Integration of nanobiosensors into organ-on-chip systems for monitoring viral infections DOI Creative Commons
Jiande Zhang, Minhyeok Kim, Seulgi Lee

et al.

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: Nov. 26, 2024

Abstract The integration of nanobiosensors into organ-on-chip (OoC) models offers a promising advancement in the study viral infections and therapeutic development. Conventional research methods for studying infection, such as two-dimensional cell cultures animal models, face challenges replicating complex dynamic nature human tissues. In contrast, OoC systems provide more accurate, physiologically relevant investigating infections, disease mechanisms, host responses. Nanobiosensors, with their miniaturized designs enhanced sensitivity, enable real-time, continuous, situ monitoring key biomarkers, cytokines proteins within these systems. This review highlights need integrating to advance virological improve outcomes. Although there is extensive literature on biosensors infection detection real OoCs continuous remains unachieved. We discuss advantages nanobiosensor real-time tracking critical biomarkers biosensor technologies, current studies. Additionally, we address main technical propose solutions successful integration. aims guide development biosensor-integrated OoCs, paving way precise diagnostics personalized treatments research. Graphical

Language: Английский

Advances and Challenges in 3D Modelling of Organ-on-a-Chip Devices with a Focus on the Glomerular Basement Membrane (GBM) and Tubular Systems: A Critical Review DOI
Jumanah Bahig,

Ahmed Shoker,

Huu Doan

et al.

BioChip Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD DOI Open Access

Yeo Min Yoon,

Sang‐Mi Woo,

Hwanuk Guim

et al.

BioFactors, Journal Year: 2025, Volume and Issue: 51(2)

Published: March 1, 2025

Calciprotein particles (CPPs) are blood-borne circulating nanoparticles composed of calcium phosphate and proteins that known to exacerbate pathological processes such as chronic kidney disease-mineral bone disorder (CKD-MBD). Despite the significant interest in CKD-MBD pathogenesis, research directly addressing CPP-induced fibrosis renal proximal tubules is rare, largely owing lack suitable vitro tissue models. Our study confirmed 3D-cultured tubule epithelial cells (PTECs) exhibited enhanced characteristics compared 2D-cultured PTECs when treated with CPPs, a key factor CKD-MBD, uremic toxin. under CKD-inducing conditions by CPPs were associated epithelial-mesenchymal transition (EMT), mediated transforming growth factor-β1 (TGF-β1), notable changes early EMT marker expression. Furthermore, this was attributed increased expression calcium-sensing receptor (CASR), for activation downstream cell division control protein 42 (CDC42), leading progression. This underscores potential PTEC-on-a-chip systems serve drug testing models, given heightened sensitivity these external environments. approach provides better understanding features CKD could contribute development more effective models therapeutics.

Language: Английский

Citations

0
Integration of nanobiosensors into organ-on-chip systems for monitoring viral infections DOI Creative Commons
Jiande Zhang, Minhyeok Kim, Seulgi Lee

et al.

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: Nov. 26, 2024

Abstract The integration of nanobiosensors into organ-on-chip (OoC) models offers a promising advancement in the study viral infections and therapeutic development. Conventional research methods for studying infection, such as two-dimensional cell cultures animal models, face challenges replicating complex dynamic nature human tissues. In contrast, OoC systems provide more accurate, physiologically relevant investigating infections, disease mechanisms, host responses. Nanobiosensors, with their miniaturized designs enhanced sensitivity, enable real-time, continuous, situ monitoring key biomarkers, cytokines proteins within these systems. This review highlights need integrating to advance virological improve outcomes. Although there is extensive literature on biosensors infection detection real OoCs continuous remains unachieved. We discuss advantages nanobiosensor real-time tracking critical biomarkers biosensor technologies, current studies. Additionally, we address main technical propose solutions successful integration. aims guide development biosensor-integrated OoCs, paving way precise diagnostics personalized treatments research. Graphical

Language: Английский

Citations

2