Hydrogen Peroxide Vapor Disinfection in Liver Transplantation: Effects on Multidrug-Resistant Organism Colonization and Recipient Outcomes DOI Creative Commons
Fábio Silveira, Fábio Porto Silveira, Cassia Regina Sbrissia Silveira

et al.

Brazilian Journal of Transplantation, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 2, 2024

Introduction: The escalation of multidrug-resistant organism (MDRO) infections post-liver transplantation (LT) poses significant risks, with MDRO colonization amplifying infection susceptibility. Environmental disinfection is crucial in curbing healthcare-associated (HAI). Hydrogen peroxide vapor (HPV ) technology offers promise, yet its impact on and patient outcomes remains unclear. Methods: A cohort study enrolled 58 deceased adult LT recipients, comparing before after routine HPV implementation. followed terminal cleaning surgical rooms intensive care unit (ICU) boxes. Pathogen data included pre-transplant post-discharge colonization. Clinical covered recipient characteristics, disease severity, donor-recipient relationships. Statistical analyses assessed associations outcomes. Results: Twenty-seven patients were the before-HPV group, 24 after-HPV group. Demographic clinical characteristics comparable between groups. implementation significantly increased likelihood negative control swabs (odds ratio 2.33). Klebsiella pneumoniae carbapenemase was most frequent pathogen, site being primary site. Patients had shorter hospital stays (mean difference 10.54 days), notably diverging around 8th day hospitalization. HAI frequency 90-day mortality lower swabs. Conclusion: effectively reduced recipients. Negative correlated frequency, impacting positively. Despite challenges implementation, efficacy reducing suggests a valuable tool strategies for vulnerable populations like

Language: Английский

Antimicrobial mechanism study of NIR-Activated Chitosan-Montmorillonite Hydrogel and their anti-MDR S. aureus properties in vitro pig skin model DOI
Xinxin Liu,

Zhu Hong,

Rongrong Li

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106839 - 106839

Published: March 1, 2025

Language: Английский

Citations

0
Early Bacterial Pathogen Distribution and Risk Factors for Infections after Liver Transplantation: Retrospective Cohort Study DOI Creative Commons
Jingjie Guo,

Zhaojie Su,

Jianfa Zhong

et al.

International Journal of Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 107907 - 107907

Published: April 1, 2025

To provide a comprehensive analysis of the epidemiological characteristics and clinical features pathogens explore risk factors for post-liver transplant (LT) bacterial infections. A retrospective was conducted at Xiang'an Hospital Xiamen University First Affiliated Zhengzhou between 2021 2024. Binary logistic regression performed to identify independent factors, including genetic polymorphisms related infections within first month after LT. Two hundred forty-two liver donors recipients were included. Klebsiella pneumoniae (19.0%) most common gram-negative bacterium, whereas Staphylococcus aureus (7.1%) predominant gram-positive pathogen. respiratory tract infection infection. revealed that recipient SLCO1B1 rs4149015 AA genotype, preoperative hypertension, low red blood cell count post-LT in recipients. Our manifestations as well their polymorphisms. These findings valuable insights into early detection prevention infections, revealing potential avenues development methods prevent such therefore improve patient prognosis

Language: Английский

Citations

0
Desinfecção por Vapor de Peróxido de Hidrogênio no Transplante de Fígado: Efeitos na Colonização de Organismos Multirresistentes e nos Resultados do Receptor DOI Creative Commons
Fábio Silveira, Fábio Porto Silveira, Cassia Regina Sbrissia Silveira

et al.

Brazilian Journal of Transplantation, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 2, 2024

Introdução: A escalada das infecções por organismos multirresistentes (MR) pós-transplante de fígado (TF) representa riscos significativos, com a colonização MR amplificando suscetibilidade à infecção. desinfecção ambiental é crucial para conter as associadas assistência saúde (IRAS). tecnologia vapor peróxido hidrogênio (VPH) oferece promessas, mas seu impacto nas e nos resultados dos pacientes ainda não está claro. Métodos: Um estudo coorte incluiu 58 receptores TF adultos, comparando os antes depois da implementação rotineira do VPH. VPH seguiu limpeza terminal em salas cirúrgicas boxes unidade terapia intensiva. Os dados patógenos incluíram no pré- pós-transplante. clínicos abrangeram características receptores, gravidade doença binômio doador-receptor. As análises estatísticas avaliaram associações resultados. Resultados: Vinte sete estavam grupo 24 após o demográficas clínicas foram comparáveis entre grupos. aumentou significativamente probabilidade negativos swabs controle (razão chances 2,33). Klebsiella pneumoniae carbapenemase foi patógeno mais frequente, sítio cirúrgico sendo local primário comum. Pacientes tiveram internações hospitalares curtas (diferença média 10,54 dias), divergindo notadamente volta 8o dia internação. frequência IRAS mortalidade 90 dias menores negativos. Conclusão: reduziu efetivamente TF. Swabs se correlacionaram menor IRAS, impactando positivamente dias. Apesar desafios na VPH, sua eficácia redução sugere uma ferramenta valiosa estratégias populações vulneráveis como

Citations

0
Hydrogen Peroxide Vapor Disinfection in Liver Transplantation: Effects on Multidrug-Resistant Organism Colonization and Recipient Outcomes DOI Creative Commons
Fábio Silveira, Fábio Porto Silveira, Cassia Regina Sbrissia Silveira

et al.

Brazilian Journal of Transplantation, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 2, 2024

Introduction: The escalation of multidrug-resistant organism (MDRO) infections post-liver transplantation (LT) poses significant risks, with MDRO colonization amplifying infection susceptibility. Environmental disinfection is crucial in curbing healthcare-associated (HAI). Hydrogen peroxide vapor (HPV ) technology offers promise, yet its impact on and patient outcomes remains unclear. Methods: A cohort study enrolled 58 deceased adult LT recipients, comparing before after routine HPV implementation. followed terminal cleaning surgical rooms intensive care unit (ICU) boxes. Pathogen data included pre-transplant post-discharge colonization. Clinical covered recipient characteristics, disease severity, donor-recipient relationships. Statistical analyses assessed associations outcomes. Results: Twenty-seven patients were the before-HPV group, 24 after-HPV group. Demographic clinical characteristics comparable between groups. implementation significantly increased likelihood negative control swabs (odds ratio 2.33). Klebsiella pneumoniae carbapenemase was most frequent pathogen, site being primary site. Patients had shorter hospital stays (mean difference 10.54 days), notably diverging around 8th day hospitalization. HAI frequency 90-day mortality lower swabs. Conclusion: effectively reduced recipients. Negative correlated frequency, impacting positively. Despite challenges implementation, efficacy reducing suggests a valuable tool strategies for vulnerable populations like

Language: Английский

Citations

0