Impact of heated tobacco products on biomarkers of potential harm and adverse events: a systematic review and meta-analysis

Tobacco Control, Journal Year: 2025, Volume and Issue: unknown, P. tc - 059000

Published: April 29, 2025

Objective To systematically review available data on the effects of heated tobacco products (HTPs) biomarkers potential harm (BoPH) and adverse events, including comparison to cigarettes, e-cigarettes smoking abstinence. Data sources Web Science, Scopus, MedRxiv, ClinicalTrials.gov, ICTRP database HTP manufacturer libraries were searched from January 2010 December 2024. Study selection Included studies interventional clinical trials any design that measured BoPH or events in adults assigned a marketed another either extraction Two reviewers independently extracted into predesigned form assessed risk bias using Cochrane’s Risk Bias tool version 1. synthesis synthesised effect direction plots. A random-effects model was used calculate pooled ratios for event data. 40 (10 independent, 29 industry-affiliated 1 unclear affiliation) included. Only nine lasted longer than 5 days. 19 involved intervention just once. high 32 8. 143 indicated short-term use had mixed compared with The rate reporting not significantly different between comparator group. Conclusions Despite growing evidence base, significant limitations hinder interpretation data, which do yet provide clear indication benefit, even cigarettes. Longer, better quality independent industry funding are needed determine health impacts HTPs.

Language: Английский

Reinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

This study investigates the reinforcing effects and monoamine oxidase-A (MAO-A) inhibitory properties of heated tobacco products (HTPs), comparing them to nicotine alone. It also examines brand-specific differences in MAO-A inhibition provide a deeper understanding role non-nicotine constituents HTP use. A rat self-administration model was used evaluate reinforcement patterns HTP-T (tobacco flavor), HTP-M (menthol under fixed-ratio schedules. In vitro assays were performed measure nicotine, HTP-T, HTP-M. Additionally, chemical composition analyses aerosols conducted compared identify potential MAO inhibitors. Finally, assessments across various brands determine whether significant exist among different products. showed comparable while demonstrated significantly higher reinforcement. revealed that both exhibited at high nicotine-equivalent concentrations (>10-2-10-1 mM), with showing stronger inhibition. contrast, Nicotine alone no Brand-specific observed, potentially driven by variations aerosol composition. HTP-M's enhanced could be attributed its menthol's synergistic on nicotine. highlight impact While this provides valuable insights into HTPs, reliance animal models highlights necessity for human studies real-world conditions.

Language: Английский