Mechanistic Insights into the Biological Effects of Engineered Nanomaterials: A Focus on Gold Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4109 - 4109

Published: Feb. 18, 2023

Nanotechnology has great potential to significantly advance the biomedical field for benefit of human health. However, limited understanding nano-bio interactions leading unknowns about adverse health effects engineered nanomaterials and poor efficacy nanomedicines hindered their use commercialization. This is well evidenced considering gold nanoparticles, one most promising applications. Thus, a fundamental interest nanotoxicology nanomedicine, enabling development safe-by-design improving nanomedicines. In this review, we introduce advanced approaches currently applied in interaction studies-omics systems toxicology-to provide insights into biological at molecular level. We highlight omics toxicology studies focusing on assessment mechanisms underlying vitro responses nanoparticles. First, gold-based nanoplatforms improve healthcare along with main challenges clinical translation are presented. then discuss current limitations data support risk nanomaterials.

Language: Английский

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Tumor-derived systems as novel biomedical tools—turning the enemy into an ally

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.

Language: Английский

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Lipid-engineered nanotherapeutics for cancer management

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Cancer causes significant mortality and morbidity worldwide, but existing pharmacological treatments are greatly limited by the inherent heterogeneity of cancer as a disease, well unsatisfactory efficacy specificity therapeutic drugs. Biopharmaceutical barriers such low permeability poor water solubility, along with absence active targeting capabilities, often result in suboptimal clinical results. The difficulty successfully reaching destroying tumor cells is also compounded undesirable impacts on healthy tissue, including off-target effects high toxicity, which further impair ability to effectively manage disease optimize patient outcomes. However, last few decades, development nanotherapeutics has allowed for use rational design order maximize success. Advances fabrication nano-sized delivery systems, coupled variety surface engineering strategies promote customization, have resulted promising approaches targeted, site-specific drug fewer unwanted better efficacy. These nano systems been able overcome some challenges conventional related pharmacokinetics, biodistribution, target specificity. In particular, lipid-based nanosystems extensively explored due their biocompatibility, versatility, adaptability. Lipid-based treatment varied diverse, liposomal therapeutics, lipidic nanoemulsions, solid lipid nanoparticles, nanostructured carriers, lipid-polymer nanohybrids, supramolecular nanolipidic structures. This review aims provide an overview diverse formulations lipid-engineered current field, researchers attempt translate these from bench clinic.

Language: Английский

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Exosome-like systems: Nanotechnology to overcome challenges for targeted cancer therapies

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216151 - 216151

Published: March 29, 2023

Language: Английский

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Progress and challenges in the translation of cancer nanomedicines

Current Opinion in Biotechnology, Journal Year: 2023, Volume and Issue: 85, P. 103045 - 103045

Published: Dec. 14, 2023

Language: Английский

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