Battle of the Biomarkers of Systemic Inflammation DOI Creative Commons
Emilia Stec‐Martyna,

Karolina Wojtczak,

Dariusz Nowak

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 438 - 438

Published: April 18, 2025

Systemic inflammation is monitored with various biomarkers; of these, C-reactive protein (CRP) widely used due to its cost effectiveness and widespread implementation. However, lack specificity delayed kinetics have directed interest in cell-free DNA (cfDNA), which offers rapid responses cellular damage. Our review compares the use CRP cfDNA myocardial infarction, sepsis, physical exercise, focusing on their origins, kinetics, clinical utility. release from apoptotic or damaged cells increases within minutes hours, providing an early marker stress. In peaks early, indicating acute injury, while rises later, reflecting prolonged inflammation. correlates strongly disease severity prognosis, outperforming diagnosis. During immediate picture stress, whereas CRP’s response limits utility this context. The interaction between suggests combined application could improve diagnostic accuracy prognostic assessments. As testing becomes more available, researchers will need develop standardized protocols determine how it can best complement measurements practice. This approach promise for improving management systemic across diverse medical conditions.

Language: Английский

Immunoredox model for interpretation and prediction of human diseases DOI
Young Jun Kim, Hyungdon Lee,

Sofian Abdul-Nasir

et al.

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

Citations

0
Battle of the Biomarkers of Systemic Inflammation DOI Creative Commons
Emilia Stec‐Martyna,

Karolina Wojtczak,

Dariusz Nowak

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 438 - 438

Published: April 18, 2025

Systemic inflammation is monitored with various biomarkers; of these, C-reactive protein (CRP) widely used due to its cost effectiveness and widespread implementation. However, lack specificity delayed kinetics have directed interest in cell-free DNA (cfDNA), which offers rapid responses cellular damage. Our review compares the use CRP cfDNA myocardial infarction, sepsis, physical exercise, focusing on their origins, kinetics, clinical utility. release from apoptotic or damaged cells increases within minutes hours, providing an early marker stress. In peaks early, indicating acute injury, while rises later, reflecting prolonged inflammation. correlates strongly disease severity prognosis, outperforming diagnosis. During immediate picture stress, whereas CRP’s response limits utility this context. The interaction between suggests combined application could improve diagnostic accuracy prognostic assessments. As testing becomes more available, researchers will need develop standardized protocols determine how it can best complement measurements practice. This approach promise for improving management systemic across diverse medical conditions.

Language: Английский

Citations

0