La curcumina y sus derivados como posibles candidatos antivirales contra la viruela del mono (mpox): una revisión de estudios computacionales

Ars Pharmaceutica (Internet), Journal Year: 2025, Volume and Issue: 66(2), P. 225 - 232

Published: March 19, 2025

Introduction: Monkeypox (mpox) is an infectious disease caused by the mpox virus that of global health concern because outbreak, as May 2023, has affected more than 80,000 people in hundreds countries. Currently, there no specific treatment, including antivirals, for patients. Exploration active compounds continues, one which curcumin and its derivatives. Curcumin a polyphenol compound predominantly found turmeric been documented to have antiviral effects. Therefore, this study aims explore studies investigating potential derivatives candidates targeting mpox. Method: Literature published from inception 2024 ScienceDirect, PubMed, Scopus, Google Scholar was searched. Keywords used search included curcuma, curcumin, tetrahydrocurcumin, demethoxycurcumin, bisdemethoxycurcumin, turmeric, monkeypox, Results: The literature results five computational involving derivatives, tetrahydroxycurcumin demethoxycurcumin. All showed better binding affinity with proteins compared control several antivirals. strong inhibiting replication modulating immune system. Conclusions: This review concludes However, related remain limited confined studies. Further preclinical experimental clinical are needed confirm their effectiveness mechanisms action.

Language: Английский

Role of structure-based drug design (SBDD) in the repurposing and discovery of anti-viral leads against Monkeypox virus disease

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102317 - 102317

Published: May 1, 2025

Language: Английский