Therapeutic Applications of Nanoformulated Resveratrol and Quercetin Phytochemicals in Colorectal Cancer—An Updated Review

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 761 - 761

Published: June 4, 2024

Natural compounds such as polyphenols play several positive roles in maintaining the oxidative and inflammatory capacity of cells, which leads to their potential use anticancer therapeutics. There is promising evidence for vitro vivo activity many polyphenols, including resveratrol quercetin, specifically treatment colorectal cancer (CRC). a clear association between quercetin interfering with mechanistic pathways involved CRC, Wnt, P13K/AKT, caspase-3, MAPK, NF-κB, etc. These molecular establish role controlling cell growth, inducing apoptosis, inhibiting metastasis. The major bottleneck progression therapeutics reduced bioavailability because rapid metabolism humans. Recent advancements various nanotechnological formulations are overcoming these issues. Various nanoformulations have shown an optimistic impact on reducing solubility improving stability vivo. A combinatorial approach using could potentially increase CRC proliferation. This review discusses mechanism two bioactive polyphenolics, colon cancer, emphasis types molecules targeting cancer. It also explores synergistic effect combining nanoformulations, research delves into enhanced pharmacokinetics chemotherapeutic benefits polyphenolics when used together innovative ways.

Language: Английский

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Dermal Delivery of NanoFormulations: An Emerging Technology in Dermatological Conditions

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 3, 2025

Language: Английский

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Future Prospects and Regulatory Pathways for Invasome Technologies in Transdermal Drug Delivery

Assay and Drug Development Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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A Review on Relevance of Nanosomes in Contemporary Therapeutics: Innovative Approach to Drug Delivery

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Language: Английский

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Optimized Delivery of Enalapril Maleate via Polymeric Invasomal In-Situ Gel for Glaucoma Treatment: In vitro, In vivo, and Histological studies

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106685 - 106685

Published: Feb. 1, 2025

Language: Английский

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Advanced invasomal delivery system for enhanced topical application of bifonazole in fungal infections

Prospects in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 23(1), P. 102 - 110

Published: March 1, 2025

The design and development of invasomes containing bifonazole for effective topical fungal treatment was investigated to improve the bioavailability therapeutic efficacy this antifungal agent. Invasomes, novel lipid-based vesicular systems, were formulated enhance skin penetration provide sustained drug release, thereby increasing local concentration at site infection. formulation optimized using response surface methodology (RSM), where various factors such as phosphatidylcholine, terpenes, ethanol varied evaluate their effects on entrapment efficiency, vesicle size, release characteristics. invasomal demonstrated high efficiency (~74.12%) an average size 154.45 nm, suitable penetration. In vitro studies revealed from invasomes, with a slower profile compared plain drug. exhibited enhanced activity, suggesting that could serve promising carrier delivery bifonazole, offering potential solution treating superficial infections improved patient compliance.

Language: Английский

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Insights into Liposomal and Gel-Based Formulations for Dermatological Treatments

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 245 - 245

Published: March 26, 2025

Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.

Language: Английский

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Skin cancer: Current and new drug delivery system

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 141 - 176

Published: Jan. 1, 2025

Language: Английский

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Topical loratadine-loaded invasomal gel repurposed for vulvovaginal candidiasis; in vitro, in silico, ex vivo, and in vivo studies

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 677, P. 125639 - 125639

Published: April 24, 2025

Language: Английский

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Nano-vesicular systems for melanocytes targeting and melasma treatment: In-vitro characterization, ex-vivo skin retention, and preliminary clinical appraisal

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124731 - 124731

Published: Sept. 1, 2024

Language: Английский

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