The Role of Freeze-Drying as a Multifunctional Process in Improving the Properties of Hydrogels for Medical Use DOI Creative Commons

Kacper Odziomek,

Anna K. Drabczyk, Paulina Kościelniak

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1512 - 1512

Published: Nov. 10, 2024

Freeze-drying is a dehydration method that extends the shelf life and stability of drugs, vaccines, biologics. Recently, its role has expanded beyond preservation to improve novel pharmaceuticals their carriers, such as hydrogels, which are widely studied for both drug delivery wound healing. The main aim this study was explore multifunctional freeze-drying in improving physicochemical properties sodium alginate/poly(vinyl alcohol)-based hydrogels medical applications.

Language: Английский

Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond DOI Creative Commons

Siddhi Throat,

Sankha Bhattacharya

Advances in Polymer Technology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Poly(N‐isopropylacrylamide) (PNIPAM) is a versatile polymer known for its phase transition properties, exhibiting lower critical solution temperature (LCST) of approximately 32°C. Below this temperature, PNIPAM hydrophilic, while above it, the becomes hydrophobic, making it ideal thermosensitive drug delivery systems (DDSs). In tissue engineering, provides biocompatible, nontoxic and stimuli‐responsive surface cell culture. Its nature ensures safety in medical applications. enhances biosensing diagnostics through affinity biomolecules, improving accuracy. Widely used hydrogels, smart textiles, soft robotics various applications, adapts to environmental changes. straightforward synthesis allows creation diverse copolymers composites, applicable selective reactions conjugations with fluorescent tags or chemical modifications. PNIPAM’s versatility extends pH‐responsive alternatives, broadening application spectrum. Practical examples include separation water treatment cleaning processes. This discussion explores biomedical particularly cancer treatment, photothermal therapy (PTT) photodynamic (PDT), gene imaging. Additionally, highlights noncancerous such as small interfering RNA (siRNA) targeting oncogenes detailed imaging deep tumour tissues.

Language: Английский

Citations

11
Freeze-drying of Bacillus amyloliquefaciens COFCAU_P1 probiotics: process optimization, and evaluation of its immunoprotective role in Labeo rohita DOI
Tanmoy Gon Choudhury,

Sangita Roy,

Suraj Kumar

et al.

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(4)

Published: March 24, 2025

Language: Английский

Citations

0
Stability Dynamics of Plant-Based Extracellular Vesicles Drug Delivery DOI Creative Commons
Saurabh Rawat, Sanchit Arora,

Madhukiran R. Dhondale

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 55 - 55

Published: April 13, 2025

Plant-based extracellular vesicles (PBEVs) have been recognized for their wide range of applications in drug delivery however, the extent medicinal applicability depends on how well they are preserved and stored. Assessing physicochemical properties, such as size, particle concentration, shape, activity cargo, forms foundation determining stability during storage. Moreover, evaluation PBEVs is essential to ensure both safety efficacy, which critical advancing clinical development. Maintaining biological EVs storage a challenging task, similar preservation cells other cell-derived products like proteins. However, despite limited studies, it expected that storing drug-loaded may present fewer challenges compared cell-based therapies, although some limitations inevitable. This article provides comprehensive overview current knowledge methods, particularly focusing role carriers. hold promise potential candidates oral administration due effective intestinal absorption ability withstand basic acidic environments. maintaining critical. this review centers isolation, characterization, PBEVs, exploring advantages offer. Furthermore, highlights key areas require further research overcome existing enhance development methods therapeutic EVs.

Language: Английский

Citations

0
Sustainable drying technologies for forage: A comprehensive review of research progress, strategies, opportunities, and future developments DOI
Jun Zhang, Cai Chen, Chenghui Yan

et al.

Sustainable Energy Technologies and Assessments, Journal Year: 2025, Volume and Issue: 77, P. 104324 - 104324

Published: April 24, 2025

Language: Английский

Citations

0
Composite porous biopolymer multilayer films as potential controlled delivery systems for tolfenamic acid DOI Open Access
A.B. Grigorov, Asya Viraneva, Maria Marudova

et al.

