Identification and Characterization of the RNA Modifying Factors PUS7 and WTAP as Key Components for the Control of Tumor Biological Processes in Renal Cell Carcinomas DOI Creative Commons
Tim Hohmann, Urszula Grabiec,

Faramarz Dehghani

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 266 - 266

Published: April 9, 2025

Current research discusses the putative importance of RNA modification in tumor diseases. These modifications include predominantly pseudouridinylation, ortho-methylations on ribose residues, as well methylations organic bases. Such chemical directly influence fundamental properties such transcript stability, alternative splicing, and translation efficiency, all which are basic requirements for (tumor) cell proliferation, metabolism, migration, apoptosis resistance, etc. In this comparative study, two RNA-modifying factors, pseudouridine synthase 7 (PUS7, pseudouridinylation) WT1-associated protein (WTAP, m6A methylation), were identified using data from human renal carcinoma (RCC) tumors. PUS7 WTAP showed a statistically significant correlation with relevant proliferation prognosis markers CXCR4, TP53, PTEN, NRAS, immune checkpoints HLA-G LGALS9 associated effect overall survival. Furthermore, analyses also further target mRNAs biology WTAP. particular, components direct relevance mitosis, cycle, division, WNT pathway, identified.

Language: Английский

Identification and Characterization of the RNA Modifying Factors PUS7 and WTAP as Key Components for the Control of Tumor Biological Processes in Renal Cell Carcinomas DOI Creative Commons
Tim Hohmann, Urszula Grabiec,

Faramarz Dehghani

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 266 - 266

Published: April 9, 2025

Current research discusses the putative importance of RNA modification in tumor diseases. These modifications include predominantly pseudouridinylation, ortho-methylations on ribose residues, as well methylations organic bases. Such chemical directly influence fundamental properties such transcript stability, alternative splicing, and translation efficiency, all which are basic requirements for (tumor) cell proliferation, metabolism, migration, apoptosis resistance, etc. In this comparative study, two RNA-modifying factors, pseudouridine synthase 7 (PUS7, pseudouridinylation) WT1-associated protein (WTAP, m6A methylation), were identified using data from human renal carcinoma (RCC) tumors. PUS7 WTAP showed a statistically significant correlation with relevant proliferation prognosis markers CXCR4, TP53, PTEN, NRAS, immune checkpoints HLA-G LGALS9 associated effect overall survival. Furthermore, analyses also further target mRNAs biology WTAP. particular, components direct relevance mitosis, cycle, division, WNT pathway, identified.

Language: Английский

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