Dual-functional Quercus palustris leaves extract as a sustainable corrosion inhibitor for low-carbon steel and its biomedical potential: Electrochemical, biological, and computational insights

Sustainable materials and technologies, Journal Year: 2025, Volume and Issue: unknown, P. e01378 - e01378

Published: March 1, 2025

Language: Английский

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In‐Vitro Antimicrobial, Antidiabetic and Anticancer Activities of Calyptocarpus Vialis Extract and its Integration with Computational Studies

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 12, 2024

Abstract Calyptocarpus vialis ( C. ), a plant of Asteraceae family exhibits nutritional value, antioxidant properties and has potential for various other biomedical applications. The present study is focused to assess the antimicrobial, antidiabetic, anticancer extract its integration with computational studies. antimicrobial activity performed against Staphylococcus aureus S. Bacillus subtilis B. ) pseudomonas aeruginosa P. , Escherichia coli E. bacteria Saccharomyces cerevisiae Candida albicans fungi using disc diffusion method. Maximum Zone Inhibition (ZOI) 37±3.2 35±2.9 mm obtained respectively, whereas ZOI 39±2.8 at dose 500 μg/mL. shows strong α‐amylase inhibition IC 50 ~46.8±0.81 μg/mL inferring about antidiabetic potential. Anticancer checked HCT‐116 DU‐145 cell lines 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium‐bromide (MTT) assay, which excellent value 38.09±0.65 μg/ml 36.34±1.05 respectively. results are further verified studies considering interaction among phytochemicals selected targets. Extract found potent biological activities promising candidate development new drugs.

Language: Английский

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Identification of Potential Anticancer Phytochemicals of Piper chaba by Comprehensive Molecular Docking, Molecular Dynamics Simulation and In‐Vitro Studies

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

ABSTRACT Human colon cancer and prostate are the most common malignancy globally. Despite availability of many treatments, resistance to traditional medicines, such as chemotherapy radiotherapy, remains a severe obstacle in treatment. Hence, searching for new therapeutic options is utmost priority. The present investigation evaluates in‐silico in‐vitro anticancer potential phytochemicals Piper chaba . cytotoxicity results demonstrated that plant extract exhibited significant activity, with IC 50 values 12.66 ± 0.25 µg/mL HCT‐116 19.49 0.37 DU‐145. Molecular docking molecular dynamics simulations were performed explore interaction drug targets phytochemicals. Subsequently, pharmacokinetic parameters calculations evaluate drug‐likeness. Piperine exhibits highest binding affinity vascular endothelial growth factor receptor‐2 (VEGFR2) protein score −9.71 kcal/mol. Sylvatine had greater human epidermal receptor 3 (HER3) than other Isopiperine, chabamide, Piperlonguminine, Santamarine Versalide only ligand activity IKK beta (inhibitor kappa B kinase). Additionally, principal component analysis was strengthen investigation's scope. These proposed reported possess VEGFR2, HER2 inhibition. best phytochemical hits have excellent hold massive potential, opening up avenues prospective future investigations

Language: Английский

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Green Synthesis of AgFe Bimetallic Nanoparticles from Calyptocarpus vialis Plant Extract for Enhanced Catalytic Reduction of 4-NP, Antioxidant and Antibacterial Activities

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116829 - 116829

Published: April 1, 2025

Language: Английский

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Therapeutic potential of Glycyrrhiza glabra L. extract and atorvastatin in HFD-induced MAFLD: in vitro and in vivo exploration

3 Biotech, Journal Year: 2025, Volume and Issue: 15(6)

Published: May 6, 2025

Language: Английский

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Green Synthesis of Copper Oxide Nanoparticles from Waste Solar Panels Using Piper nigrum Fruit Extract and Their Antibacterial Activity

Catalysts, Journal Year: 2024, Volume and Issue: 14(8), P. 472 - 472

Published: July 24, 2024

To promote environmental development and sustain resource circularity, recycling metals from electronic waste is essential. Electronic a significant secondary source of metals, with its production increasing rapidly most remaining unrecycled. In solar panels, copper the second-most-valuable metal after silver. We propose an innovative method to recycle panels convert it into oxide nanoparticles (CuONPs) using green synthesis method. Synthesizing CuONPs advantageous due their large surface area compared bulk material. Nitric acid, strong oxidizing agent, was used leach solid wires in panels. A method, following bottom-up approach, employed Piper nigrum fruit extract synthesize CuONPs. The synthesized were characterized various qualitative quantitative techniques. Spectroscopic analysis confirmed formation CuONPs, transmission electron microscopy revealed that spherical sizes up 60 nm. Biomolecules detected on crystalline These exhibited antibacterial activity against Gram-negative Escherichia coli Gram-positive Staphylococcus aureus well-diffusion showing larger zone inhibition for E. S. aureus. This research demonstrates complete recovery conversion useful which have potential medicinal applications.

Language: Английский

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Rheological and Anticorrosion Study of Piper chaba Extract and Coating for Mild Steel in 2M H2SO4

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135989 - 135989

Published: Dec. 1, 2024

Language: Английский

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Isolation, Structure Elucidation, and Bioactivity Evaluation of Two Alkaloids From Piper chaba H. Stem: A Traditional Medicinal Spice and Its Chemico‐Pharmacological Aspects

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(12), P. 10680 - 10698

Published: Nov. 22, 2024

ABSTRACT Bangladesh is endowed with an abundance of excellent medicinal plant resources. A well‐known traditional Piper chaba H. from the Piperaceae family rich in bioactive phytochemicals that have antidiarrheal, antimicrobial, analgesic, antioxidant, anticancer, and cytotoxic effects. This locally known as “Chuijhal,” stem used spices. In current research program, stems P. were selected its chemical biological investigations such analgesic effects performed. Moreover, docking models accomplished by exploiting PyRx‐Virtual Screening software implied isolated compounds exert different pharmacological activity inhibiting their targeted receptors. Phytochemical revealed isolation Chingchengenamide A, a relatively rare alkaloid . Another Chabamide I which piperine dimer was also isolated. Their structures confirmed comparing these compounds' spectral data ( 1 H 13 C NMR) previously published data. Antidiarrheal shows percent reduction diarrhea 46.67% 40%, respectively, for (at 20 mg/kg b.w.) compared 80% standard loperamide. Similarly, writhing 53.06% 42.86%, at similar doses diclofenac sodium considered standard. Both alkaloids showed auspicious outcomes against test microorganisms during disk diffusion antimicrobial assay. Molecular ADME/T analysis validate potent basis utilization treating diarrhea, pain, microbial infection. These results emphasize need to investigate potential source natural therapies common health issues, laying foundation future research.

Language: Английский

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Radical-Mediated Photocatalytic Dye Degradation and Antimicrobial Properties of La2NiMnO6 Nanoparticles

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 49(3), P. 807 - 824

Published: Dec. 6, 2024

This work focused on engineering double perovskite (DP) La 2 NiMnO 6 (LNMO) nanoparticles (NPs) through the co-precipitation method and further calcined at 1000 °C.

Language: Английский

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