Unlocking the potential of gold nanoparticles as a game-changer in the fight against hepatocellular carcinoma
Exploration of Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
According
to
research,
hepatocellular
carcinoma
(HCC),
ranks
third
globally
in
terms
of
cause
death
and
is
the
fifth
most
common
type
cancer
overall.
Finding
novel
means
diagnosis
treatment
therefore
crucial.
The
use
nanotechnology
as
a
has
drawn
lot
interest
recently.
Despite
significant
advancements
detection
treatment,
there
still
long
way
go
before
this
disease
completely
eradicated.
Therefore,
it’s
critical
find
innovative
ways
diagnose
cure
conditions.
In
particular,
substantial
inertness
metallic
nanoparticles
(NPs)
their
nanoscale
structures,
which
have
sizes
comparable
many
biological
molecules,
attract
great
deal
biomedical
field.
Due
exceptional
optical
qualities,
chemically
modified
surface
through
attachment
various
ligands,
biocompatibility
(bio-inertness
low
cytotoxicity),
superior
properties,
gold
NPs
(AuNPs)
garnered
interest.
current
review
discusses
efficiency
AuNPs
fields,
including
imaging,
immunotherapy,
photothermal
therapy
for
treating
liver
cancer.
Finally,
summarized
limitations
prospects
AuNPs.
Language: Английский
Bacterial synthesis of anisotropic gold nanoparticles
Applied Microbiology and Biotechnology,
Journal Year:
2025,
Volume and Issue:
109(1)
Published: March 10, 2025
Abstract
Pseudomonas
aeruginosa
was
used
to
synthesize
anisotropic
gold
nanoparticles
from
the
unusually
reducible
aryldiazonium
(III)
salt
of
chemical
formula
[HOOC-4-C
6
H
4
N≡N]AuCl
(abbreviated
as
DS-AuCl
).
We
investigated
effect
bacterial
cell
density,
temperature,
and
pH
on
AuNP
synthesis.
The
density
6.0
×
10
8
CFU/mL
successfully
reduced
0.5
mM
AuNPs
after
incubation
at
37
°C
(24
h),
42
25
(48
h).
Transmission
electron
microscopy
(TEM)
images
revealed
formation
spherical,
triangle,
star,
hexagon,
truncated
triangular
morphologies
for
synthesized
using
P.
bacteria.
average
size
h)
39.0
±
9.1
nm,
26.0
8.1
36.7
7.7
respectively.
3.7,
7.0,
12.7
14.7
3.8
7.3
2.5
respectively,
with
decreasing
a
12.7.
reduction
confirmed
X-ray
photoelectron
spectroscopy
(XPS).
significant
peaks
C1s,
Au4f
doublet,
N1s,
O1s
are
centered
285,
84–88,
400,
532
eV.
ability
inactivated
bacteria
(autoclave-dead
mechanically
lysed
bacteria),
peptidoglycan,
lipopolysaccharides
reduce
also
investigated.
Anisotropic
were
peptidoglycan
but
not
lipopolysaccharides.
demonstrated
biocompatibility
human
RBCs
safe,
no
antibacterial
activities
against
Escherichia
coli
Staphylococcus
aureus
.
This
is
first
report
demonstrating
synthesis
gold(III)
salts
These
promising
candidates
exploring
potential
applications
in
nanomedicine
drug
delivery.
Key
points
•
Dead
residues
AuNPs.
hemocompatible.
Graphical
Language: Английский
Golden insights for exploring cancer: delivery, from genes to the human body using bimetallic Au/Ag nanostructures
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: May 25, 2025
Sweeping
contact
with
cancer
continues
to
rise
globally,
which
has
led
advanced
research
on
new
treatment
approaches;
nanotechnology
become
crucial
targeted
therapy.
Within
the
intimate
of
nanomaterials,
Au/Ag
nanostructures
have
emerged
as
highly
attractive
because
their
distinctive
desirable
characteristics
and
prospective
roles
in
diagnosis
well
The
developed
revealed
remarkable
biocompatibility,
optically
recursive
alteration,
magnificently
improved
therapeutic
effects
gold
silver
conjunction
each
other.
This
review
addresses
molecular
systemic
aspects
research,
including
impact
genetic
pathways
use
administration
human
organism.
We
explain
some
related
mechanisms
action,
such
photothermal
therapy
(PTT),
photodynamic
(PDT),
drug
delivery
systems
where
they
display
potential
benefits
towards
offering
a
more
approach
fewer
side
effects.
latest
development
shown
that
prospect
real-time
imaging
biomarker
identification,
owing
this
are
being
viewed
tool
for
individualized
treatment.
However,
there
still
limitations:
challenges
scaling
up,
biological
safety,
bringing
it
clinic.
It
is
therefore
incumbent
upon
these
managements
overcome
hurdles
optimize
impact.
As
result,
current
findings
briefly
reviewed,
directions
discussed
support
revolutionary
role
Language: Английский