycation is the chemical reaction between amine group of an amino acid and carbonyl a reducing sugar. The final products this reaction, advanced end-products (AGEs), are known to play key role in aging many chronic diseases. kinetics AGE formation depends on several factors, including pH, temperature, presence prooxidant metals, such as iron copper. In study, effect copper rate outcome non-enzymatic was examined test tube food model, using chromatography spectrometry methods. Binding efficiencies chelating agents selected metals were also assessed. Phytic most efficient tested agents. phytic French fries evaluated. While treatment increased amounts UV-absorbing compounds fries, ingredient rich showed opposite effect. This study suggests that can affect rate, outcome, yield they do so differently when free or chelated. Moreover, despite being excellent chelator, promote fried potentially via mechanisms other than metal-induced glycation.

Language: Английский

An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement DOI Creative Commons
Chandrabhan Prajapati, Sachchida Nand, Santosh Kumar Singh

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical

Language: Английский

Citations

7
Copper Molybdate-Catalyzed Esterification of Levulinic Acid: A Heterogeneous Approach for Biofuel Synthesis DOI Open Access
A. Ribeiro, Wyvirlany V. Lobo,

Talles André Feitosa de Carvalho

et al.

Catalysts, Journal Year: 2025, Volume and Issue: 15(4), P. 357 - 357

Published: April 6, 2025

The catalytic esterification of levulinic acid (LA) to methyl levulinate (ML) was investigated using copper molybdate (Cu3(MoO4)2(OH)2) as a heterogeneous catalyst. catalyst, synthesized via chemical precipitation, exhibited monoclinic structure with self-assembled nanoplates forming spherical mesostructures. Structural characterization confirmed its high crystallinity, while textural analysis revealed BET surface area 70.55 m2 g−1 pore sizes in the nanometric range (1–6 nm). performance systematically evaluated under varying reaction conditions, including temperature, catalyst dosage, time, methanol-to-LA molar ratio, alcohol type, and reusability. Optimal conversion 99.3% achieved at 100 °C, 1:20 5% loading, time 4 h. Comparative other catalysts demonstrated superior efficiency stability Cu3(MoO4)2(OH)2, minimal activity loss over four reuse cycles (final 77.1%). Mechanistic insights suggest that is attributed Lewis Brønsted sites, facilitating efficient esterification. This study underscores potential sustainable recyclable for biofuel additive synthesis, advancing green chemistry strategies biomass valorization.

Language: Английский

Citations

1
Accumulation Characteristics of Natural Ophiocordyceps sinensis Metabolites Driven by Environmental Factors DOI Creative Commons

Tao Wang,

Chuyu Tang,

Jianbo Chen

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(8), P. 414 - 414

Published: July 27, 2024

The environment is an important factor affecting the composition and abundance of metabolites in

Language: Английский

Citations

4
Endophytic Fungi: A Treasure Trove of Antifungal Metabolites DOI Creative Commons
Sanjai Saxena, Laurent Dufossé, S. K. Deshmukh

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1903 - 1903

Published: Sept. 18, 2024

Emerging and reemerging fungal infections are very common in nosocomial non-nosocomial settings people having poor immunogenic profiles either due to hematopoietic stem cell transplants or using immunomodulators treat chronic inflammatory disease autoimmune disorders, undergoing cancer therapy suffering from an immune weakening like HIV. The refractory behavior of opportunistic fungi has necessitated the discovery unconventional antifungals. emergence black fungus infection during COVID-19 also triggered antifungal program. Natural products one alternative sources Endophytic reside co-evolve within their host plants and, therefore, offer a unique bioresource novel chemical scaffolds with array bioactivities. Hence, immense possibilities exist that these expressed by endophytic may play crucial role overcoming burgeoning antimicrobial resistance. These so comprise classes beginning cyclic peptides, sesquiterpenoids, phenols, anthraquinones, coumarins, etc. In this study, reported last six years (2018-2023) have been explored document entities they produce. Approximately 244 metabolites documented period different groups existing as endophytes. Various aspects metabolites, such potential structures, presented. Yet another aspect review is exploration volatile compounds produced fungi. Further strategies epigenetic modifications well biological methods OSMAC induce silent gene clusters presented generate unprecedented bioactive

Language: Английский

Citations

3
Health-promoting benefits of the wild mushroom Suillus mediterraneensis (Jacquet. & J. Blum) Redeuilh, collected from Algeria: Myco-chemical investigation and bioactive properties DOI
Mimoune Souna, Choukri Tefiani, Tarik Mohammed Chaouche

et al.

