Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review

Plants, Journal Year: 2025, Volume and Issue: 14(5), P. 827 - 827

Published: March 6, 2025

Cruciferae family vegetables are remarkably high in phytochemicals such as Indole-3-carbinol (I3C) and Diindolylmethane (DIM), which widely known nutritional supplements. I3C DIM have been studied extensively different types of cancers like breast, prostate, endometrial, colorectal, gallbladder, hepatic, cervical, well other tissues. In this review, we summarized the protective effects against cardiovascular, neurological, reproductive, metabolic, bone, respiratory, liver, immune diseases, infections, drug- radiation-induced toxicities. Experimental evidence suggests that offer protection due to their antioxidant, anti-inflammatory, antiapoptotic, immunomodulatory, xenobiotic properties. Apart from beneficial effects, present review also discusses possible toxicities reported various preclinical investigations. So far, most reports about diseases only studies; emphasizes dire need for large-scale clinical trials on these human diseases. Further, in-depth research is required improve bioavailability two achieve desirable effects. Overall, our may become potential drug candidates combating dreadful

Language: Английский

Neuroprotective effects of Indole 3-carbinol against Scopolamine-Induced cognitive and memory impairment in rats: modulation of oxidative stress, inflammatory and cholinergic pathways

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(4)

Published: March 18, 2025

Language: Английский