Micro,
Journal Year:
2024,
Volume and Issue:
4(4), P. 734 - 750
Published: Nov. 27, 2024
Mycoplasma
infections
pose
significant
challenges
in
the
poultry
industry,
necessitating
effective
therapeutic
interventions.
Tiamulin,
a
veterinary
antibiotic,
has
demonstrated
efficacy
against
species.
However,
emergence
of
resistant
species
could
dramatically
reduce
potential,
contributing
to
economic
losses.
Optimizing
tiamulin’s
pharmacokinetic
profile
via
nanocarrier
incorporation
enhance
its
potential
and
administration
frequency,
ultimately
reducing
strain
emergence.
Niosomes,
type
self-assembled
non-ionic
surfactant-based
nanocarrier,
have
emerged
as
promising
drug
delivery
system,
offering
improved
stability,
sustained
release,
enhanced
bioavailability.
In
this
study,
niosomal
nanocarriers
encapsulating
tiamulin
were
prepared,
characterized
assessed
Mycoplasma-inoculated
broilers
following
oral
administration.
Differential
scanning
colorimetry
(DSC)
confirmed
alterations
crystalline
state
components
integration
into
structures
formed
during
formulation
procedure.
Transmission
electron
microscopy
(TEM)
showed
spherical
nanostructure
niosomes.
The
formulated
exhibited
zeta
average
hydrodynamic
diameter
−10.65
±
1.37
mV
339.67
30.88
nm,
respectively.
Assessment
parameters
gallisepticum-infected
revealed
ability
increase
bioavailability
systemic
exposure,
marked
by
significantly
higher
area
under
curve
(AUC)
(p
<
0.01)
prolonged
elimination
half-life
(T1/2)
0.05).
Enhanced
residence
time
are
crucial
factors
maintaining
concentrations
at
reduced
doses
frequencies.
This
approach
provides
viable
strategy
decrease
risk
subtherapeutic
levels,
thereby
mitigating
development
antibiotic
resistance.
findings
presented
herein
offer
sustainable
for
efficient
use
antibiotics
medicine.
Nanotechnology Reviews,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 1, 2024
Abstract
In
this
study,
we
prepared
an
inclusion
complex
of
picoplatin
(Pc)
with
2-hydroxy
propyl
β
cyclodextrin
(HPCD)
to
improve
its
hydrophilicity,
yielding
Pc-HPCD.
The
Pc-HPCD
was
encapsulated
into
PEG-PLGA
nanoparticles
(NPs)
using
the
emulsion–solvent
evaporation
method,
Pc-HPCD@PEG-PLGA
core–shell
NPs.
assessed
1
HNMR
spectroscopy
and
a
phase
solubility
study.
addition,
average
hydrodynamic
diameter,
polydispersity
index,
zeta
potential,
encapsulation
efficiency
(EE%)
NPs
were
190.2
±
8.7
nm,
0.14
0.02,
−13.97
0.67
mV,
80.7
2.4%,
respectively.
vitro
release
study
showed
pH-triggered
manner.
Furthermore,
biological
evaluation
revealed
significantly
potent
cytotoxic
activity
(IC
50
=
1.6
0.24
µg/ml)
against
triple-negative
breast
cancer
cells
(TNBC),
surpassing
that
5.3
0.93
Pc
7.5
0.4
µg/ml).
induced
significant
apoptosis
ability
arrest
at
sub-G1
in
MDA-MB-231
cells.
Moreover,
vivo
model
established
SEC-bearing
mice,
treatment
demonstrated
inhibition
tumor
proliferation
(67.2%).
This
accompanied
by
improvements
hematological
biochemical
measurements,
as
well
histopathological
examination,
which
indicated
reduction
cellular
nuclear
pleomorphism.
Our
potential
be
employed
effective
safe
therapy
capable
conquering
TNBC.
Micro,
Journal Year:
2024,
Volume and Issue:
4(4), P. 734 - 750
Published: Nov. 27, 2024
Mycoplasma
infections
pose
significant
challenges
in
the
poultry
industry,
necessitating
effective
therapeutic
interventions.
Tiamulin,
a
veterinary
antibiotic,
has
demonstrated
efficacy
against
species.
However,
emergence
of
resistant
species
could
dramatically
reduce
potential,
contributing
to
economic
losses.
Optimizing
tiamulin’s
pharmacokinetic
profile
via
nanocarrier
incorporation
enhance
its
potential
and
administration
frequency,
ultimately
reducing
strain
emergence.
Niosomes,
type
self-assembled
non-ionic
surfactant-based
nanocarrier,
have
emerged
as
promising
drug
delivery
system,
offering
improved
stability,
sustained
release,
enhanced
bioavailability.
In
this
study,
niosomal
nanocarriers
encapsulating
tiamulin
were
prepared,
characterized
assessed
Mycoplasma-inoculated
broilers
following
oral
administration.
Differential
scanning
colorimetry
(DSC)
confirmed
alterations
crystalline
state
components
integration
into
structures
formed
during
formulation
procedure.
Transmission
electron
microscopy
(TEM)
showed
spherical
nanostructure
niosomes.
The
formulated
exhibited
zeta
average
hydrodynamic
diameter
−10.65
±
1.37
mV
339.67
30.88
nm,
respectively.
Assessment
parameters
gallisepticum-infected
revealed
ability
increase
bioavailability
systemic
exposure,
marked
by
significantly
higher
area
under
curve
(AUC)
(p
<
0.01)
prolonged
elimination
half-life
(T1/2)
0.05).
Enhanced
residence
time
are
crucial
factors
maintaining
concentrations
at
reduced
doses
frequencies.
This
approach
provides
viable
strategy
decrease
risk
subtherapeutic
levels,
thereby
mitigating
development
antibiotic
resistance.
findings
presented
herein
offer
sustainable
for
efficient
use
antibiotics
medicine.
