Evolutionary perspectives on substance and behavioural addictions: Distinct and shared pathways to understanding, prediction and prevention

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 159, P. 105603 - 105603

Published: Feb. 24, 2024

Addiction poses significant social, health, and criminal issues. Its moderate heritability early-life impact, affecting reproductive success, an evolutionary paradox: why are humans predisposed to addictive behaviours? This paper reviews biological psychological mechanisms of substance behavioural addictions, exploring explanations for the origin function relevant systems. Ancestrally, addiction-related systems promoted fitness through reward-seeking, possibly self-medication. Today, psychoactive substances disrupt these systems, leading individuals neglect essential life goals immediate satisfaction. Behavioural addictions (e.g. video games, social media) often emulate ancestrally beneficial behaviours, making them appealing yet irrelevant contemporary success. Evolutionary insights have implications how addiction is criminalised stigmatised, propose novel avenues interventions, anticipate new sources from emerging technologies such as AI. The potential glucagon-like peptide 1 (GLP-1) agonists targeting obesity suggest satiation system may be a natural counter overactivation reward system.

Language: Английский

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Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain

Pharmacological Research, Journal Year: 2018, Volume and Issue: 134, P. 212 - 219

Published: June 30, 2018

Language: Английский

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Dopamine D1 and D2 Receptors Differentially Regulate Rac1 and Cdc42 Signaling in the Nucleus Accumbens to Modulate Behavioral and Structural Plasticity After Repeated Methamphetamine Treatment

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 86(11), P. 820 - 835

Published: March 15, 2019

Language: Английский

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Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders

Frontiers in Synaptic Neuroscience, Journal Year: 2020, Volume and Issue: 12

Published: July 10, 2020

AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout brain. Changes in properties and postsynaptic abundance AMPARs pivotal mechanisms plasticity, such as long-term potentiation (LTP) depression (LTD) transmission. A wide range neurodegenerative, neurodevelopmental neuropsychiatric disorders, despite their extremely diverse etiology, pathogenesis symptoms, exhibit brain region-specific AMPAR subunit-specific aberrations or plasticity. These include abnormally enhanced reduced AMPAR-mediated Bidirectional reversal these changes by targeting subunits trafficking ameliorates drug-seeking behavior, chronic pain, epileptic seizures, cognitive deficits. This indicates bidirectional dysregulation plasticity may contribute to expression many disorders therefore serve a therapeutic target. Here, we provide synopsis animal models review preclinical evidence on AMPARs.

Language: Английский

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Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights

Physiology & Behavior, Journal Year: 2023, Volume and Issue: 268, P. 114236 - 114236

Published: May 12, 2023

Language: Английский

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