Nanosome‐Mediated Delivery Of Hdac Inhibitors and Oxygen Molecules for the Transcriptional Reactivation of Latent Hiv‐Infected Cd4+ T Cells DOI
Joohye Hong,

Yonghyun Choi,

Gahyun Lee

et al.

Small, Journal Year: 2023, Volume and Issue: 19(37)

Published: April 28, 2023

The treatment of human immunodeficiency virus (HIV) infection is notoriously difficult due to the ability this remain latent in host's CD4+ T cells. Histone deacetylases (HDACs) interfere with DNA transcription HIV-infected hosts, resulting viral latency. Therefore, HDAC inhibitors can be used activate latently infected cells, after which eliminated through a shock-and-kill strategy. Here, drug delivery system developed effectively deliver Given that efficacy reduced under hypoxic conditions, oxygen-containing nanosomes are as carriers. Oxygen-containing improve efficiency chemotherapy by delivering essential oxygen Additionally, their phospholipid bilayer structure makes them uniquely well-suited for delivery. In study, novel taking advantage carriers these nanosomes, incorporating multi-drug strategy consisting and PKA activators, introducing CXCR4 binding peptides specifically target Oxygen enhanced targeting capability introduction peptide mitigate toxicity slow down release. observed changes expression p24, capsid protein HIV, indirectly confirm proposed induce transcriptional reactivation HIV

Language: Английский

Adrinogenic Colon Cancer Treatment Using Poly (β-Amino Esters) (PBAEs): Mechanistic Insights, Advanced Utilization Approaches, and Future Directions DOI

Shridhar Thorat,

Sankha Bhattacharya

Journal of Macromolecular Science Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 27, 2025

Language: Английский

Citations

0
CircRNA-Based AntimiR Therapy: A Novel Approach to Hypertension Treatment DOI Creative Commons
Vahideh Tarhriz, Kamran Hosseini, Leila Abkhooie

et al.

Non-coding RNA Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Phytogenic fabrication of iron oxide nanoparticles and evaluation of their in vitro antibacterial and cytotoxic activity DOI Creative Commons
Sheik Aliya, Muruganantham Rethinasabapathy,

Jingon Yoo

et al.

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(6), P. 104703 - 104703

Published: Feb. 23, 2023

Several metal-based nanoparticles (NPs) have been found to be toxic and are known exert adverse health outcomes with irreversible side effects. This highlights the need discover effective, stable, biocompatible therapeutic components using natural sources. Here, a hexane extract of Nigella sativa seeds was used synthesize iron oxide NPs (NS-IONPs) embedded N. phytoconstituents. The acted as reducing agent that restricted size NS-IONPs 5–6 nm, signifying potential cleared through renal system. fabricated had prominent effect on pathogenic gram-negative bacteria, E. coli (19.3 mm) Salmonella typhi (14.2 lung cancer cells (lowest IC50 18.75 µg/mL) mainly by binding phospholipid cell membrane. resulted in shrinkage further inhibited growth. Transmission electron microscopy analyses revealed mechanisms cellular NP uptake varied depending type. Accumulation inside increased BAX expression arrested at G0/G1 phase, thereby conspicuously extending G0 phase initiate necrosis. Thus, these finding suggest synthesized exhibited high antibacterial activity effective cytotoxicity against lines A549 HCT116 compared IONPs. innovation current study is biogenic fabrication IONPs simple cost results stable nanomaterial, anticancer activity, which can explored furthermore for various biomedical applications.

Language: Английский

Citations

9
Polymeric nanotherapeutics: An emerging therapeutic approach for the management of neurodegenerative disorders DOI
Pratik Chakraborty, Chiranjib Bhattacharyya, Ranabir Sahu

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 91, P. 105267 - 105267

Published: Dec. 16, 2023

Language: Английский

Citations

9
Nanosome‐Mediated Delivery Of Hdac Inhibitors and Oxygen Molecules for the Transcriptional Reactivation of Latent Hiv‐Infected Cd4+ T Cells DOI
Joohye Hong,

Yonghyun Choi,

Gahyun Lee

et al.

Small, Journal Year: 2023, Volume and Issue: 19(37)

Published: April 28, 2023

The treatment of human immunodeficiency virus (HIV) infection is notoriously difficult due to the ability this remain latent in host's CD4+ T cells. Histone deacetylases (HDACs) interfere with DNA transcription HIV-infected hosts, resulting viral latency. Therefore, HDAC inhibitors can be used activate latently infected cells, after which eliminated through a shock-and-kill strategy. Here, drug delivery system developed effectively deliver Given that efficacy reduced under hypoxic conditions, oxygen-containing nanosomes are as carriers. Oxygen-containing improve efficiency chemotherapy by delivering essential oxygen Additionally, their phospholipid bilayer structure makes them uniquely well-suited for delivery. In study, novel taking advantage carriers these nanosomes, incorporating multi-drug strategy consisting and PKA activators, introducing CXCR4 binding peptides specifically target Oxygen enhanced targeting capability introduction peptide mitigate toxicity slow down release. observed changes expression p24, capsid protein HIV, indirectly confirm proposed induce transcriptional reactivation HIV

Language: Английский

Citations

8