Noise - an insidious stressor affecting xenobiotic metabolism? DOI Creative Commons
R. H. Waring, Stephen Mitchell

Xenobiotica, Journal Year: 2024, Volume and Issue: 55(1), P. 1 - 3

Published: Dec. 13, 2024

Language: Английский

ANESTHESIA, PAIN MANAGEMENT, AND PUBLIC HEALTH: A REVIEW OF TECHNIQUES AND STRATEGIES FOR COINFECTED PATIENTS DOI Creative Commons

Chioma Anthonia Okolo,

Oloruntoba Babawarun,

Tolulope Olorunsogo

et al.

International Medical Science Research Journal, Journal Year: 2024, Volume and Issue: 4(3), P. 247 - 258

Published: March 17, 2024

Coinfections, particularly in patients with HIV, hepatitis C, or tuberculosis, present complex challenges anesthesia and pain management. This review examines the unique considerations, techniques, strategies for providing safe effective care to this vulnerable population. It explores impact of coinfections on outcomes, role multidisciplinary approaches, implications public health. Patients often have medical histories, including comorbidities compromised immune systems, which can affect their response Strategies such as preoperative optimization, tailored anesthetic plans, close monitoring are crucial mitigate risks ensure positive outcomes. Multidisciplinary collaboration is essential managing coinfections, involving anesthesiologists, infectious disease specialists, surgeons, other healthcare professionals. approach allows comprehensive that addresses needs coinfected patients. Public health management significant, they resource utilization, treatment overall costs. Understanding implementing lead improved outcomes In conclusion, management, requiring approaches collaboration. By addressing these challenges, providers improve contribute better overall. Keywords: Anesthesia, Pain Management, Health, Techniques, Coinfected Patients.

Language: Английский

Citations

4
CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan DOI
Sharoen Yu Ming Lim, Yan Pan, Mustafa Ahmed Alshagga

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(11), P. 1647 - 1656

Published: March 12, 2024

Abstract CYP‐14 members of the Caenorhabditis elegans ( C. ) Cytochrome P450 (CYP) enzyme family, plays important roles in mitochondrial dysfunction, detoxification, lipid metabolism, defense and lifespan regulation. The review identifies members: cyp‐14A1, cyp‐14A2, cyp‐14A3, cyp‐14A4, cyp‐14A5 their homology with human CYP families. Despite limited studies on cyp‐14 members, findings unraveled complex crosstalk between stress, detoxification mechanisms, regulation, emphasizing complexity these interconnected pathways as well how regulation depends environmental cues changes including pH, nutrients, ROS chemical stressors. underscores translational relevance to health, shedding light potential homologues implications age‐related, metabolic respiratory diseases. Among other genes, cyp‐14A2 cyp‐14A4 predominate function, heat resistance, pathways. In conclusion, insights pave way for future research, offering promising avenues therapeutic interventions targeting activity address age‐related diseases promote healthy aging.

Language: Английский

Citations

3
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro DOI
Congrong Wang,

Naixiang Zhou,

Mingcui Li

et al.

Xenobiotica, Journal Year: 2024, Volume and Issue: 54(4), P. 195 - 200

Published: Feb. 22, 2024

To assess the effect of Rehmannioside A on CYP450s activity and to estimate its inhibitory properties.The major in human liver microsomes (HLMs) was assessed with corresponding substrates marker reactions, compared a blank control respective inhibitors. Suppression CYP3A4, 2C9 2D6 by dose-dependent assay fitted non-competitive or competitive inhibition models. The CYP3A4 determined time-dependent manner.Rehmannioside suppressed 2C9, IC

Language: Английский

Citations

1
Simnotrelvir as a potential treatment for COVID-19 DOI
Matthew W. McCarthy

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(3), P. 233 - 237

Published: Feb. 11, 2024

Introduction Simnotrelvir is a selective 3-chymotrypsin-like oral protease inhibitor with activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Language: Английский

Citations

1
Increased Theophylline Plasma Concentrations in a Patient With Covid-19 DOI
M. Fernandez, Ana Concepción Sánchez Cerviño,

Ana Codonal Demetrio

et al.

Annals of Pharmacotherapy, Journal Year: 2024, Volume and Issue: unknown

Published: March 27, 2024

Language: Английский

Citations

1
Endothelium dysfunction and thrombosis in COVID-19 with type 2 diabetes DOI
Mengdi Li, Xiaoming Wu, Jialan Shi

et al.

Endocrine, Journal Year: 2023, Volume and Issue: 82(1), P. 15 - 27

Published: July 1, 2023

Language: Английский

Citations

3
Favipiravir: Emergent antiviral drug during Covid -19 DOI Creative Commons

Kondeti Venkata Surya Siva Kumar,

S. Vidyadhara,

Janga Ramesh Babu

et al.

Medical and Pharmaceutical Journal, Journal Year: 2023, Volume and Issue: 2(3), P. 175 - 180

Published: Sept. 30, 2023

Background: The SARS-CoV-2, a virus with diameter of 125 microns, has caused global pandemic, affecting millions individuals worldwide. lack specific medications against this novel coronavirus prompted the medical community to explore repurposed pharmaceuticals as potential treatment options. Among these drugs, favipiravir, initially developed for influenza, garnered significant attention, particularly in India. To better understand role favipiravir managing COVID-19, comprehensive and evidence-based evaluation is essential. This study aims provide thorough assessment favipiravir's efficacy context current COVID-19 epidemic. Method: A systematic review existing literature was conducted gather relevant evidence on use management. Various databases were searched identify clinical trials, observational studies, case reports related effectiveness treatment. Result: findings from indicate that shown promise therapeutic agent COVID-19. Several studies have reported positive outcomes, including reduced viral load, improved symptoms, shorter hospital stays, when administered patients. Conclusion: Based available evidence, appears hold medication Its antiviral activity promising outcomes make it candidate further investigation incorporation into protocols However, randomized controlled trials larger-scale are necessary establish its definitive combatting pandemic. provided may aid healthcare professionals making informed decisions regarding option

Language: Английский

Citations

2
Impact of genetic variations of gene involved in regulation of metabolism, inflammation and coagulation on pathogenesis of cardiac injuries associated with COVID-19 DOI

HariOm Singh,

Aishwarya Nair, Supriya D. Mahajan

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155608 - 155608

Published: Sept. 27, 2024

Language: Английский

Citations

0
Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis DOI Open Access
Sharoen Yu Ming Lim, Willone Lim,

Angela Paul Peter

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

The CYP33 family in Caenorhabditis elegans is integral to processes like xenobiotic detoxification, eicosanoid regulation, nanotoxicity response and spermatogenesis. Limited research on C. suggests its functions are similar human CYP33, indicating conserved roles metabolism disease. This review examines enzymes, especially CYP-33E1 CYP-33E2, their homologues, focusing biosynthesis, metabolism, Understanding these enzymes enhances insights into cytochrome P450 biology, cyp-associated diseases.

Language: Английский

Citations

0
Noise - an insidious stressor affecting xenobiotic metabolism? DOI Creative Commons
R. H. Waring, Stephen Mitchell

Xenobiotica, Journal Year: 2024, Volume and Issue: 55(1), P. 1 - 3

Published: Dec. 13, 2024

Language: Английский

Citations

0