Journal of Food Measurement & Characterization, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

0
Antioxidant and antiinflammatory endophytic fungal compounds for chronic diseases DOI

Sanskriti Negi,

Neha Kapoor, Lokesh Gambhir

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 175 - 200

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring the Antimicrobial, Antioxidant and Extracellular Enzymatic Activities of Culturable Endophytic Fungi Isolated from the Leaves of Kirkia acuminata Oliv DOI Creative Commons
Sikheto Joe Kubayi, Raymond Tshepiso Makola,

Khumisho Dithebe

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 692 - 692

Published: March 19, 2025

Fungal endophytes of medicinal plants produce diverse secondary metabolites and extracellular enzymes with therapeutic biotechnological potential. However, the biological potential fungal from South African remain relatively underexplored. In this study, antimicrobial, antioxidant, anti-inflammatory enzymatic capabilities five previously isolated leaves Kirkia acuminata Oliv. were investigated. Sequencing internal transcribed spacer (ITS) regions revealed that isolates belonged to genera Setosphaeria, Diaporthe Corynespora. The broth micro-dilution assay Folin–Ciocalteau reagent method used assess antibacterial activity total phenolic content (TPC) endophytes’ ethyl acetate crude extracts (CEs), respectively. antioxidant was assessed using ferric reducing power (FRAP) 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. influence CE Setosphaeria rostrata KaL-4 on viability LPS-induced interleukin-6 (IL-6) production in Raw 264.7 macrophages a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) an ELISA, ability proteases, laccases peroxidases also determined. CEs displayed antimicrobial MICs ranging 0.63 1.25 mg/mL 40% 18% 60% 48%, S. possessed highest TPC demonstrated dose-dependent cytotoxicity. further significant reduction IL-6 at concentration 0.75 µg/mL. Only one isolate proteases index (EI) 0.66, while (EI range 0.14 1.15) produced by all isolates. These findings suggest are promising sources bioactive compounds industry-significant enzymes.

Language: Английский

Citations

0
Comprehensive Phytochemical, Antioxidant, and Antibacterial Analysis of Vitex agnus-castus L. Essential Oil (VACEO): Insights from ADMET and Molecular Docking Studies DOI Creative Commons
Dounia Azzouni, Soukaina Alaoui Mrani,

Fadoua Bahij

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 462 - 462

Published: March 25, 2025

Background/Objectives: The phytochemical composition, antioxidant, and antibacterial properties of Vitex agnus-castus L. essential oil (VACEO), extracted from fruit harvested in the Middle Atlas region Morocco, were investigated. Methods/Results: A full chemical analysis VACEO was performed to identify principal components using GC–MS, demonstrating that caryophyllene (13.87%), 1-(4-Isopropylphenyl)-2-methylpropyl acetate (12.20%), τ-Cadinol (5.41%) most important constituents this oil. In addition, antioxidant activity evaluated DPPH, FRAP, TAC, beta-carotene bleach tests; demonstrated an IC50 0.93 ± 0.03 mg/mL (DPPH), EC50 0.146 0.004 (FRAP), a total capacity 0.794 0.02 mg BHT equivalent/g EO, with relative at 72.69 0.3%. Antibacterial assays revealed inhibition diameters ranging 13.25 1.00 mm 21.11 0.25 mm, minimum inhibitory concentrations (MICs) 0.02–0.04 against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa. Moreover, ADMET suggested potential for drug development, specific insights into pharmacokinetics, safety, molecular docking, clarifying its interactions key bacterial proteins. Conclusions: These results confirm promising therapeutic pharmaceutical through bioactive compounds.

Language: Английский

Citations

0
Fungal Endophytes: A Resource for Producing Extracellular Enzymes DOI

Abhishek Sahoo,

Indurekha Meher,

Sushree Pralipta Chhotaray

et al.

Microorganisms for sustainability, Journal Year: 2025, Volume and Issue: unknown, P. 105 - 145

Published: Jan. 1, 2025

Language: Английский

Citations

0
Role of grass endophytic fungi as a natural resource of bioactive metabolites DOI

R. Nischitha

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(10)

Published: Sept. 26, 2024

Language: Английский

Citations

1