Journal of Physics Conference Series, Journal Year: 2025, Volume and Issue: 2952(1), P. 012017 - 012017

Published: Feb. 1, 2025

Abstract The aim of this paper is to investigate the potential composite porous biopolymer films, created by lyophilization solutions two different biopolymers (Poly-D-lactic acid/PLA and Poly-ɛ-caprolactone/PEC) at mass ratios (pure PLA, 3-to-1, 1-to-1, 1-to-3 pure PEC), for controlled release a chosen bioactive substance (tolfenamic acid). For purpose, prepared films were charged under corona discharge in standard triode system (consisting charging electrode/needle supplied with 5 kV polarity, grid 1 same polarity as grounded electrode) positive charges. A set number chitosan casein multilayers deposited on surface using layer-by-layer (LbL) deposition technique, material being loaded layers. drug kinetics total amount released dissolution medium determined use spectrometer.

Language: Английский

Citations

0
Overview of Glycometabolism of Lactic Acid Bacteria During Freeze-Drying: Changes, Influencing Factors, and Application Strategies DOI Creative Commons

Tchouli Noufeu,

Yueqin Li,

Ndeye Fatou Toure

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 743 - 743

Published: Feb. 22, 2025

Lactic acid bacteria (LAB) play a vital role in food fermentation and probiotics microeconomics. Freeze-drying (FD) is commonly used method for preserving LAB powder to extend its shelf life. However, FD induces thermal, osmotic, mechanical stresses that can impact the glycometabolism of LAB, which process converting carbohydrates into energy. This review explores effect on glycometabolism, factors influencing feasible strategies LAB. During three stages FD, freezing, primary drying or sublimation, second drying, glycolytic activity disrupted freezing stage; further, function enzymes such as hexokinase, phosphofructokinase, pyruvate kinase hindered, adenosine triphosphate (ATP) production drops significantly sublimation these enzyme activities ATP nearly cease exopolysaccharide (EPS) synthesis alters during secondary stage. Factors strain variations, pretreatment techniques, growth medium components, parameters, water influence changes. To counteract effects like cryoprotectants, encapsulation, genetic engineering help preserve their glycometabolic activity. These methods protect from harsh conditions, safeguarding flux enzymatic processes involved carbohydrate metabolism. A deeper understanding changes essential optimizing enhancing use food, medicine, biotechnology, ultimately improving performance upon rehydration.

Language: Английский

Citations

0
Mini Review on the Lyophilization: A Basic Requirement for Formulation Development and Stability Modifier DOI

Sachin Joshi,

Priya Jindal,

Shreastha Gautam

et al.

Assay and Drug Development Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Freeze-drying is popular for producing pharmaceutical formulations with structurally complicated active components and drug delivery system carriers. It the process of eliminating water from ice crystals through sublimation mechanism. Some may require drug-specific excipients such as stabilizers, buffers, bulking agents to maintain appearance assure long-term stability product. This approach utilized therapeutic compounds that are moisture sensitive, thermolabile, degrade in atmosphere. Freezing primary secondary drying critical processes lyophilization because they directly impact end result. effective a variety dosage forms, including oral, inhalation, parenteral. As result, be an important method improving efficacy various forms delivered via different routes. Additionally, used pharmacological research preserve biological samples, stabilize reference/standards, increase solubility bioavailability poorly soluble drugs. Thus, maintaining stability, efficacy, safety products throughout their development lifecycles. article includes broad overview process, principle, lyophilized medicine compositions, new technologies well applications fields.

Language: Английский

Citations

0
Review on Encapsulating Bioactive Compounds in Spices DOI

A. Hari Babu,

Rafeeya Shams,

Kshirod Kumar Dash

et al.

Food and Humanity, Journal Year: 2025, Volume and Issue: unknown, P. 100583 - 100583

Published: March 1, 2025

Language: Английский

Citations

0
Running at the verge of collapse in lyophilization: What is the impact of the edge vial effect on colloidal protein stability and particle morphology? DOI

Dominik Brandstetter,

Andrea Arsiccio,

Andrea Hawe

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 103805 - 103805

Published: April 1, 2025

Language: Английский

Citations

0
The Role of Freeze-Drying as a Multifunctional Process in Improving the Properties of Hydrogels for Medical Use DOI Creative Commons

Kacper Odziomek,

Anna K. Drabczyk, Paulina Kościelniak

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1512 - 1512

Published: Nov. 10, 2024

Freeze-drying is a dehydration method that extends the shelf life and stability of drugs, vaccines, biologics. Recently, its role has expanded beyond preservation to improve novel pharmaceuticals their carriers, such as hydrogels, which are widely studied for both drug delivery wound healing. The main aim this study was explore multifunctional freeze-drying in improving physicochemical properties sodium alginate/poly(vinyl alcohol)-based hydrogels medical applications.

Language: Английский

Citations

3