Formulation, Optimization, In-Vitro and In-Vivo Evaluation of Nateglinide-Loaded Nanostructured Lipid Carriers for Enhanced Bioavailability DOI
Shradha S. Tiwari, Yuvraj Dange, Sandip M. Honmane

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 23, 2024

Language: Английский

Marine-derived polysaccharides: the potential agents against neurodegenerative diseases DOI Creative Commons
Lin Zhu,

Yuqian Ren,

Shenghan Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Neurodegenerative diseases are primarily characterized by the selective loss of neurons in brain, leading to a significant and widespread global public health burden. Although numerous mechanisms underlying neurodegenerative have been elucidated, effective therapeutic strategies still being explored. Several drugs proposed halt disease progression; however, they often come with severe side effects. Recently, polysaccharides garnered considerable attention due their antioxidant, anti-neuroinflammatory, anticholinesterase, anti-amyloidogenic properties. The ocean contains large number animals, plants, algae fungal species. Its rich sources wide availability make research on marine become hot topic. dominated fucoidan chitosan reported inhibit progression variety ways. In this review article, we provide comprehensive summary that intervene aim exploring potential as agents.

Language: Английский

Citations

1
Entacapone Nanoemulsion: Formulation Design, Optimization, and Evaluation DOI Creative Commons

Venkateswarlu Garla,

Shahul Hussain Shaik,

Dalapathi Gugulothu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 14, 2024

Abstract Entacapone is utilized as an adjunct to levodopa therapy for the treatment of Parkinson's syndrome. According Biopharmaceutics Classification System, it classified a class IV drug. The solubility substance can be enhanced by utilizing nanoemulsion, which also effectively traverse blood-brain barrier owing its nanoscale dimensions. formulation various proportions Capmul Medium Chain Mono and Diglycerides oil phase, Pluronic F127, Phospholipin 90 hydrophilic lipophilic surfactants. Optimization was performed using 3 2 factorial designs in Design Expert ® 8.0.5.2 software, incorporating mixing speed, time, sonication parameters. nanoemulsion exhibited average particle size 120.8±1.9nm, with low polydispersity index 0.144, indicating uniform globule size. zeta potential suggested good stability, while XRD pattern indicated decreased drug crystallinity. TEM images confirm that particles falls within range 120–150 nm there no evidence aggregation. released at rate 80.33±0.92% 8 hours. current study demonstrates enhancements stability formulated nanoemulsions designed oral delivery.

Language: Английский

Citations

0
Formulation, optimization, in vitro and in vivo evaluation of Nateglinide-loaded nanostructured lipid carriers for enhanced bioavailability. DOI Creative Commons
Shradha S. Tiwari, Yuvraj Dange, Sandip M. Honmane

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract Purpose Nateglinide belongs to the meglitinide class, oral hypoglycemic drug used in treatment of insulin-resistant (Type II) diabetes mellitus. Potential constraints associated with NTG delivery include poor aqueous solubility, short action time, and quick elimination, which causes variable bioavailability. Therefore, aim present study was develop optimize NLCs formulations improve bioavailability efficient NTG. Method were prepared by a modified HPH method using box Behenken design approach. Glyceryl Monostearate Miglyol 812, Acrysol EL 135 chosen as solid lipid, liquid lipids, surfactant respectively. Obtained characterized for physicochemical properties, in-vitro release studies pharmacokinetic parameters. Result NTG-NLCs exhibited small particle size ranging from 142.8 ± 1.67 252.7 2.17 nm zeta potential 13.53 mV 30.93 mV, Polydispersibility index 0.343±0.071 0.417 ±0.058. The average encapsulation efficiency 89.99%. Optimized NTG-NLC showed nm, Potential, loading 16.04%, entrapment 93.48 %. In study, relative nateglinide-NLC increased 3.77 times than that pure nateglinide 1.54 Glinate 60 marketed formulation. half-life prolonged 1.6 times. solubility is enhanced, coupled its release. Conclusion: promising technique enhance vitro release, bioavailability, pharmacokinetics.

Language: Английский

Citations

0
Unveiling the therapeutic potential and nanotechnological approaches for the delivery of tanshinone IIA DOI Creative Commons

Diya Arora,

Vanshita Singh,

Keshav Bansal

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100494 - 100494

Published: Aug. 9, 2024

Phytochemicals, as dietary ingredients, are being extensively studied for the treatment and prevention of many illnesses. Tanshinone IIA, a plant-derived diterpene quinone has demonstrated various therapeutic effects. However, limitations like low solubility, bioavailability stability, weak targeting biodistribution, short half-life make Tan IIA an unlikely candidate effective therapy. Nanoformulations based on natural substances gaining interest approach human diseases, they provide alternative to conventional approaches, which frequently linked with number adverse effects complications. The study comprises thorough assessment existing research findings from variety sources in order collect data properties innovative delivery systems. Literature was compiled databases, including Scopus, Embase, PubMed, Google Scholar, using keywords such "Tanshinone IIA" or "diterpenes" combination "Traditional Chinese medicine", "Therapeutic potential", "Neuroprotection", "Anti-cancer", "Cardioprotection", "Nanocarriers", "Liposomes". that possesses broad array pharmacological its antidiabetic, anticancer, antioxidant, anti-inflammatory activities. nanoformulations have shown good encapsulation efficiency, sustained release, extended circulation duration, increased accumulation at diseased sites, improved efficacy, leading effectiveness plethora disorders. Nanostructured particles several benefits addressing issues limited stability phytochemicals by overcoming biological barriers. Certainly, use nano-drug carriers plant products is current trend. Furthermore, applications these must be humans. Such investigation, well evaluation dosage optimization, may pave way IIA's commercial feasibility.

Language: Английский

Citations

0
Exploring chitosan nanoparticles for enhanced therapy in neurological disorders: a comprehensive review DOI

Safa A Vahab,

Kaiprathu Anjali,

M. Sabitha

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Language: Английский

Citations

0
Nanoparticle-mediated drug delivery for neurodegenerative diseases DOI
Rabinarayan Parhi

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 267 - 307

Published: Nov. 29, 2024

Language: Английский

Citations

0
Formulation, Optimization, In-Vitro and In-Vivo Evaluation of Nateglinide-Loaded Nanostructured Lipid Carriers for Enhanced Bioavailability DOI
Shradha S. Tiwari, Yuvraj Dange, Sandip M. Honmane

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 23, 2024

Language: Английский

Citations

0